gene

TP53

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TP53: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2479Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

TP53 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with AD, ALI, ALS. Connected to 1476 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TP53
Full Name	Tumor Protein P53
Chromosome	17p13.1
Function	p53 regulates cell cycle arrest, DNA repair, and apoptosis in response to cellular stress.
Primary Expression	all neuronal populations including: - Cortical neurons (layer 2-6) - Hippocampal neurons (CA1-CA3, dentate gyrus granule cells) - Dopaminergic neurons
Amino Acids	393 aa
Exons	11
Pathways	Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle
UniProt ID	[P04637](https://www.uniprot.org/uniprot/P04637)
Ensembl ID	ENSG00000141510
GeneCards	TP53
Human Protein Atlas	TP53
N-terminal Transactivation Domain (TAD)	Residues 1-61, interacts with transcriptional coactivators (CBP/p300, MDM2)
Proline-Rich Domain (PRR)	Residues 64-92, contains PXXP motifs for protein-protein interactions
Central DNA-Binding Domain (DBD)	Residues 102-292, recognizes p53 consensus DNA response elements
Associated Diseases	acute myeloid leukemia, AD, adverse-risk disease, age-related illness, Aging, ALI
Known Drugs/Compounds	anti-cancer drugs, CHRYSOTIXINE, Emodin, Mifepristone, PC14586, PMIγ
Interactions	ACAT1, ACHE, ACOX1, ACSL4, ACTB, ACVR2A
SciDEX Hypotheses	Epigenetic Silencing of Tumor Suppressor Genes in
KG Connections	2477 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TP53["TP53"] -->|"activates"| apoptosis["apoptosis"]
    TP53["TP53"] -->|"causes"| ESCC["ESCC"]
    TP53["TP53"] -->|"regulates"| cell_proliferation["cell proliferation"]
    TP53["TP53"] -->|"regulates"| apoptosis_1["apoptosis"]
    TP53["TP53"] -->|"regulates"| senescence["senescence"]
    TP53["TP53"] -->|"encodes"| P53["P53"]
    FGFR3["FGFR3"] -->|"interacts with"| TP53["TP53"]
    ASXL1["ASXL1"] -->|"activates"| TP53["TP53"]
    SF3B1["SF3B1"] -->|"activates"| TP53["TP53"]
    TET2["TET2"] -->|"activates"| TP53["TP53"]
    style TP53 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1545)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:TP53	data_in	dataset_row	0.00
Aging	therapeutic_target	disease	1.00
Tumor	inhibits	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
P53	inhibits	gene	1.00
Als	inhibits	disease	1.00
Tumor	associated_with	disease	1.00
Cancer	inhibits	disease	1.00
CANCER	associated_with	gene	1.00
Tumor	therapeutic_target	disease	1.00
OXIDATIVE STRESS	associated_with	gene	1.00
GENES	associated_with	gene	1.00
Tumor	activates	disease	1.00
GENES	activates	gene	1.00
CANCER	treats	gene	1.00
Cancer	treats	disease	1.00
Tumor	regulates	disease	1.00
Als	therapeutic_target	disease	1.00
DNA	activates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Carcinoma	associated_with	disease	1.00
Cancer	activates	disease	1.00
CANCER	expressed_in	gene	1.00
Als	treats	disease	1.00
P53	expressed_in	gene	1.00
Cancer	associated_with	disease	1.00
CANCER	inhibits	gene	1.00
P53	therapeutic_target	gene	1.00
GENES	therapeutic_target	gene	1.00
Apoptosis	activates	pathway	1.00
Cancer	therapeutic_target	disease	1.00
Immunotherapy	therapeutic_target	pathway	1.00
Tumor	expressed_in	disease	1.00
Als	associated_with	disease	1.00
AKT	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
Als	activates	disease	1.00
GENES	regulates	gene	1.00
DNA	implicated_in	gene	1.00
P53	regulates	gene	1.00
CANCER	activates	gene	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Cancer	expressed_in	disease	1.00
ESR1	therapeutic_target	gene	1.00
EGFR	associated_with	gene	1.00
DNA	therapeutic_target	gene	1.00
GENES	inhibits	gene	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00
DNA	associated_with	gene	1.00
BCL2	interacts_with	protein	1.00

Incoming (934)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:TP53	data_in	dataset_row	0.00
KRAS	associated_with	gene	1.00
APOPTOSIS	associated_with	gene	1.00
PI3K	associated_with	gene	1.00
TNF	therapeutic_target	gene	1.00
PI3K	therapeutic_target	gene	1.00
MTOR	associated_with	gene	1.00
AKT	associated_with	gene	1.00
ds-83b31ef18d49	data_in	dataset	1.00
AKT1	therapeutic_target	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	0.98
IRP2	post_transcriptionally_upregulates	protein	0.95
Emodin	binds_to	drug	0.95
DRAGO	interacts_with	gene	0.95
IRP2	regulates	protein	0.95
USP36	inhibits	enzyme	0.95
ASPP1	interacts_with	protein	0.95
POLY(PROLINE-ARGININE)	activates	protein	0.92
SRT2104	downregulates	drug	0.92
MDM2	inhibits	protein	0.92
Emodin	inhibits	drug	0.90
KIAA0247	interacts_with	gene	0.90
MDM2	interacts_with	gene	0.90
RBM28	suppresses	protein	0.90
FMDV VP3 protein	modulates	protein	0.90
RBM28	binds	protein	0.90
NEURON	activates	cell_type	0.90
FBL	activates	gene	0.90
PC14586	binds_to	drug	0.90
PC14586	activates	drug	0.90
ASPP1	regulates	protein	0.90
MAPK1	interacts_with	protein	0.89
CHRYSOTIXINE	activates	compound	0.88
TNF	activates	entity	0.88
ALKBH5	associated_with	entity	0.85
XPO1	reduces	protein	0.85
NFKB1	regulates	protein	0.85
Xiyangshen Sanqi Danshen Granules	downregulates	drug	0.85
ALOX12	mediates	entity	0.85
MT1	regulates	protein	0.85
KIAA0247	associated_with	gene	0.85
MT2	regulates	protein	0.85
Polygonatum Sibiricum Polysaccharide	downregulates	compound	0.85
ACTG1	binds	protein	0.85
BPA	binds_to	drug	0.85
SIRT1	downregulates	protein	0.85
PMIγ	inhibits	compound	0.85
NRF2	associated_with	gene	0.82
AUTOPHAGY	associated_with	gene	0.82

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Epigenetic Silencing of Tumor Suppressor Genes in Cancer Pro	0.438	-	-

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 1.000

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

closed · Rounds: 4 · Score: 0.75 · 2026-04-16

Senescent cell clearance as neurodegeneration therapy

closed · Rounds: 4 · Score: 0.95 · 2026-04-04

TP53

Understanding Entity Pages

Summary

Wiki Pages (4)

TP53 Gene

TIGAR - TP53-Induced Glycolysis and Apoptosis Regulator

TIGAR Protein — TP53-Induced Glycolysis and Apoptosis Regulator

TP53 Protein (p53)

Pathway Diagram

Outgoing (1545)

Incoming (934)

Targeting Hypotheses (1)

Mentioning Analyses (1)

Senescent cell clearance as neurodegeneration therapy

Experiments (0)

Related Papers (0)

Debates (2)

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

Senescent cell clearance as neurodegeneration therapy