concept

ACOX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

217Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ACOX1 is a concept in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with Cancer, Carcinoma, Hepatitis. Connected to 113 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACOX1
Key Genes/Proteins	acyl_CoA_oxidase_1, GAIN, FOXO1
Related Diseases	Axonal Loss, Ms, Tumor, Hepatitis, Carcinoma

Wiki Pages (12)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ACOX1["ACOX1"]
    ACOX1 -->|"encodes"| acyl_CoA_oxidase_1["acyl_CoA_oxidase_1"]
    ACOX1 -->|"interacts"| Tumor["Tumor"]
    ACOX1 -->|"interacts"| Hepatitis["Hepatitis"]
    ACOX1 -.biomarker for.-> Carcinoma["Carcinoma"]
    ACOX1 -->|"interacts"| FOXO1["FOXO1"]
    ACOX1 -->|"interacts"| MAP1LC3["MAP1LC3"]
    ACOX1 -->|"interacts"| TFEB["TFEB"]
    ACOX1 -->|"interacts"| MTOR["MTOR"]
    ACOX1 -->|"interacts"| AMPK["AMPK"]
    MTOR -->|"interacts"| ACOX1
    P62["P62"] -->|"interacts"| ACOX1
    PLIN3["PLIN3"] -->|"interacts"| ACOX1
    LC3["LC3"] -->|"interacts"| ACOX1
    PRKAA2["PRKAA2"] -->|"interacts"| ACOX1
    MAP3K5["MAP3K5"] -->|"interacts"| ACOX1
    TP53["TP53"] -->|"interacts"| ACOX1
    RPTOR["RPTOR"] -->|"interacts"| ACOX1
    MTORC1["MTORC1"] -->|"interacts"| ACOX1
    SIRT3["SIRT3"] -->|"interacts"| ACOX1

Outgoing (135)

Target	Relation	Type	Str
Axonal Loss	causes	phenotype	0.90
oxidative stress	modulates	process	0.80
metabolic homeostasis	contributes_to	process	0.75
acyl_CoA_oxidase_1	encodes	protein	0.72
Ms	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
GAIN	associated_with	gene	0.60
FOXO1	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
Mtor	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60

Incoming (82)

Source	Relation	Type	Str
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
AND	causes	gene	0.60
P53	interacts_with	gene	0.60
RUBCNL	interacts_with	gene	0.60
rapamycin	targets	drug	0.60
ABCB1	activates	gene	0.60
GAIN	causes	gene	0.50
PHAGOCYTOSIS	activates	gene	0.50
TFEB	activates	protein	0.50
Autophagy	activates	process	0.50
STING1	activates	protein	0.50
ULK1	activates	gene	0.50
KDM6B	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ACOX1

Understanding Entity Pages

Summary

Wiki Pages (12)

Peroxisome Pathway in Neurodegeneration

Peroxisomal Dysfunction

Peroxisome Dysfunction in Neurodegeneration

Peroxisome Pathway in Neurodegeneration

Peroxisomal Dysfunction Hypothesis in Parkinson's Disease

Ferroptosis and Lipid Peroxidation in 4R-Tauopathies

Peroxisome Signaling Pathway in Neurodegeneration

peroxisome-dysfunction-4r-tauopathies

PPAR Signaling Pathway in Neurodegeneration

ABCD2 — ATP Binding Cassette Subfamily D Member 2