concept

C1Q/C3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1Q/C3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

161Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

C1Q/C3 is a concept in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with Aging, Anxiety, Depression. Connected to 56 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	C1Q/C3
Related Diseases	neurodegeneration, Neurodegeneration, Aging, Anxiety, Depression
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    C1Q_C3["C1Q/C3"]
    C1Q_C3 -->|"causes"| Anxiety["Anxiety"]
    C1Q_C3 -->|"causes"| Aging["Aging"]
    C1Q_C3 -->|"regulates"| Depression["Depression"]
    C1Q_C3 -->|"inhibits"| RAB11["RAB11"]
    C1Q_C3 -->|"inhibits"| COMPLEMENT["COMPLEMENT"]
    C1Q_C3 -->|"inhibits"| C1Q["C1Q"]
    C1Q_C3 -->|"inhibits"| Complement["Complement"]
    C1Q_C3 -->|"inhibits"| Phagocytosis["Phagocytosis"]
    C1Q_C3 -->|"inhibits"| RAB5["RAB5"]
    RAB5 -->|"inhibits"| C1Q_C3
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"inhibits"| C1Q_C3
    COMPLEMENT -->|"regulates"| C1Q_C3
    C1Q -->|"inhibits"| C1Q_C3
    ANXIETY["ANXIETY"] -->|"causes"| C1Q_C3
    MICROGLIA["MICROGLIA"] -->|"inhibits"| C1Q_C3
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"causes"| C1Q_C3
    DEPRESSION["DEPRESSION"] -->|"regulates"| C1Q_C3
    AND["AND"] -->|"inhibits"| C1Q_C3

Outgoing (96)

Target	Relation	Type	Str
neurodegeneration	promoted: SASP-Mediated Complement Cascade Amplification	disease	0.67
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Anxiety	causes	disease	0.65
Aging	causes	disease	0.65
Depression	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ftd	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
DEPRESSION	mediates	entity	0.60
PHAGOCYTOSIS	mediates	entity	0.60
DEPRESSION	activates	entity	0.60
PHAGOCYTOSIS	activates	entity	0.60
PHAGOCYTOSIS	inhibits	entity	0.60
PHAGOCYTOSIS	downregulates	entity	0.60
BDNF	associated_with	gene	0.60
RAB11	inhibits	gene	0.60
PI3K	associated_with	gene	0.60
STX17	associated_with	gene	0.60
AKT	associated_with	gene	0.60
IGF2BP1	associated_with	gene	0.60
ELAVL2	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LONP1	associated_with	gene	0.60
C1Q	inhibits	gene	0.60
CLPP	associated_with	gene	0.60
FUS	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RAB5	inhibits	gene	0.60
C1Q	therapeutic_target	gene	0.60
C1Q	activates	gene	0.60
PI3K	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
COMPLEMENT	inhibits	gene	0.60
AGING	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Tdp-43	associated_with	pathway	0.60
Protein Aggregation	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60

Incoming (65)

Source	Relation	Type	Str
C1Q	mediates	entity	0.60
C1Q	activates	entity	0.60
C1Q	downregulates	entity	0.60
C1Q	therapeutic_target	entity	0.60
MTOR	associated_with	gene	0.60
FUS	associated_with	gene	0.60
RAB5	inhibits	gene	0.60
C1Q	inhibits	gene	0.60
IGF2BP1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
AKT	associated_with	gene	0.60
FUS	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
RAB11	inhibits	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
SNAP29	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
TDP-43	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
PHAGOCYTOSIS	inhibits	gene	0.60
COMPLEMENT	regulates	gene	0.60
ANXIETY	causes	gene	0.60
MICROGLIA	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
DEPRESSION	regulates	gene	0.60
AGING	associated_with	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
ANXIETY	therapeutic_target	gene	0.60
COMPLEMENT	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
METTL3	therapeutic_target	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60
COMPLEMENT	inhibits	gene	0.60
WNT	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
PHAGOCYTOSIS	therapeutic_target	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
WNT	associated_with	gene	0.60
MAPK	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Mediated Complement Cascade Amplification	0.703	neurodegeneration	Senolytic therapy for age-related neurod

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887]	Chen TY, Wu N, Sun X	Life (Basel)	2026	1
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548]	Hong S, Beja-Glasser VF, Nfonoyim BM, Fr	Science	2016	1
Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors i [PMID:41914021]	Xie M, Feng L, Li R, Li M, Shen L, Zhang	CNS neuroscience & therapeutic	2026	0
Vaccine-induced antibodies can limit Salmonella infection in the absence of comp [PMID:41738756]	Perez-Toledo M, Aksu-Istil K, Marcial-Ju	mBio	2026	0
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436]	Gopalakrishna PK, Che Mohd Nassir CMN, A	Cellular and molecular neurobi	2026	0
Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-C [PMID:41766448]	Taxiarchis A, Pruner I	Current opinion in hematology	2026	0
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026	0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025	0
PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of [PMID:39947489]	Zhao Q, Zeng C, Luo F, Xian Z, Wen H, Tu	Brain, behavior, and immunity	2025	0
Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflamma [PMID:38342616]	Ambrin G, Kang YJ, Van Do K, Lee C, Sing	Advanced science (Weinheim, Ba	2024	0
Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric [PMID:38456789]	["Zhu J", "Wei R", "Hu G", "Wang H", "Wa	Small (Weinheim an der Bergstr	2024	0
The Role of Complement Dysregulation in Glaucoma. [PMID:38396986]	["Hoppe C", "Gregory-Ksander M"]	International journal of molec	2024	0
Retracted: Ginsenoside Rg1 Ameliorates Acute Renal Ischemia/Reperfusion Injury v [PMID:38234567]	["Longevity O"]	Oxidative medicine and cellula	2024	0
Divergent complement system activation in two clinically distinct murine models [PMID:35958570]	["Linzey M", "DiSano K", "Welsh N", "Pac	Frontiers in immunology	2022	0
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheim [PMID:35236834]	Zhao Y, Hu D, Wang R, Sun X, Ropelewski	Nature communications	2022	0
Impact of satellite blood culture on early diagnosis of sepsis. [PMID:36789234]	["Guo Z", "Guo B", "Wang S", "Zhang H",	Journal of intensive medicine	2022	0

C1Q/C3

Understanding Entity Pages

Summary

Wiki Pages (20)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

neuroinflammation

Microglial Cells — Cell Type Hierarchy

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Neuroinflammation Across AD, PD, ALS, FTD, and HD

AD Biomarker-to-Mechanism Mapping

Amyloid-beta Cellular Uptake Pathway

AMPA Receptor Neurons

TREM2 in Frontotemporal Dementia

Neuroinflammation Microglia

microglial-synaptic-pruning-dysregulation

Mechanisms Dashboard

Complement-Mediated Synapse Loss

Microglia Activation Mechanism

Arsenic Exposure and Alzheimer's Disease Mechanism

FTD-ALS Spectrum

Neuroinflammation in Alzheimer's Disease

Neuroinflammation Pathway