concept

SS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

162Connections

30Hypotheses

30Analyses

1Outgoing

50Incoming

Summary

SS is a concept in neurodegeneration research. Key relationships include: implicated in, contributes to, causes. Connected to 162 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SS
Key Genes/Proteins	MAP1B, MAP2, MAP6, GLUT4, PPAR, RAB7A
Related Pathways	IFN_PATHWAY, PI3K_AKT_MTOR
Linked Hypotheses	95 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SS["SS"]
    SS -->|"causes"| SALIVARY_GLAND["SALIVARY_GLAND"]
    T_CELL["T_CELL"] -->|"contributes to"| SS
    B_CELL["B_CELL"] -->|"contributes to"| SS
    IFN_PATHWAY["IFN_PATHWAY"] -->|"contributes to"| SS
    PI3K_AKT_MTOR["PI3K_AKT_MTOR"] -->|"contributes to"| SS
    MAP1B["MAP1B"] -->|"implicated in"| SS
    MAP2["MAP2"] -->|"implicated in"| SS
    MAP6["MAP6"] -->|"implicated in"| SS
    GLUT4["GLUT4"] -->|"implicated in"| SS
    PPAR["PPAR"] -->|"implicated in"| SS
    RAB7A["RAB7A"] -->|"implicated in"| SS

Outgoing (1)

Target	Relation	Type	Str
SALIVARY_GLAND	causes	cell_type	0.72

Incoming (161)

Source	Relation	Type	Str
T_CELL	contributes_to	cell_type	0.64
B_CELL	contributes_to	cell_type	0.64
IFN_PATHWAY	contributes_to	pathway	0.64
PI3K_AKT_MTOR	contributes_to	pathway	0.64
MAP1B	implicated_in	gene	0.50
MAP2	implicated_in	gene	0.50
MAP6	implicated_in	gene	0.50
GLUT4	implicated_in	gene	0.50
PPAR	implicated_in	gene	0.50
RAB7A	implicated_in	gene	0.50
LRP2	implicated_in	gene	0.50
ACTB	implicated_in	gene	0.50
CTSD	implicated_in	gene	0.50
ATG	implicated_in	gene	0.50
EGFR	implicated_in	gene	0.50
SREBF1	implicated_in	gene	0.50
NADH	implicated_in	gene	0.50
MTORC1	implicated_in	gene	0.50
PPARG	implicated_in	gene	0.50
RPS6KB1	implicated_in	gene	0.50
PPARA	implicated_in	gene	0.50
LAMP1	implicated_in	gene	0.50
RUBCN	implicated_in	gene	0.50
MTOR	implicated_in	gene	0.50
RAS	implicated_in	gene	0.50
RPS6	implicated_in	gene	0.50
PIK3C3	implicated_in	gene	0.50
ATP	implicated_in	gene	0.50
SQSTM1	implicated_in	gene	0.50
CAT	implicated_in	gene	0.50
ROS	implicated_in	gene	0.50
BACE1	implicated_in	gene	0.50
LIS1	implicated_in	gene	0.50
DCX	implicated_in	gene	0.50
CD2AP	implicated_in	gene	0.50
RELN	implicated_in	gene	0.50
APOE	implicated_in	gene	0.50
HCN1	implicated_in	gene	0.50
HCN4	implicated_in	gene	0.50
HCN2	implicated_in	gene	0.50
SLC16A2	implicated_in	gene	0.50
SLC16A1	implicated_in	gene	0.50
GSS	implicated_in	gene	0.50
CYP2E1	implicated_in	gene	0.50
IDH2	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50
VEGFA	implicated_in	gene	0.50
EEF1A1	implicated_in	gene	0.50
APOB	implicated_in	gene	0.50
MET	implicated_in	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.662	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen	0.639	neurodegeneration	Gene expression changes in aging mouse b
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
CYP46A1 Overexpression Gene Therapy	0.631	neurodegeneration	Lipid raft composition changes in synapt
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Alpha-gamma cross-frequency coupling enhancement to restore	0.621	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.612	neurodegeneration	Gene expression changes in aging mouse b
TREM2-ASM Crosstalk in Microglial Lysosomal Senescence	0.612	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener	0.607	neurodegeneration	Gene expression changes in aging mouse b
Multi-Modal Stress Response Harmonization	0.601	neurodegeneration	Digital biomarkers and AI-driven early d
Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Ove	0.592	neurodegeneration	Epigenetic reprogramming in aging neuron
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.589	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.585	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.580	neurodegeneration	Gene expression changes in aging mouse b
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass	0.576	neurodevelopment	How does SYNGAP1, a 'synaptic' protein,
ER Stress Reduction as Adjunctive Therapy to Support Autopha	0.566	neurodegeneration	Why does iron chelation therapy worsen o
Complement C1q Suppression as Mechanism Linking Exercise Pla	0.560	neurodegeneration	What are the specific circulating factor
Chromatin Accessibility Restoration via BRD4 Modulation	0.559	neurodegeneration	Epigenetic reprogramming in aging neuron
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biase	0.525	neurodegeneration	Do SCFAs directly modulate α-synuclein a
Heterogeneous astrocyte activation states differentially imp	0.523	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.520	neurodegeneration	How do the seven novel ALS genes functio
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In	0.515	neurodegeneration	Perivascular spaces and glymphatic clear
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.515	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (30)

Scientific analyses that reference this entity

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.780

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.576

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

drug delivery | 2026-04-15 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548]	Hong S, Beja-Glasser VF, Nfonoyim BM, Fr	Science	2016	1
Potential Biological Processes Related to Brain SLC13A5 Across the Lifespan: Wei [PMID:41750164]	Ferreira BK, Schuck PF, Ferreira GC, Fre	Brain sciences	2026	0
How cytochrome P450 enzymes in humans are involved in Parkinson's disease: a lit [PMID:41730497]	Ren B, Yan H, Han C, Sun S, Wang D, Xu Y	Neuroscience	2026	0
Dysregulated Cholesterol Clearance via CYP46A1 Contributes to Cerebellar Sterol [PMID:41828569]	Tapia PJ, Rivera BI, Espinoza CS, Stolze	International journal of molec	2026	0
Efavirenz treatment improves retinal vaso-obliteration and pathological neovascu [PMID:41810243]	Bailey B, Rudd Zhong Manis J, Seth G, Ra	Frontiers in medicine	2026	0
Radiosynthesis and Evaluation of 18F‑Labeled Deuterated Radioligand for Positron [PMID:41704371]	Li Y, Song Z, Shi H, Zhao T, Chen J, Zho	ACS medicinal chemistry letter	2026	0
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445]	Qin J, Ma S, Wang J, Huang S, Luan J, He	Cell death & disease	2026	0
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795]	Gao C, Liu B, Zhang R, Tian J, Xin H	Toxicology mechanisms and meth	2026	0
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890]	Rao W, Huang Y, Li J, Chen Q, Sun J et a	J Stroke Cerebrovasc Dis	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496]	Che L, Zhu L, Zhou L, Zhou Y	Biochim Biophys Acta Rev Cance	2026	0
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570]	Chien Y, Xia R, Zhou D, Ai Y, Wu L et al	Hepatol Commun	2026	0
[The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579]	Wu K, Wang N, Zhao D, Wei W, Zhang W et	Zhejiang Da Xue Xue Bao Yi Xue	2026	0
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558]	Singh P, Rath SL	Journal of Alzheimer's disease	2026	0
Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334]	Song C, Wu X, Chen C, Shen B, He Y, Liu	Drug design, development and t	2026	0
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914]	["Xin R", "Zhang J", "Zhang Y", "Dai M",	Free radical biology & medicin	2026	0
Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086]	Wang Y, Zhang W, Zhang M, Zhu Y, Wang W,	Tissue & cell	2026	0
Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362]	Xu J, Sun M, Wang C, Ju P, Guan XD, Xie	International journal of ophth	2026	0

SS

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

primary-progressive-aphasia

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

NTF4 Protein

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

Mitochondrial Dysfunction in Parkinson's Disease

oxidative-stress-comparison

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Blood-Brain Barrier Biology and Crossing Strategies

deferiprone-neurodegeneration

Infectious Triggers in Alzheimer's Disease

Mitochondrial Dysfunction in Neurodegeneration

Stargardt Disease

Excitotoxicity in Neurodegeneration

vitamin-d-therapy-neurodegeneration

Synucleinopathies

Gene-Mechanism-Therapy Causal Chains

ATP5F1 — ATP Synthase F1 Subunit Beta

Pathway Diagram

Outgoing (1)

Incoming (161)

Targeting Hypotheses (30)

Mentioning Analyses (30)

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

What are the specific molecular determinants that govern tau strain selection du

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

Are age-related static epigenetic patterns pathogenic or protective compensatory

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What is the temporal sequence of TREM2 signaling transition from protective to i

Are interneuron oscillation deficits compensatory responses or primary pathologi

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

What are the precise temporal dynamics of astrocyte ketone production decline du

How does engineered C. butyricum cross the blood-brain barrier to directly bind

What are the physiological functions of BACE1 beyond APP processing that could c

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

How does pericyte senescence mechanistically promote glioma cell growth and inva

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

How does APOE4's beneficial immune function reconcile with its established role

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

Related Papers (20)