gene

C1S

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1S: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

128Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

0Experiments

0Debates

Summary

C1S (Complement Component 1, S Subcomponent): serine protease component of the classical complement pathway, involved in neuroinflammation, synaptic pruning, and implicated in Alzheimer's disease, Parkinson's disease, and age-related macular degeneration.

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🧬 Gene Info

Gene Symbol	C1S
Full Name	Complement Component 1, S Subcomponent
Chromosome	12p13.31
Protein Family	MASP family (Mannan-binding lectin-associated serine proteases)
Protein Type	Protease
Function	encodes a serine protease that is an essential component of the C1 complex in the classical complement pathway.
Molecular Weight	9 kDa
Amino Acids	688 aa
Pathways	Complement
UniProt ID	P09872
NCBI Gene ID	716
Ensembl ID	ENSG00000159189
OMIM	120580
GeneCards	C1S
Human Protein Atlas	C1S
Associated Diseases	Aging, Als, Alzheimer, Autoimmune, Carcinoma, Cirrhosis
Interactions	AND, C1R, CD47, CFH, CLN5, COMPLEMENT
KG Connections	126 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: C1S — AlphaFold P09872 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

C1S Gene

gene · 1865 words

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Pathway Diagram

graph TD
    C1S["<b>C1S</b>"]
    C1s["C1s"]
    C1S -->|"encodes"| C1s
    Neurodegeneration{"Neurodegeneration"}
    C1S -->|"associated with"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    C1S -->|"associated with"| Alzheimer
    Hepatitis{"Hepatitis"}
    C1S -->|"associated with"| Hepatitis
    Als{"Als"}
    C1S -->|"associated with"| Als
    Cirrhosis{"Cirrhosis"}
    C1S -->|"associated with"| Cirrhosis
    Carcinoma{"Carcinoma"}
    C1S -->|"associated with"| Carcinoma
    Autoimmune{"Autoimmune"}
    C1S -->|"associated with"| Autoimmune
    CLUSTERIN["CLUSTERIN"]
    C1S -->|"regulates"| CLUSTERIN
    C1Q["C1Q"]
    C1S -->|"regulates"| C1Q
    CR1["CR1"]
    C1S -->|"associated with"| CR1
    CFH["CFH"]
    C1S -->|"associated with"| CFH
    CLU["CLU"]
    CLU -->|"regulates"| C1S
    C1Q -->|"regulates"| C1S
    RS6656401["RS6656401"]
    RS6656401 -->|"associated with"| C1S
    RS3919533["RS3919533"]
    RS3919533 -->|"associated with"| C1S
    CLUSTERIN -->|"regulates"| C1S
    CFH -->|"associated with"| C1S
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"therapeutic target"| C1S
    C1QC["C1QC"]
    C1QC -->|"therapeutic target"| C1S
    style C1S fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (82)

Target	Relation	Type	Str
C1s	encodes	protein	0.70
Aging	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Als	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Als	inhibits	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Cirrhosis	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
ALS	regulates	disease	0.65
complement cascade	participates_in	pathway	0.60
SYNAPTIC PRUNING	associated_with	gene	0.60
AND	regulates	gene	0.60
COMPLEMENT GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
C3	regulates	gene	0.60
oligodendrocytes	expressed_in	cell_type	0.60
Alzheimer's disease	interacts_with	disease	0.60
Parkinson's disease	interacts_with	disease	0.60
ALS	interacts_with	disease	0.60
multiple sclerosis	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
blood-brain barrier	participates_in	pathway	0.60
C1R	regulates	gene	0.60
Complement	interacts_with	pathway	0.60
Innate Immunity	activates	pathway	0.60
CR1	interacts_with	gene	0.60
CLN5	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
SIGLEC9	interacts_with	gene	0.60
SIRPA	interacts_with	gene	0.60
TPP1	interacts_with	gene	0.60
VEGFB	interacts_with	gene	0.60
Complement	regulates	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
CFH	interacts_with	gene	0.60
CLU	associated_with	gene	0.60
C1Q	therapeutic_target	gene	0.60
C1QA	regulates	gene	0.60
CD47	regulates	gene	0.60
C3	biomarker_for	gene	0.60
CHI3L1	biomarker_for	gene	0.60
CSF1R	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
ITGAM	biomarker_for	gene	0.60
MAP2	biomarker_for	gene	0.60

Incoming (46)

Source	Relation	Type	Str
rs3919533	regulates	gene	0.70
C1S	encodes	gene	0.70
CLU	regulates	gene	0.60
RS6656401	associated_with	gene	0.60
RS3919533	associated_with	gene	0.60
AGING	associated_with	gene	0.60
GENES	regulates	gene	0.60
C1R	interacts_with	gene	0.60
RS6656401	implicated_in	gene	0.60
RS3919533	implicated_in	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
RS6664877	implicated_in	gene	0.60
AMYLOID	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
RS6664877	associated_with	gene	0.60
AND	associated_with	gene	0.60
AND	interacts_with	gene	0.60
C1QB	regulates	gene	0.60
C1R	regulates	gene	0.60
SIRPA	regulates	gene	0.60
C1QC	regulates	gene	0.60
C1QA	regulates	gene	0.60
ITGAM	regulates	gene	0.60
MERTK	regulates	gene	0.60
C1QC	therapeutic_target	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
C1Q	regulates	gene	0.60
CLUSTERIN	regulates	gene	0.60
CFH	associated_with	gene	0.60
CR1	associated_with	gene	0.60
CD47	regulates	gene	0.60
AIF1	biomarker_for	gene	0.60
C1QA	biomarker_for	gene	0.60
C1QB	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
C1R	biomarker_for	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
C1R	expressed_in	gene	0.55
ALZHEIMER	regulates	gene	0.50
C1QA	co_discussed	gene	0.50
C1QB	co_discussed	gene	0.50
C1QC	co_discussed	protein	0.50
C1R	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity