concept

PROTEINS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROTEINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1214Connections

11Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

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💡 Concept Info

Name	PROTEINS
Related Diseases	APOPTOSIS, LATE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Proteins

index · 465 words

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Pathway Diagram

graph TD
    PROTEINS["PROTEINS"]
    style PROTEINS fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PROTEINS -->|"involved_in"| Age_Related_Disease_Risk(Age-Related Disease Risk)
    PROTEINS -->|"regulates"| APOPTOSIS(APOPTOSIS)
    PROTEINS -->|"references"| SIRT6([SIRT6])
    PROTEINS -->|"references"| MMP2([MMP2])
    PROTEINS -->|"references"| PYCARD([PYCARD])
    PROTEINS -->|"references"| HNRNPA2B1([HNRNPA2B1])
    PROTEINS -->|"references"| AQP4([AQP4])
    PROTEINS -->|"references"| COX4I1([COX4I1])
    PROTEINS -->|"references"| HSPA1A([HSPA1A])
    PROTEINS -->|"references"| CREB1([CREB1])
    ROS(ROS) -->|"causes"| PROTEINS

Outgoing (113)

Target	Relation	Type	Str
Age-Related Disease Risk	involved_in	phenotype	0.90
Mortality Risk	risk_factor_for	phenotype	0.85
Disease Risk	risk_factor_for	phenotype	0.85
Prostate Cancer Biomarkers	associated_with	biomarker	0.80
APOPTOSIS	regulates	phenotype	0.64
AUTOPHAGOSOME	inhibits	concept	0.50
STRESS GRANULES	activates	concept	0.50
AMYLOID-β	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
CELL PROLIFERATION	associated_with	concept	0.50
CEREBROSPINAL FLUID	expressed_in	concept	0.50
LEWY BODY	activates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
NUCLEUS	regulates	concept	0.50
CEREBROSPINAL FLUID	activates	concept	0.50
METFORMIN	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	regulates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
NUCLEUS	associated_with	concept	0.50
MTOR SIGNALING	activates	concept	0.50
TEMPORAL LOBE	regulates	concept	0.50
IL-17	interacts_with	concept	0.50
FRONTAL	associated_with	concept	0.50
TEMPORAL LOBE	associated_with	concept	0.50
EXTRACELLULAR VESICLES	expressed_in	concept	0.50
CHOLESTEROL METABOLISM	interacts_with	concept	0.50
FURIN	associated_with	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
SELECTIVE AUTOPHAGY	associated_with	concept	0.50
GSK3	activates	concept	0.50
PI3K/AKT SIGNALING	activates	concept	0.50
STRESS GRANULES	associated_with	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	interacts_with	concept	0.50
AUTOPHAGOSOME	associated_with	concept	0.50
RAPAMYCIN	activates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	activates	concept	0.50
AUTOPHAGOSOME	regulates	concept	0.50
AUTOPHAGOSOME	interacts_with	concept	0.50
B CELLS	interacts_with	concept	0.50
FIBROBLASTS	activates	concept	0.50
ENDOPLASMIC RETICULUM	regulates	concept	0.50
GENE EXPRESSION	activates	concept	0.50
ISCHEMIC STROKE	expressed_in	concept	0.50
GENE EXPRESSION	inhibits	concept	0.50
Neuroprotection	activates	process	0.50
α-SYNUCLEIN	activates	concept	0.50
LEWY BODY	inhibits	concept	0.50
AMYGDALA	associated_with	concept	0.50
AMYGDALA	activates	concept	0.50

Incoming (1101)

Source	Relation	Type	Str
ROS	causes	phenotype	0.64
apoptosis	regulates	process	0.50
ULK1	interacts_with	gene	0.50
SYNCRIP	activates	concept	0.50
CDC42	associated_with	gene	0.50
SYNCRIP	associated_with	concept	0.50
Neuron	interacts_with	cell_type	0.50
Pi3K	activates	pathway	0.50
PKM2	activates	protein	0.50
GLYCOLYSIS	activates	pathway	0.50
MAP2	interacts_with	gene	0.50
MAP1B	interacts_with	gene	0.50
MAP6	interacts_with	gene	0.50
MAP6	regulates	gene	0.50
Neurogenesis	interacts_with	pathway	0.50
MICROTUBULES	interacts_with	concept	0.50
Neuron	associated_with	cell_type	0.50
NEURONS	associated_with	concept	0.50
GLUT4	activates	concept	0.50
INSULIN	activates	concept	0.50
NUDEL	interacts_with	protein	0.50
DYNEIN	interacts_with	protein	0.50
LIS1	interacts_with	protein	0.50
FOXO3	activates	gene	0.50
MITOCHONDRIAL DNA	activates	gene	0.50
MTDNA	activates	gene	0.50
STROKE	expressed_in	gene	0.50
ISCHEMIC	expressed_in	concept	0.50
OCCLUDIN	activates	protein	0.50
COPD	activates	disease	0.50
MCOLN1	inhibits	gene	0.50
VPS34	interacts_with	protein	0.50
ENDOSOMES	activates	concept	0.50
PIEZO1	associated_with	gene	0.50
PIEZO2	associated_with	gene	0.50
NRF2	associated_with	gene	0.50
TFAM	activates	gene	0.50
PGC-1Α	activates	protein	0.50
NRF2	regulates	gene	0.50
UBIQUITIN	associated_with	protein	0.50
UBIQUITIN	expressed_in	protein	0.50
CELL SURVIVAL	expressed_in	concept	0.50
mitophagy	regulates	pathway	0.50
SOX2	regulates	gene	0.50
KLF4	regulates	gene	0.50
MIRNAS	regulates	gene	0.50
OCT4	regulates	concept	0.50
Neuroinflammation	activates	process	0.50
oxidative stress	activates	phenotype	0.50
MCOLN1	activates	gene	0.50

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ASO-mediated reduction of toxic C9orf72 dipeptide repeat pro	0.760	neurodegeneration	Test
C9orf72 Hexanucleotide Repeat Dipeptide Repeat Proteins Inhi	0.738	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
ATXN2 Antisense Oligonucleotides Reduce Dipeptide Repeat Pro	0.630	neurodegeneration	Test
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m	0.621	neurodegeneration	Mitochondrial transfer between astrocyte
RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-m	0.497	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp

Sulfated glycans and metal-binding CSF proteins brace alpha-	0.489	neurodegeneration	Which specific CSF molecular components
CHIP E3 Ligase Enhancement to Target Synaptic Proteins for D	0.474	proteomics	Quantitative proteomics of the aging syn
Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rat	0.122	molecular-biology	Does Alectinib truly bind C1q directly w
Multivalent Decoy Proteins for Condensate Redirection	0.000	-	What determines the specificity of DDR p
Proximity-Induced Degradation of Mislocalized Proteins	0.000	-	How do protein-protein interactions dete
mTOR Inhibition Promotes Astrocytic Clearance of Inflammator	0.000	-	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
AAV-LRRK2 IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Gap Junction Dysfunction Validation in Parkinson's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
AAV-LRRK2 Gene Therapy IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson'	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neuro	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745]	Rydzanicz M, Jagła M, Kosinska J, Tomasi	Clin Genet	2017	1
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375]	van Spronsen M, Mikhaylova M, Lipka J, S	Neuron	2013	1
Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670]	Randall TS, Moores C, Stephenson FA	FEBS Lett	2013	1
Therapeutic developments in pancreatic cancer. [PMID:37798442]	["Hu Z", "O'Reilly E"]	Nature reviews. Gastroenterolo	2024	0
Defining treatment-resistant depression. [PMID:31638723]	["Gaynes B", "Lux L", "Gartlehner G", "A	Depression and anxiety	2020	0
Emerging trends in global freshwater availability. [PMID:29769728]	["Rodell M", "Famiglietti J", "Wiese D",	Nature	2018	0
Acute Heart Failure: Definition, Classification and Epidemiology. [PMID:28785969]	["Kurmani S", "Squire I"]	Current heart failure reports	2017	0
Invasive ductal carcinoma: relationship between pathological characteristics and [PMID:28658335]	["Aquino R", "Vasques P", "Cavalcante D"	Revista do Colegio Brasileiro	2017	0
The Impact of Intergenerational Cultural Dissonance on Alcohol Use Among Vietnam [PMID:26598062]	["Kane J", "Johnson R", "Robinson C", "J	The Journal of adolescent heal	2016	0
A proliferative burst during preadolescence establishes the final cardiomyocyte [PMID:24813607]	["Naqvi N", "Li M", "Calvert J", "Tejada	Cell	2014	0
Family medicine match rate increases slightly. [PMID:22585896]	Sheri Porter	Annals of family medicine	2012	0
Human plasma glycome in attention-deficit hyperactivity disorder and autism spec [PMID:20974899]	["Pivac N", "Knezevi\u0107 A", "Gornik O	Molecular & cellular proteomic	2011	0
The Crumbs complex: from epithelial-cell polarity to retinal degeneration. [PMID:19625503]	["Bulgakova N", "Knust E"]	Journal of cell science	2009	0
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell [PMID:18971423]	["Landsman L", "Bar-On L", "Zernecke A",	Blood	2009	0
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins [PMID:15644324]	Brickley K, Smith MJ, Beck M, Stephenson	The Journal of biological chem	2005	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PROTEINS in their description or question text

Sulfated glycans and metal-binding CSF proteins brace alpha-synuclein fibril pol

Score: 0.489 · neurodegeneration · 2026-04-25

Electrostatic bridging by glycans and low-abundance proteins preserves disease-relevant fibril architecture.

CHIP E3 Ligase Enhancement to Target Synaptic Proteins for Degradation

Score: 0.474 · proteomics · 2026-04-25

CHIP E3 Ligase Enhancement to Target Synaptic Proteins for Degradation

Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rather Than Circulating

Score: 0.122 · molecular-biology · 2026-04-18

## Mechanistic Overview Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rather Than Circulating C1q starts from

Multivalent Decoy Proteins for Condensate Redirection

Score: 0.000 · unknown disease · 2026-04-28

Engineered decoy proteins with multiple condensate-targeting domains could sequester pathological proteins away from har

Proximity-Induced Degradation of Mislocalized Proteins

Score: 0.000 · unknown disease · 2026-04-28

Location-specific PROTAC-like molecules that selectively degrade proteins appearing in incorrect subcellular compartment

mTOR Inhibition Promotes Astrocytic Clearance of Inflammatory Proteins

Score: 0.000 · unknown disease · 2026-04-28

Enhancing autophagy specifically in reactive astrocytes through targeted mTOR inhibition could accelerate clearance of a