concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1568Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	ACTIN
Key Genes/Proteins	4E-BP1, ABCA1, ABCD3, ABCG1, ACTB, ALZHEIMER DISEASE
Related Diseases	ALS, ATHEROSCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Actin Cytoskeleton Dynamics in Neurodegeneration

mechanism · 3067 words

→

Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (437)

Target	Relation	Type	Str
macrophage activation	drives	process	0.80
microtubule	interacts_with	protein	0.75
Depression	therapeutic_target	disease	0.60
Fibrosis	activates	disease	0.60
Stroke	activates	disease	0.60
Bipolar	therapeutic_target	disease	0.60
Anxiety	therapeutic_target	disease	0.60
Chronic Pain	therapeutic_target	disease	0.60
Neurodegeneration	interacts_with	disease	0.60
Frontotemporal Dementia	inhibits	disease	0.60
Dementia	inhibits	disease	0.60
Amyotrophic Lateral Sclerosis	inhibits	disease	0.60
Ferroptosis	inhibits	disease	0.60
Schizophrenia	interacts_with	disease	0.60
Schizophrenia	transports	disease	0.60
Dementia	transports	disease	0.60
Stroke	transports	disease	0.60
Amyotrophic Lateral Sclerosis	transports	disease	0.60
Epilepsy	transports	disease	0.60
Huntington	transports	disease	0.60
Huntington	interacts_with	disease	0.60
Als	encodes	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Stroke	therapeutic_target	disease	0.60
Chronic Pain	regulates	disease	0.60
Encephalitis	associated_with	disease	0.60
Multiple Sclerosis	associated_with	disease	0.60
Spinal Muscular Atrophy	associated_with	disease	0.60
Dementia	interacts_with	disease	0.60
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Alzheimer	activates	disease	0.60
Schizophrenia	activates	disease	0.60
Depression	activates	disease	0.60
Migraine	activates	disease	0.60
Epilepsy	activates	disease	0.60
Huntington	activates	disease	0.60
Necroptosis	activates	disease	0.60
Aging	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Parkinson	inhibits	disease	0.60
Als	inhibits	disease	0.60
Cancer	inhibits	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Epilepsy	therapeutic_target	disease	0.60
Alzheimer	transports	disease	0.60
Diabetes	protects_against	disease	0.60
Obesity	activates	disease	0.60
Senescence	activates	disease	0.60
Neuropathy	causes	disease	0.60

Incoming (1131)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
Piezo1	positively_regulates	gene	0.70
PIEZO1	regulates	protein	0.64
PPARG	interacts_with	gene	0.60
HK2	activates	gene	0.60
TFEB	interacts_with	gene	0.60
CFTR	regulates	gene	0.60
RICTOR	interacts_with	gene	0.60
SNAP29	associated_with	gene	0.60
HSP70	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
DDIT3	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
LC3	associated_with	gene	0.60
GRB2	interacts_with	gene	0.60
SDC1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
GBM	associated_with	gene	0.60
GFP	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
EPG5	associated_with	gene	0.60
STX17	associated_with	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
GSK3	activates	gene	0.60
GLUT1	activates	gene	0.60
MTORC1	activates	gene	0.60
FOXO	activates	gene	0.60
PKM2	activates	gene	0.60
MYC	activates	gene	0.60
WNT	regulates	gene	0.60
LDL	inhibits	gene	0.60
LDLR	inhibits	gene	0.60
FBXL7	activates	gene	0.60
AURKA	interacts_with	gene	0.60
FOXP1	interacts_with	gene	0.60
SURVIVIN	activates	gene	0.60
TRAF2	interacts_with	gene	0.60
ALPK1	activates	gene	0.60
IL-1	activates	gene	0.60
RAB10	activates	gene	0.60
RAB29	phosphorylates	gene	0.60
LRRK2	phosphorylates	gene	0.60
PARK16	activates	gene	0.60
RNA	interacts_with	gene	0.60
RIPK1	inhibits	gene	0.60
OPTINEURIN	inhibits	gene	0.60
MLKL	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD	0.620	alzheimers	-
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly
Structure-interacting small molecules that stabilize the APO	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTIN in their description or question text

No additional research found