concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1568Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	ACTIN
Key Genes/Proteins	4E-BP1, ABCA1, ABCD3, ABCG1, ACTB, ALZHEIMER DISEASE
Related Diseases	ALS, ATHEROSCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Actin Cytoskeleton Dynamics in Neurodegeneration

mechanism · 3067 words

→

Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (437)

Target	Relation	Type	Str
macrophage activation	drives	process	0.80
microtubule	interacts_with	protein	0.75
Encephalitis	therapeutic_target	disease	0.60
Necroptosis	regulates	disease	0.60
Depression	interacts_with	disease	0.60
Aging	biomarker_for	disease	0.60
Cancer	interacts_with	disease	0.60
Cancer	phosphorylates	disease	0.60
Senescence	inhibits	disease	0.60
Fibrosis	inhibits	disease	0.60
Als	phosphorylates	disease	0.60
Alzheimer	inhibits	disease	0.60
Retinopathy	therapeutic_target	disease	0.60
Prion Disease	interacts_with	disease	0.60
Neurodegeneration	activates	disease	0.60
Bipolar	regulates	disease	0.60
Huntington	interacts_with	disease	0.60
Als	encodes	disease	0.60
Neuroinflammation	activates	disease	0.60
Ischemia	activates	disease	0.60
Alzheimer	causes	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Depression	regulates	disease	0.60
Multiple Sclerosis	regulates	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Diabetes	associated_with	disease	0.60
Ferroptosis	contributes_to	disease	0.60
Obesity	contributes_to	disease	0.60
Huntington	therapeutic_target	disease	0.60
Fibrosis	expressed_in	disease	0.60
Necroptosis	expressed_in	disease	0.60
Ischemia	therapeutic_target	disease	0.60
Fibrosis	regulates	disease	0.60
Tauopathy	stabilizes	disease	0.60
Alzheimer	stabilizes	disease	0.60
Parkinson	activates	disease	0.60
Stroke	activates	disease	0.60
Glioblastoma	associated_with	disease	0.60
Bipolar	therapeutic_target	disease	0.60
Depression	therapeutic_target	disease	0.60
Anxiety	therapeutic_target	disease	0.60
Chronic Pain	therapeutic_target	disease	0.60
Frontotemporal Dementia	associated_with	disease	0.60
Dementia	associated_with	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Aging	activates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Tauopathy	activates	disease	0.60
Amyotrophic Lateral Sclerosis	regulates	disease	0.60

Incoming (1131)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
Piezo1	positively_regulates	gene	0.70
PIEZO1	regulates	protein	0.64
FUS	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
MICROGLIA	activates	gene	0.60
TOLLIP	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
APOA1	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
AMPK	interacts_with	gene	0.60
OVERVIEW	activates	gene	0.60
ABCA1	interacts_with	gene	0.60
MAO	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
ABCG1	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
SPHK1	activates	gene	0.60
TFEB	activates	gene	0.60
ATG	activates	gene	0.60
DEMENTIA	activates	gene	0.60
VCP	activates	gene	0.60
TBK1	activates	gene	0.60
ALS	activates	gene	0.60
DNA	activates	gene	0.60
ALS	interacts_with	gene	0.60
MTOR	activates	gene	0.60
CHMP2B	activates	gene	0.60
TAU	interacts_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD	0.620	alzheimers	-
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly
Structure-interacting small molecules that stabilize the APO	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTIN in their description or question text

No additional research found