concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1588Connections

0Hypotheses

2Analyses

50Outgoing

27Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ACTIN
Summary	Page for Actin Cytoskeleton Dynamics in Neurodegeneration
Key Genes/Proteins	PIEZO1, AMYOTROPHIC LATERAL SCLEROSIS, BECN1, C9ORF72, SMCR8, CALCOCO2
Related Diseases	ALS, FTD

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (447)

Target	Relation	Type	Str
ALS	co_discussed	disease	0.40
AMYOTROPHIC LATERAL SCLEROSIS	co_discussed	gene	0.40
BECN1	co_discussed	gene	0.40
C9ORF72	co_discussed	gene	0.40
SMCR8	co_discussed	gene	0.40
CALCOCO2	co_discussed	gene	0.40
NDP52	co_discussed	gene	0.40
FTD	co_discussed	disease	0.40
DEMENTIA	co_discussed	gene	0.40
FUS	co_discussed	protein	0.40
RNA	co_discussed	gene	0.40
G3BP1	co_discussed	gene	0.40
MAP1LC3	co_discussed	gene	0.40
LC3	co_discussed	protein	0.40
NBR1	co_discussed	gene	0.40
NES	co_discussed	protein	0.40
GNAL	co_discussed	gene	0.40
OPTN	co_discussed	gene	0.40
OPTINEURIN	co_discussed	protein	0.40
SQSTM1	co_discussed	gene	0.40
P62	co_discussed	protein	0.40
TAX1BP1	co_discussed	gene	0.40
TOLLIP	co_discussed	gene	0.40
UBIQUITIN	co_discussed	protein	0.40
ULK1	co_discussed	gene	0.40
NEURODEGENERATION	co_discussed	process	0.40
MTOR	co_discussed	pathway	0.40
RAPAMYCIN	co_discussed	drug	0.40
PINK1	co_discussed	gene	0.40
PTEN	co_discussed	gene	0.40
SPHK1	co_discussed	gene	0.40
TARDBP/TDP-43	co_discussed	protein	0.40
TAR	co_discussed	protein	0.40
DNA	co_discussed	protein	0.40
TBK1	co_discussed	gene	0.40
TFEB	co_discussed	protein	0.40
UNFOLDED PROTEIN RESPONSE	co_discussed	pathway	0.40
UBIQUITIN-PROTEASOME	co_discussed	pathway	0.40
VCP	co_discussed	gene	0.40
VALOSIN	co_discussed	gene	0.40
LYSOSOME	co_discussed	gene	0.40
AMPK	co_discussed	protein	0.40
APOA1	co_discussed	gene	0.40
ATG5	co_discussed	gene	0.40
EIF4EBP1	co_discussed	gene	0.40
4E-BP1	co_discussed	protein	0.40
CHOLESTEROL	co_discussed	pathway	0.40
LOX	co_discussed	gene	0.40
BNIP3L	co_discussed	protein	0.40
CANX	co_discussed	gene	0.40

Incoming (1141)

Source	Relation	Type	Str
PIEZO1	regulates	protein	0.64
TRIM2	co_discussed	gene	0.40
AUTOPHAGY	co_discussed	process	0.40
LATE	co_discussed	disease	0.40
STING	co_discussed	gene	0.40
ACTB	co_discussed	gene	0.40
NEURON	co_discussed	gene	0.40
RELA	co_discussed	gene	0.40
NEURODEGENERATIVE DISEASES	co_discussed	disease	0.40
MYOT	co_discussed	gene	0.40
ATG	co_discussed	gene	0.40
CHMP2B	co_discussed	gene	0.40
FRONTOTEMPORAL DEMENTIA	co_discussed	disease	0.40
P2RY12	co_discussed	gene	0.40
ATHEROSCLEROSIS	co_discussed	disease	0.40
ABCA1	co_discussed	gene	0.40
ABCG1	co_discussed	gene	0.40
ABCD3	co_discussed	gene	0.40
ALZHEIMER DISEASE	co_discussed	gene	0.40
AMBRA1	co_discussed	protein	0.40
ATM	co_discussed	protein	0.40
BCL2	co_discussed	gene	0.40
APOPTOSIS	co_discussed	process	0.40
BCL2L11	co_discussed	gene	0.40
BIM	co_discussed	protein	0.40
BCL2L13	co_discussed	gene	0.40
BNIP3	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

molecular biology | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ACTIN

Understanding Entity Pages

Wiki Pages (21)

Actin Cytoskeleton Dynamics in Neurodegeneration

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings

williams-syndrome

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Oligodendrocytes

Blood-Brain Barrier Dysfunction in Neurodegeneration

ncam2

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

CNTN6 — Contactin 6

dendritic-spines

CNTN4 — Contactin 4

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

Synaptic Vesicle Trafficking in Parkinson's Disease

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

CNTN3 — Contactin 3

MACF1 — Microtubule-actin crosslinking factor 1