concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1568Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	ACTIN
Key Genes/Proteins	4E-BP1, ABCA1, ABCD3, ABCG1, ACTB, ALZHEIMER DISEASE
Related Diseases	ALS, ATHEROSCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Actin Cytoskeleton Dynamics in Neurodegeneration

mechanism · 3067 words

→

Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (437)

Target	Relation	Type	Str
macrophage activation	drives	process	0.80
microtubule	interacts_with	protein	0.75
Epilepsy	activates	disease	0.60
Als	regulates	disease	0.60
Als	expressed_in	disease	0.60
Migraine	activates	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Parkinson	activates	disease	0.60
Cancer	regulates	disease	0.60
Dementia	associated_with	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Ischemia	associated_with	disease	0.60
Depression	activates	disease	0.60
Ischemia	regulates	disease	0.60
Als	transports	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.60
Tauopathy	stabilizes	disease	0.60
Alzheimer	stabilizes	disease	0.60
Aging	associated_with	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Frontotemporal Dementia	associated_with	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Als	activates	disease	0.60
Atherosclerosis	inhibits	disease	0.60
Cancer	activates	disease	0.60
Aging	degrades	disease	0.60
Schizophrenia	activates	disease	0.60
Alzheimer	activates	disease	0.60
Dementia	therapeutic_target	disease	0.60
Neurodegeneration	activates	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60
Alzheimer	interacts_with	disease	0.60
Parkinson	interacts_with	disease	0.60
Dementia	interacts_with	disease	0.60
Als	causes	disease	0.60
Cancer	therapeutic_target	disease	0.60
Als	interacts_with	disease	0.60
Ischemia	activates	disease	0.60
Fibrosis	regulates	disease	0.60
Glioblastoma	associated_with	disease	0.60
Cancer	interacts_with	disease	0.60
Cancer	phosphorylates	disease	0.60
Als	phosphorylates	disease	0.60
Aging	interacts_with	disease	0.60
Neuroinflammation	interacts_with	disease	0.60
Dementia	activates	disease	0.60
Aging	therapeutic_target	disease	0.60
Huntington	activates	disease	0.60

Incoming (1131)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
Piezo1	positively_regulates	gene	0.70
PIEZO1	regulates	protein	0.64
SPHK1	activates	gene	0.60
ATG	activates	gene	0.60
DEMENTIA	activates	gene	0.60
VCP	activates	gene	0.60
ALS	activates	gene	0.60
VALOSIN	activates	gene	0.60
DNA	activates	gene	0.60
OVERVIEW	activates	gene	0.60
MTOR	activates	gene	0.60
CHMP2B	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
PTEN	activates	gene	0.60
ACTB	regulates	gene	0.60
NADH	regulates	gene	0.60
MICROTUBULES	regulates	gene	0.60
NEURON	regulates	gene	0.60
MAP2	contributes_to	gene	0.60
TAU	contributes_to	gene	0.60
MAP6	regulates	gene	0.60
MICROTUBULES	transports	gene	0.60
NEURON	transports	gene	0.60
PPARG	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
SREBF1	regulates	gene	0.60
LAMP1	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CTSD	regulates	gene	0.60
PINK1	activates	gene	0.60
TBK1	activates	gene	0.60
RAS	regulates	gene	0.60
CPT1A	regulates	gene	0.60
RAB7A	regulates	gene	0.60
PPARA	regulates	gene	0.60
CAT	regulates	gene	0.60
MTOR	regulates	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
NEURON	associated_with	gene	0.60
CDK5	causes	gene	0.60
PAFAH1B1	causes	gene	0.60
LIS1	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
DAB1	causes	gene	0.60
AXON	causes	gene	0.60
REELIN	causes	gene	0.60
DCX	causes	gene	0.60
ACSL5	therapeutic_target	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD	0.620	alzheimers	-
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly
Structure-interacting small molecules that stabilize the APO	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTIN in their description or question text

No additional research found