gene

SPP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

451Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

4Experiments

Summary

SPP1 encodes osteopontin, a matricellular protein involved in neuroinflammation, cell survival, and neurodegenerative disease pathogenesis

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🧬 Gene Info

Gene Symbol	Secreted Phosphoprotein 1 (Osteopontin)
Chromosome	4q21.1
Function	encodes a secreted matricellular glycoprotein that functions as a cytokine, chemokine, and extracellular matrix protein.
Amino Acids	314 aa
Pathways	Amyloid, Angiogenesis, Apoptosis, Complement, Immune Response
UniProt ID	P08421
NCBI Gene ID	6696
Ensembl ID	ENSG00000118733
OMIM	166490
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, CCLM, Cancer
Known Drugs/Compounds	rapamycin, ursolic acid, amyloid-beta oligomers, BaP, Bap
Interactions	GRN, C1QA, CTSB, PTEN, GBM, STAT1
SciDEX Hypotheses	Temporal SPP1 Inhibition During Critical Windows
KG Connections	451 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPP1 — AlphaFold P08421 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SPP1["SPP1/Osteopontin<br/>Matricellular Protein"] -->|"activates"| C1QA["C1QA/Complement"]
    SPP1 -->|"activates"| Complement["Complement System"]
    SPP1 -->|"activates"| GRN["GRN/Progranulin"]
    SPP1 -->|"activates"| CTSB["CTSB"]
    SPP1 -->|"activates"| Amyloid["Amyloid Pathology"]

    SPP1 -->|"inhibits"| Angiogenesis["Angiogenesis"]
    SPP1 -->|"expressed in"| Myeloid["Myeloid Cells"]

    CHI3L1["CHI3L1"] -->|"regulates"| SPP1
    GBM["GBM"] -->|"activates"| SPP1
    ICAM1["ICAM1"] -->|"inhibits"| SPP1
    MMP9["MMP9"] -->|"inhibits"| SPP1

    SPP1 -->|"implicated in"| AD["Alzheimer's Disease"]
    SPP1 -->|"implicated in"| ALS["ALS"]
    SPP1 -->|"activates"| Dementia["Dementia"]
    SPP1 -->|"regulates"| Glioblastoma["Glioblastoma"]
    SPP1 -->|"therapeutic target"| Inflammation["Neuroinflammation"]

    style SPP1 fill:#e74c3c,stroke:#c0392b,color:#e0e0e0
    style C1QA fill:#3498db,stroke:#2980b9,color:#e0e0e0
    style Complement fill:#3498db,stroke:#2980b9,color:#e0e0e0
    style AD fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0
    style ALS fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0
    style Inflammation fill:#f39c12,stroke:#e67e22,color:#e0e0e0

Outgoing (286)

Target	Relation	Type	Str
SYNAPTIC ENGULFMENT	mediates	entity	0.95
ALZHEIMER'S DISEASE	implicated_in	entity	0.95
PHAGOCYTOSIS	regulates	entity	0.95
Microglial Phagocytic States	associated_with	process	0.95
Microglial Phagocytosis	activates	process	0.95
Microglial Phagocytosis	promotes	process	0.95
microglial phagocytosis	drives	process	0.95
Macrophage Inflammation	promotes	process	0.95
Lipid Dysregulation	promotes	phenotype	0.95
ALZHEIMER'S DISEASE	involved_in	disease	0.95
Synaptic Engulfment	mediates	process	0.95
Th17 cell differentiation	promotes	process	0.95
Atherosclerosis	contributes_to	disease	0.95
CD44	binds_to	protein	0.93
microglial phagocytic state	associated_with	phenotype	0.93
ITGB1	binds_to	protein	0.93
synaptic engulfment	promotes	process	0.92
Microglia	modulates	cell_type	0.92
ERK	activates	protein	0.92
C1Q	upregulates	entity	0.90
HIPPOCAMPUS	expressed_in	entity	0.90
Synaptic Loss	contributes_to	phenotype	0.90
C1QA	upregulates	gene	0.90
GRN	upregulates	gene	0.90
CTSB	upregulates	gene	0.90
macrophage inflammation	promotes	process	0.90
MICROGLIA	mediates	cell_type	0.90
Inflammation	promotes	process	0.90
microglia	induces	cell_type	0.90
PI3K/Akt/mTOR pathway	activates	pathway	0.90
idiopathic pulmonary fibrosis	causes	disease	0.90
NSCLC	causes	disease	0.90
Phagocytic Markers	upregulates	biomarker	0.90
Alzheimer's Disease	therapeutic_target	disease	0.88
Microglial Phagocytosis	upregulates	process	0.88
lipid dysregulation	mediates	phenotype	0.85
Macrophage Cytotoxicity	mediates	phenotype	0.85
Alzheimer'S Disease	involved_in	disease	0.85
foam cell phenotype	promotes	phenotype	0.80
Microglia	associated_with	cell_type	0.80
MICROGLIA	induces_phagocytic_states	cell_type	0.80
atherosclerosis	therapeutic_target	disease	0.80
phagocytic_state	induces	biological_process	0.80
ABCA1	suppresses	gene	0.75
CD36	upregulates	gene	0.75
PLIN2	upregulates	gene	0.75
Senescence	activates	disease	0.75
RAGE	therapeutic_target	gene	0.70
MICROGLIA	associated_with	gene	0.70
microglia	expressed_in	cell_type	0.70

Incoming (165)

Source	Relation	Type	Str
PERIVASCULAR MACROPHAGES	expressed_in	entity	0.95
BaP	upregulates	compound	0.95
Bap	upregulates	compound	0.95
Mir-692	inhibits	biomarker	0.95
ursolic acid	inhibits	drug	0.91
PERIVASCULAR FIBROBLASTS	expressed_in	entity	0.90
perivascular_cells	upregulates	cell_type	0.90
Perivascular Macrophages	upregulates	cell_type	0.90
Bap	binds	compound	0.90
Perivascular Fibroblasts	upregulates	cell_type	0.85
Perivascular Cells	expressed_in	cell_type	0.85
BaP	binds	compound	0.85
RPS18	co_expressed_with	gene	0.80
MICROGLIA	induces	cell_type	0.80
amyloid-beta oligomers	modulates	compound	0.80
C1QA	regulates	entity	0.60
CTSB	regulates	entity	0.60
GRN	regulates	entity	0.60
CTSB	activates	gene	0.60
C1QA	activates	gene	0.60
CAMK4	associated_with	gene	0.60
CD8	associated_with	gene	0.60
RB1	therapeutic_target	gene	0.60
CHI3L1	regulates	gene	0.60
GBM	activates	gene	0.60
STAT3	regulates	gene	0.60
RAGE	therapeutic_target	gene	0.60
SERPINE1	inhibits	gene	0.60
NOS2	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
KDR	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
ICAM1	inhibits	gene	0.60
GRN	activates	gene	0.60
CAMK4	therapeutic_target	gene	0.60
CD8	therapeutic_target	gene	0.60
MMP3	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CD4	regulates	gene	0.60
CD44	regulates	gene	0.60
TREM2	activates	gene	0.60
CD8	activates	gene	0.60
HMOX1	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
KIF20A	associated_with	gene	0.60
MCC	therapeutic_target	gene	0.60
SLC7A11	associated_with	gene	0.60
YBX1	activates	gene	0.60
ANXA2	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Temporal SPP1 Inhibition During Critical Windows	0.650	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (4)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

synaptic biology | 2026-04-07 | 0 hypotheses

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 0 hypotheses

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-06 | 0 hypotheses

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
SPP1-mediated microglial synaptic engulfment assay	exploratory	Alzheimer's disease	0.950	AD mouse models with amyloid-β	proposed	N/A
SPP1 upregulation in perivascular cells in AD mouse models	exploratory	Alzheimer's disease	0.900	AD mouse models	proposed	N/A
Single-cell RNA sequencing of microglial states in AD hippocampus	exploratory	Alzheimer's disease	0.850	AD mouse hippocampus	proposed	N/A
Cell-cell interaction analysis of perivascular-microglial crosstalk	exploratory	Alzheimer's disease	0.800	AD mouse models	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SPP1

Understanding Entity Pages

Summary

Wiki Pages (21)

SPP1 Gene

Osteopontin (SPP1)

MS4A6A Gene

Microglial Polarization

SLC9A1 — Sodium/Hydrogen Exchanger 1

Vascular Smooth Muscle Cells

KDR Gene

Disease-Associated [Microglia](/cell-types/microglia-neuroinflammation) (DAM)

TREM2 Protein — Triggering Receptor Expressed on Myeloid Cells 2

SYNA — Synapsin I

Microglia in Chronic Neuroinflammation

CLEC7A Gene

Neurodegeneration-Associated Microglia (NAM)

Lateral Superior Olive (LSO) Neurons

Dementia with Lewy Bodies Knowledge Gaps

Medial Nucleus of the Trapezoid Body (MNTB) Neurons

RPS18 — Ribosomal Protein S18

KIF20A — Kinesin Family Member 20A

Trapezoid Body Complex

CTSB Protein

Perivascular Macrophages

Pathway Diagram

Outgoing (286)

Incoming (165)

Targeting Hypotheses (1)

Mentioning Analyses (4)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

How do perivascular cells specifically recognize and respond to amyloid-β to upr

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Experiments (4)

Related Papers (0)