FOXO3

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXO3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

FOXO3 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, Aging, Als. Connected to 480 entities in the SciDEX knowledge graph.

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flowchart TD
    FOXO3(["FOXO3"])
    Als["Als"]
    Ferroptosis("Ferroptosis")
    Mitochondrial_Gene_Expression("Mitochondrial Gene Expression")
    h_fd52a7a0["h-fd52a7a0"]
    SIRT1(["SIRT1"])
    Aging["Aging"]
    Cancer["Cancer"]
    Tumor["Tumor"]
    SLC7A11(["SLC7A11"])
    Mitochondrial_Dysfunction("Mitochondrial Dysfunction")
    Trifluoperazine{"Trifluoperazine"}
    AMPK(["AMPK"])

    FOXO3 -->|"activates"| Als
    FOXO3 -.->|"inhibits"| Ferroptosis
    FOXO3 -->|"regulates"| Mitochondrial_Gene_Expression
    h_fd52a7a0 -->|"therapeutic target"| FOXO3
    SIRT1 -->|"associated with"| FOXO3
    SIRT1 -->|"interacts with"| FOXO3
    h_fd52a7a0 -->|"targets gene"| FOXO3
    FOXO3 -->|"activates"| Aging
    FOXO3 -->|"activates"| Cancer
    FOXO3 -->|"activates"| Tumor
    FOXO3 -->|"binds"| SLC7A11
    FOXO3 -.->|"downregulates"| SLC7A11
    FOXO3 -->|"involved in"| Mitochondrial_Dysfunction
    Trifluoperazine -->|"activates"| FOXO3
    AMPK -->|"activates"| FOXO3

    style FOXO3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0