gene

HK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

810Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

HK2 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with ALS, Aging, Als. Connected to 408 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HK2
Full Name	Hexokinase 2
Chromosome	2p12
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitor of glucose phosphorylation
Mechanism of Action	Small molecule inhibitor of glucose phosphorylation
Primary Expression	Brain, Muscle, Fat
Druggability	Low (0.38)
Clinical Stage	Phase III
Pathways	Akt, Apoptosis, Epigenetic, Erk Signaling, Glucose Metabolism
UniProt ID	P19367
NCBI Gene ID	3099
Ensembl ID	ENSG00000149718
GeneCards	HK2
Human Protein Atlas	HK2
Associated Diseases	ALS, Acute Kidney Injury, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compounds	ADUCANUMAB, aducanumab
Interactions	MYC, FASN, HK1, AKT, SRC, SPR
SciDEX Target	View Target Profile (10 clinical trials)
SciDEX Hypotheses	Metabolic Switch Targeting for A1→A2 Repolarizatio Metabolic Reprogramming via Microglial Glycolysis
KG Connections	810 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: HK2 — PDB 2NZT Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HK2["HK2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    HK2["HK2"] -->|"co discussed"| MIRO1["MIRO1"]
    HK2["HK2"] -->|"co discussed"| P2RY1["P2RY1"]
    HK2["HK2"] -->|"co discussed"| SOAT1["SOAT1"]
    HK2["HK2"] -->|"co discussed"| KCNK2["KCNK2"]
    HK2["HK2"] -->|"co discussed"| TET2["TET2"]
    BMAL1["BMAL1"] -->|"co discussed"| HK2["HK2"]
    style HK2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (559)

Target	Relation	Type	Str
Cancer	activates	disease	1.00
Glycolysis	activates	pathway	1.00
CANCER	activates	gene	1.00
VDAC	interacts_with	protein	0.95
Metabolic Stress	mediates	process	0.95
Histone Lactylation	mediates	mechanism	0.95
Hepatic Stellate Cell Activation	associated_with	process	0.95
glycolysis	drives	pathway	0.95
Ubiquitin-Proteasome System	associated_with	pathway	0.95
Tumor	activates	disease	0.95
GLYCOLYSIS	involved_in	entity	0.95
MITOCHONDRIAL FUNCTION	modulates	entity	0.92
mitophagy	regulates	process	0.92
Histone Lactylation	regulates	process	0.90
glucose metabolism	involved_in	process	0.90
Glycolysis	involved_in	process	0.90
NEURODEGENERATION	therapeutic_target	entity	0.90
MACROPHAGE	expressed_in	entity	0.90
Glycolysis	upregulates	pathway	0.90
AKT	activates	gene	0.90
PI3K	activates	gene	0.90
GENES	activates	gene	0.90
Pi3K/Akt	activates	pathway	0.90
MASLD	associated_with	disease	0.88
Inflammation	upregulates	process	0.88
Liver Macrophages	expressed_in	cell_type	0.85
Inflammation Burden	regulates	phenotype	0.85
Renal Ischemia-Reperfusion Injury	contributes_to	disease	0.85
Lactate Production	regulates	process	0.85
Gene Expression	regulates	process	0.85
Lactate	associated_with	compound	0.85
Acute Kidney Injury	associated_with	disease	0.85
Metabolic Dysfunction-Associated Fatty Liver Disease	implicated_in	disease	0.85
Tumor Metastasis	involved_in	phenotype	0.85
Als	activates	disease	0.85
Tumor	associated_with	disease	0.85
Cancer	inhibits	disease	0.85
NEUROINFLAMMATION	mediates	entity	0.85
NEURODEGENERATION	associated_with	entity	0.85
inflammation	promotes	process	0.85
Aerobic Glycolysis	involved_in	process	0.80
Lactate	regulates	compound	0.80
Acute Kidney Injury	contributes_to	disease	0.80
Renal Function	regulates	phenotype	0.80
glucose-dependent signaling	mediates	process	0.80
AGING	associated_with	entity	0.80
glycolysis	rate_limits	pathway	0.80
Mtor	activates	pathway	0.80
Proximal Tubular Cells	expressed_in	cell_type	0.75
Als	therapeutic_target	disease	0.75

Incoming (251)

Source	Relation	Type	Str
Phds	degrades	drug	0.95
AST-120	downregulates	drug	0.90
PINK1	interacts_with	gene	0.90
Pi3K/Akt Pathway	phosphorylates	pathway	0.90
RGFP966	downregulates	drug	0.90
Retinitis Pigmentosa progression	downregulates	phenotype	0.90
Glucose Metabolism	regulates	process	0.90
Chnds	degrades	drug	0.90
PI3K/AKT	phosphorylates	pathway	0.90
h-a1b56d74	targets_gene	hypothesis	0.90
h-38292315	targets_gene	hypothesis	0.90
h-var-ac50d1e3d1	targets_gene	hypothesis	0.90
HIF1A	upregulates	gene	0.88
STAT3	upstream_of	protein	0.85
Mdivi-1	downregulates	drug	0.85
STAT3	regulates	protein	0.80
h-a1b56d74	targets	hypothesis	0.80
h-38292315	targets	hypothesis	0.80
KLF14	inhibits	gene	0.80
H3K18 Lactylation	upregulates	process	0.80
glucose metabolism	modulates	process	0.80
PAL	upregulates	compound	0.80
glucose metabolism	activates	process	0.80
PTEN	activates	gene	0.80
STING	activates	gene	0.70
CANCER	inhibits	gene	0.70
MITOPHAGY	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
ASTROCYTE	activates	cell_type	0.70
HDAC3	regulates	gene	0.65
LACTATE	inhibits	phenotype	0.65
LACTATE	treats	phenotype	0.65
ROS	treats	phenotype	0.65
FASN	activates	gene	0.60
SRC	activates	gene	0.60
HK1	activates	gene	0.60
MTOR	activates	gene	0.60
HK1	interacts_with	gene	0.60
TNF	inhibits	gene	0.60
SPR	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
PINK1	activates	gene	0.60
AKT	associated_with	gene	0.60
FASN	associated_with	gene	0.60
LGMN	interacts_with	gene	0.60
PPP1CB	inhibits	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Metabolic Switch Targeting for A1→A2 Repolarization	0.481	neurodegeneration	Astrocyte reactivity subtypes in neurode
Metabolic Reprogramming via Microglial Glycolysis Inhibition	0.385	neurodegeneration	Synaptic pruning by microglia in early A

Mentioning Analyses (2)

Scientific analyses that reference this entity

Synaptic pruning by microglia in early AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.503

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.554

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-d [PMID:41520557]	Sun B, Zhang A, Feng S, Jamali AW, Jia Z	Int Immunopharmacol	2026	1
HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352]	Pesce NA, Seminara G, Giarrusso G, Tomas	Adv Biol (Weinh)	2026	1
Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285]	Fang M, Zhou Y, He K, Lu Y, Tao F, Huang	Mol Neurobiol	2025	1
Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroin [PMID:40911376]	Sun L, Wang X, Guan S, Zhang P, Chen D,	FASEB J	2025	1
Hexokinase 2-mediated metabolic stress and inflammation burden of liver macropha [PMID:40014451]	Li J, Chen X, Song S, Jiang W, Geng T, W	Cell Rep	2025	1
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014]	Fontana F, Giannitti G, Marchesi S, Limo	Int J Biol Sci	2024	1
AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated [PMID:39217289]	Zhou J, Zhang J, Xu F, Gao H, Wang L, Zh	Mol Med	2024	1
Hexokinase 2-mediated gene expression via histone lactylation is required for he [PMID:37463576]	Rho H, Terry AR, Chronis C, Hay N	Cell Metab	2023	1
Metabolic phenotype of bladder cancer. [PMID:26975021]	Massari F, Ciccarese C, Santoni M, Iacov	Cancer Treat Rev	2016	1
Crosstalk Between [PMID:41899603]	["Ren Y", "Tang D", "Ding X", "He M"]	Cancers	2026	0
Suoquan Yishen formula attenuates ectopic lipid deposition in diabetic kidney di [PMID:41461331]	Wang J, Lin N, Li X, Ma T, Yuan Y et al.	J Ethnopharmacol	2026	0
Yi-Shen-Hua-Shi granules ameliorate renal injury via PPARγ-Klotho-mediated metab [PMID:41475627]	Gao HZ, Sun LM, Hu D, Li J, Chen CL et a	J Ethnopharmacol	2026	0
Bisphenol A Promotes Ovarian Cancer Proliferation and Migration through the HK2/ [PMID:41885081]	Xie X, Zhang Y, Li Y, Yan Q, Dong J et a	J Agric Food Chem	2026	0
Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: [PMID:41936633]	Tang Y, Wang S, Wang Y, Zhang T, Liu Y e	Histochem Cell Biol	2026	0
SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic [PMID:41945160]	Jian Y, Zeng Y, Wang Z, Zhou X, Zhang H	Apoptosis	2026	0
Nuclear hexokinase 2 couples hyperglycemia to MYC-driven glycolytic and stemness [PMID:41951587]	Liu S, Liu X, Liu G, Wang Z, Li C et al.	Cell Death Dis	2026	0
Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reduc [PMID:41958068]	Gong D, Chen X, Dong Z, Chen H, Liu Z	Ren Fail	2026	0
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates [PMID:41960638]	Lin W, Dong C, Jiang Q, Lou Y, Wang L et	Redox Rep	2026	0
Modulation of Aerobic Glycolysis Genes During the Progression of Retinitis Pigme [PMID:41569027]	["Adani E", "Villa Vasquez S", "Lovino M	Investigative ophthalmology &	2026	0
Duzhong-Gegen formula ameliorated hyperuricemia by enhancing renal uric acid exc [PMID:41905095]	Wang L, Gan Y, Huang J, Long L, Li S, Wa	Phytomedicine : international	2026	0

HK2

Understanding Entity Pages

Summary

Wiki Pages (21)

HK2

Insulin Signaling in Parkinson's Disease

TREM2 Signaling in Neurodegeneration

KDM3A Gene (JMJD1A)

TBX2 — T-Box Transcription Factor 2

ROCK2 Gene

Insulin Signaling Pathway in Neurodegeneration

Mitochondrial Dysfunction in ALS-FTD Spectrum

Insulin Signaling Pathway in Neurodegeneration

SLC2A1 Gene

LRRK2 Kinase-Targeting Therapies

Insulin and IGF Signaling in 4R-Tauopathies

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

FUS-Targeting Therapies for Amyotrophic Lateral Sclerosis

insulin-resistance-ad

AKT1 Protein

LGMN Gene

STAT3 Gene

HIF Signaling in Neurodegeneration

Insulin-Responsive Neurons

PSP/CBS Therapeutic Target Index