disease

Nephropathy

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Nephropathy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

221Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	DIABETES MELLITUS, AUTOPHAGY, OPTN, INFLAMMATION, OXIDATIVE STRESS, STROKE, MITOCHONDRIAL DYSFUNCTION, ROS
Therapeutic Agents	Telmisartan, Aconite
KG Connections	221 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Nephropathy["Nephropathy"] -->|"therapeutic target"| Oxidative_Stress["Oxidative Stress"]
    Nephropathy["Nephropathy"] -->|"causes"| Diabetes["Diabetes"]
    Nephropathy["Nephropathy"] -->|"associated"| Diabetes_1["Diabetes"]
    Nephropathy["Nephropathy"] -->|"activates"| Ferroptosis["Ferroptosis"]
    Nephropathy["Nephropathy"] -->|"treats"| Als["Als"]
    Nephropathy["Nephropathy"] -->|"treats"| Inflammation["Inflammation"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Nephropathy["Nephropathy"]
    INFLAMMATION["INFLAMMATION"] -->|"treats"| Nephropathy["Nephropathy"]
    INSULIN_RESISTANCE["INSULIN RESISTANCE"] -->|"therapeutic target"| Nephropathy["Nephropathy"]
    CYTOKINES["CYTOKINES"] -->|"therapeutic target"| Nephropathy["Nephropathy"]
    style Nephropathy fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (84)

Target	Relation	Type	Str
Oxidative Stress	therapeutic_target	pathway	0.90
Diabetes	causes	disease	0.85
Diabetes	associated_with	disease	0.85
Ferroptosis	activates	pathway	0.70
Als	treats	disease	0.65
Inflammation	treats	disease	0.65
Insulin Resistance	therapeutic_target	disease	0.65
Diabetes	implicated_in	disease	0.65
Als	therapeutic_target	disease	0.65
Type 2 Diabetes	associated_with	disease	0.65
Oxidative Stress	treats	pathway	0.60
Autophagy	treats	pathway	0.60
Apoptosis	treats	pathway	0.60
Pi3K/Akt	treats	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Insulin Signaling	therapeutic_target	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Mitophagy	therapeutic_target	pathway	0.60
Wnt	activates	pathway	0.60
Autophagy	associated_with	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Autophagy	inhibits	pathway	0.60
Mitophagy	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Oxidative Stress	inhibits	pathway	0.60
Lipid Metabolism	causes	pathway	0.60
Oxidative Stress	causes	pathway	0.60
Mitochondrial Function	causes	pathway	0.60
Phagocytosis	activates	pathway	0.60
Immune Response	activates	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Ferroptosis	associated_with	pathway	0.60
Cholesterol	therapeutic_target	pathway	0.60
Immune Response	treats	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Tgf-Β	inhibits	pathway	0.60
Chronic Kidney Disease	implicated_in	disease	0.55
Glomerulonephritis	implicated_in	disease	0.55
Diabetes	contributes_to	disease	0.55

Incoming (137)

Source	Relation	Type	Str
OXIDATIVE STRESS	therapeutic_target	gene	0.95
Doxorubicin	causes	drug	0.90
INFLAMMATION	treats	gene	0.75
INSULIN RESISTANCE	therapeutic_target	gene	0.75
CYTOKINES	therapeutic_target	gene	0.75
DIABETES MELLITUS	causes	gene	0.75
INFLAMMATION	activates	gene	0.75
SIRT1	inhibits	gene	0.75
FERROPTOSIS	activates	gene	0.75
HO-1	activates	gene	0.75
NRF2	activates	gene	0.75
GENES	associated_with	gene	0.75
Telmisartan	treats	drug	0.75
Aconite	treats	compound	0.70
AUTOPHAGY	treats	gene	0.65
APOPTOSIS	treats	gene	0.65
OXIDATIVE STRESS	treats	gene	0.65
PI3K	treats	gene	0.65
AKT	treats	gene	0.65
TNF	therapeutic_target	gene	0.65
PI3K	therapeutic_target	gene	0.65
NF-ΚB	therapeutic_target	gene	0.65
IL-6	therapeutic_target	gene	0.65
INFLAMMATION	interacts_with	gene	0.65
TNF-Α	therapeutic_target	gene	0.65
AKT	therapeutic_target	gene	0.65
JAK	therapeutic_target	gene	0.65
MTOR	therapeutic_target	gene	0.65
Fibrosis	therapeutic_target	disease	0.65
AKT	inhibits	gene	0.65
PI3K	inhibits	gene	0.65
DIABETES MELLITUS	protects_against	gene	0.65
APOPTOSIS	inhibits	gene	0.65
AMPK	therapeutic_target	gene	0.65
MITOPHAGY	therapeutic_target	gene	0.65
AUTOPHAGY	therapeutic_target	gene	0.65
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.65
MITOCHONDRIA	therapeutic_target	gene	0.65
RHOA	activates	gene	0.65
ROCK1	activates	gene	0.65
WNT3A	activates	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
OPTN	associated_with	gene	0.65
OXIDATIVE STRESS	activates	gene	0.65
NF-ΚB	activates	gene	0.65
Inflammation	activates	disease	0.65
STAT3	inhibits	gene	0.65
NF-ΚB	inhibits	gene	0.65
MITOPHAGY	activates	gene	0.65
ROS	activates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Nephropathy

Understanding Entity Pages

Wiki Pages (20)

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