gene

CS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

30Hypotheses

13Analyses

40Outgoing

8Incoming

5Experiments

17Debates

Summary

CS encodes citrate synthase, a key mitochondrial enzyme in the TCA cycle with important roles in neuronal energy metabolism and neurodegeneration.

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🧬 Gene Info

Gene Symbol	CS
Full Name	Citrate Synthase
Chromosome	12p15
Protein Type	Enzyme
Function	is a nuclear-encoded gene located on chromosome 12p15 that encodes citrate synthase, a key mitochondrial enzyme that catalyzes the first committed step of the citric acid cycle (TCA cycle).
Primary Expression	virtually all tissues with high activity in: - Heart: Highest expression (high energy demand) - Liver: Central metabolic hub - Kidney: Act
Amino Acids	466 aa
UniProt ID	O75390
NCBI Gene ID	1451
Ensembl ID	ENSG00000143228
OMIM	118950
GeneCards	CS
Human Protein Atlas	CS
N-terminal domain	Contains the binding site for acetyl-CoA
C-terminal domain	Contains the oxaloacetate binding site
Associated Diseases	Huntington's disease, neurodegeneration
Known Drugs/Compounds	quercetin, rapamycin
Interactions	AKT, BDNF, CALCOCO2, CDKN1A, CDKN2A, CXCL1
KG Connections	48 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CS — AlphaFold O75390 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CS Gene

gene · 798 words

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Validated Hypothesis: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD

hypothesis · 5450 words

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Validated Hypothesis: 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Disease-Associated Microglia

hypothesis · 4761 words

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Validated Hypothesis: ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzheimer's Disease

hypothesis · 4717 words

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Validated Hypothesis: ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia

hypothesis · 4709 words

→

Validated Hypothesis: CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion

hypothesis · 4553 words

→

Pathway Diagram

flowchart TD
    N0["CS"]
    N1["neurodegeneration"]
    N0 -->|"associated with"| N1
    N2["PINK1"]
    N0 -->|"activates"| N2
    N3["PRKN"]
    N0 -->|"activates"| N3
    N4["senescence"]
    N0 -->|"participates in"| N4
    N5["CXCL1"]
    N0 -->|"activates"| N5
    N6["CXCL8"]
    N0 -->|"activates"| N6
    N7["GLB1"]
    N0 -->|"activates"| N7
    N8["LC3"]
    N0 -->|"activates"| N8

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 pathway
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene

Outgoing (40)

Target	Relation	Type	Str
neurodegeneration	associated_with	disease	0.70
PRKN	activates	gene	0.60
CXCL1	activates	gene	0.60
CXCL8	activates	gene	0.60
GLB1	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
NDP52	activates	gene	0.60
OPTN	activates	gene	0.60
PTEN	activates	gene	0.60
TNF	activates	gene	0.60
DRP1	associated_with	gene	0.60
MFF	associated_with	gene	0.60
MFN2	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
PI3K	activates	gene	0.60
neuroinflammation	activates	disease	0.60
neurodegeneration	causes	disease	0.60
mitochondrial function	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
GSH	activates	gene	0.60
PINK1	activates	gene	0.60
lipid metabolism	participates_in	pathway	0.60
TH	associated_with	gene	0.60
PYCARD	activates	gene	0.60
RNA	regulates	gene	0.60
neurodegeneration	activates	disease	0.60
senescence	participates_in	pathway	0.60
MAP1LC3	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
IGF1R	associated_with	gene	0.60
ROS	activates	gene	0.60
RNA	associated_with	gene	0.60
Huntington's disease	associated_with	disease	0.60
stem cells	expressed_in	cell_type	0.55
macrophages	expressed_in	cell_type	0.55

Incoming (8)

Source	Relation	Type	Str
AKT	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CDKN1A	activates	gene	0.60
CDKN2A	activates	gene	0.60
BDNF	activates	gene	0.60
rapamycin	targets	drug	0.60
quercetin	targets	drug	0.60
AGER	associated_with	gene	0.35

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.891	alzheimers	Cell type vulnerability in Alzheimers Di
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.869	alzheimers	Circuit-level neural dynamics in neurode
Elevated CSF/Serum Albumin Quotient Predicts Neurodegenerati	0.850	-	What blood-brain barrier permeability ch
STING Antagonists as ALS Therapeutics: Drug Repurposing	0.821	neuroinflammation	How does chronic cGAS/STING activation d
HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43	0.820	neurodegeneration	What is the therapeutic window between i

Closed-loop tACS targeting EC-II PV interneurons to suppress	0.811	alzheimers	Circuit-level neural dynamics in neurode
CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion	0.808	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2,	0.807	biomarkers	What biomarkers can reliably detect micr
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.801	neuroimmunology	TREM2 in Alzheimer's Disease: Mechanisms
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	alzheimers	Cell type vulnerability in Alzheimers Di
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.801	alzheimers	Cell type vulnerability in Alzheimers Di
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.795	neurodegeneration	APOE4 structural biology and therapeutic
Senescent Microglia Resolution via Maresins-Senolytics Combi	0.791	neurodegeneration	Neuroinflammation resolution mechanisms
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	alzheimers	Circuit-level neural dynamics in neurode
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	alzheimers	Cell type vulnerability in Alzheimers Di
Closed-loop tACS targeting EC-II SST interneurons to block t	0.752	alzheimers	Circuit-level neural dynamics in neurode
Tau/MAP6 ratio as a master switch for microtubule dynamics p	0.750	neurodegeneration	-
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.748	neurodegeneration	Gene expression changes in aging mouse b
KCNQ2/3 (M-current) Channel Restoration Reactivates Theta Os	0.725	alzheimers	Closed-loop optogenetic targeting PV int
TDP-43 condensation thermodynamics as a therapeutic target a	0.724	neuroscience	How can subcellular compartmentalization
CSF YKL-40 as a Priming-Specific Chitinase Marker	0.723	biomarkers	What biomarkers can reliably detect micr
Interfacial Lipid Mimetics to Disrupt Domain Interaction	0.723	neurodegeneration	APOE4 structural biology and therapeutic
ACSL4 lipid remodeling creates ferroptosis-prone ALS membran	0.710	neurodegeneration	Ferroptosis in ALS motor neuron vulnerab
CSF/Plasma AQP4 Polarization Index as a Novel Biomarker of A	0.705	-	What blood-brain barrier permeability ch
CSF Soluble TREM2 Fragment Ratio as Priming State Indicator	0.689	biomarkers	What biomarkers can reliably detect micr
Lysosomal Positioning Dynamics Modulation	0.686	neurodegeneration	Autophagy-lysosome pathway convergence a
GPX4 Selenopeptide Mimetics as Neuroprotective Ferroptosis B	0.680	-	Ferroptosis in ALS and motor neuron dise
Matrix Metalloproteinase-9/TIMP-1 Ratio in CSF Identifies Pr	0.675	-	What blood-brain barrier permeability ch
Lipid Droplet Dynamics as Phenotype Switches	0.666	neurodegeneration	Astrocyte reactivity subtypes in neurode
eIF2α Phosphorylation Imbalance Disrupts Mitochondrial Prote	0.000	als	-

Mentioning Analyses (13)

Scientific analyses that reference this entity

Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Cau

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.585

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.940

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.745

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.362

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice	validation	Alzheimer's disease	0.900	5xFAD transgenic mice	proposed	N/A
Transcriptomic profiling and differential expression analysis	exploratory	Alzheimer's disease	0.900	1-month-old APP/PS1 mice cereb	proposed	N/A
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	cultured cells under arsenite	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	mouse models of Alzheimer's di	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	human brain tissue	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445]	Qin J, Ma S, Wang J, Huang S, Luan J, He	Cell death & disease	2026	0
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795]	Gao C, Liu B, Zhang R, Tian J, Xin H	Toxicology mechanisms and meth	2026	0
Activation of stimulator of interferon genes (STING) and inhibition of vascular [PMID:41380972]	Wang Y, Hou Y, Han J, Zhang Z, Cheng Y e	J Biol Chem	2026	0
cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960]	Fazal F, Dar NJ, Ahamad S, Khan S, Bano	Mol Aspects Med	2026	0
Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397]	Lu C, Wang W, Fu YX	Nat Rev Cancer	2026	0
cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413]	Solomon J, Mandal S, Aran KR	Gene	2026	0
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890]	Rao W, Huang Y, Li J, Chen Q, Sun J et a	J Stroke Cerebrovasc Dis	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053]	Ye R, Wang S, Hu Y, Pan Y, Zheng W et al	Science	2026	0
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496]	Che L, Zhu L, Zhou L, Zhou Y	Biochim Biophys Acta Rev Cance	2026	0
The cGAS-STING signaling pathway: A central regulator and novel therapeutic targ [PMID:41765111]	Jiang H, Ji Y, Shang T, Qi L, Li Z et al	Biochem Pharmacol	2026	0
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570]	Chien Y, Xia R, Zhou D, Ai Y, Wu L et al	Hepatol Commun	2026	0
cGAS-STING and PANoptosis: Interplay, Underlying Mechanisms, and Therapeutic Tar [PMID:42016387]	Wang Y, Chen J, Feng W, Li N, Zhang X et	Drug Des Devel Ther	2026	0
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558]	Singh P, Rath SL	Journal of Alzheimer's disease	2026	0
Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334]	Song C, Wu X, Chen C, Shen B, He Y, Liu	Drug design, development and t	2026	0
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914]	["Xin R", "Zhang J", "Zhang Y", "Dai M",	Free radical biology & medicin	2026	0
Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086]	Wang Y, Zhang W, Zhang M, Zhu Y, Wang W,	Tissue & cell	2026	0
Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362]	Xu J, Sun M, Wang C, Ju P, Guan XD, Xie	International journal of ophth	2026	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0

Debates (17)

Multi-agent debates referencing this entity

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream

closed · Rounds: 4 · Score: 0.64 · 2026-04-28

What is the evidence that blood-brain barrier (BBB) permeability changes serve a

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Formal debate: plasma GFAP separates causal from compensatory states in: Blood-b

closed · Rounds: 3 · Score: 0.75 · 2026-04-26

Formal debate: tight-junction remodeling is the actionable driver in: Blood-brai

closed · Rounds: 3 · Score: 0.75 · 2026-04-26

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

closed · Rounds: 4 · Score: 0.78 · 2026-04-26

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

closed · Rounds: 7 · Score: 0.50 · 2026-04-26

Which specific CSF molecular components are essential for maintaining disease-re

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

Related Research

Hypotheses and analyses mentioning CS in their description or question text

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

Score: 0.811 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagat

CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion

Score: 0.808 · neurodegeneration · 2026-04-16

## Mechanistic Overview CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion starts from the claim that modulating

Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin

Score: 0.807 · biomarkers · 2026-04-22

## Mechanistic Overview Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin starts from the cla

CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification

Score: 0.801 · neuroimmunology · 2026-04-15

## Mechanistic Overview CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification starts from the cl

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degen

Score: 0.801 · alzheimers · 2026-04-05

## Mechanistic Overview ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzhe

40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively

Score: 0.801 · alzheimers · 2026-04-05

## Mechanistic Overview 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Diseas

Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

Score: 0.795 · neurodegeneration · 2026-04-02

## Mechanistic Overview Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs) starts from the claim t

Senescent Microglia Resolution via Maresins-Senolytics Combination

Score: 0.791 · neurodegeneration · 2026-04-02

## Mechanistic Overview Senescent Microglia Resolution via Maresins-Senolytics Combination starts from the claim that mo

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Score: 0.784 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophag

ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlie

Score: 0.779 · alzheimers · 2026-04-05

## Mechanistic Overview ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlies White Matter D

Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

Score: 0.752 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant

TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming

Score: 0.748 · neurodegeneration · 2026-04-12

**Molecular Mechanism and Rationale** The TREM2-CSF1R metabolic cross-talk hypothesis centers on the intricate molecula

KCNQ2/3 (M-current) Channel Restoration Reactivates Theta Oscillation Dynamics

Score: 0.725 · alzheimers · 2026-04-28

Aβ oligomers downregulate KCNQ2/3 voltage-gated potassium channels on PV interneurons via PKC-dependent phosphorylation,

TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc

Score: 0.724 · neuroscience · 2026-04-26

FRAP-based measurement of TDP-43 liquid-liquid phase separation state provides a continuous biomarker of nuclear-cytopla

CS

Understanding Entity Pages

Summary

Wiki Pages (21)

CS Gene

Validated Hypothesis: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD

Validated Hypothesis: 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Disease-Associated Microglia

Validated Hypothesis: ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzheimer's Disease

Validated Hypothesis: ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia

Validated Hypothesis: CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion

CSF Neurofilament Light Chain (NfL) in Neurodegeneration

Validated Hypothesis: Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD

Cerebrospinal Fluid (CSF) Biomarkers Overview

Validated Hypothesis: Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin

Validated Hypothesis: CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification

Cerebrospinal Fluid (CSF) Biomarkers in Neurodegeneration

HLCS Gene

CSF1R Inhibitors for Parkinson's Disease

Mitochondria-Lysosome Contact Sites (MLCS) in Neurodegeneration

Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypothesis in Parkinson's Disease

SORCS2 Gene

CSF-1R Inhibitors

CSNK1D - Casein Kinase 1 Delta

NPTX1 and NPTXR CSF Markers Predict Alzheimer's Disease Progression

Microglial Proteins in CSF Reveal AD Progression States

Pathway Diagram

Outgoing (40)

Incoming (8)

Targeting Hypotheses (30)

Mentioning Analyses (13)

Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Cau

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

What blood-brain barrier permeability changes serve as early biomarkers for neur

What blood-brain barrier permeability changes serve as early biomarkers for neur

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Which specific CSF molecular components are essential for maintaining disease-re

Proteomics Differential Expression in AD CSF and Brain Tissue

Metabolomic signatures of neurodegeneration: metabolic reprogramming in aging br

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What are the specific circulating factors in exercise-conditioned plasma that me

Neuroinflammation and microglial priming in early Alzheimer's Disease

Extracellular vesicle biomarkers for early AD detection

Experiments (5)

Related Papers (20)

Debates (17)

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream

What is the evidence that blood-brain barrier (BBB) permeability changes serve a

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

Formal debate: plasma GFAP separates causal from compensatory states in: Blood-b

Formal debate: tight-junction remodeling is the actionable driver in: Blood-brai

What blood-brain barrier permeability changes serve as early biomarkers for neur

What blood-brain barrier permeability changes serve as early biomarkers for neur

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Which specific CSF molecular components are essential for maintaining disease-re

Related Research

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion

Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin

CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degen

40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively

Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

Senescent Microglia Resolution via Maresins-Senolytics Combination

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlie

Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming

KCNQ2/3 (M-current) Channel Restoration Reactivates Theta Oscillation Dynamics

TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc