concept

NIX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NIX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

689Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NIX is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, associated with. Associated with AD, ALI, ALS. Connected to 312 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NIX
Key Genes/Proteins	MITOPHAGY, AMPK, MITOCHONDRIA, AUTOPHAGY, OVERVIEW
Related Diseases	Als, Cancer
Related Pathways	Mitophagy, Autophagy, oxidative stress response, autophagy pathway

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NIX["NIX"]
    NIX -->|"regulates"| mitophagy["mitophagy"]
    NIX -->|"interacts"| Alzheimer["Alzheimer"]
    NIX -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    NIX -->|"interacts"| Dementia["Dementia"]
    NIX -->|"interacts"| Cardiovascular["Cardiovascular"]
    NIX -->|"interacts"| Parkinson["Parkinson"]
    NIX -->|"degrades"| Aging["Aging"]
    NIX -->|"activates"| ALS["ALS"]
    NIX -->|"regulates"| MITOPHAGY["MITOPHAGY"]
    AMPK["AMPK"] -->|"inhibits"| NIX
    HIF1["HIF1"] -->|"regulates"| NIX
    BCL2L11["BCL2L11"] -->|"interacts"| NIX
    DNA["DNA"] -->|"interacts"| NIX
    BNIP3["BNIP3"] -->|"contributes to"| NIX
    MITOPHAGY -->|"inhibits"| NIX

Outgoing (353)

Target	Relation	Type	Str
Mitophagy	regulates	pathway	1.00
Als	regulates	disease	0.95
Programmed Mitophagy	mediates	process	0.90
programmed mitophagy	activates	process	0.90
programmed mitophagy	regulates	process	0.90
Autophagy	regulates	pathway	0.90
Cancer	regulates	disease	0.85
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
MITOCHONDRIA	associated_with	gene	0.80
AUTOPHAGY	regulates	gene	0.80
OVERVIEW	regulates	gene	0.80
MITOCHONDRIA	regulates	gene	0.80
CANCER	regulates	gene	0.80
BNIP3L	regulates	gene	0.80
PARKIN	regulates	gene	0.80
Ischemia	regulates	disease	0.75
MITOPHAGY	regulates	pathway	0.74
PARKIN	associated_with	gene	0.70
MITOCHONDRIA	activates	gene	0.70
BNIP3	regulates	gene	0.70
UBIQUITIN	regulates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
neural stem cells	regulates	cell_type	0.70
Alzheimer	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	degrades	disease	0.65
Cardiovascular	degrades	disease	0.65
ALS	activates	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Aging	regulates	disease	0.65
Tumor	implicated_in	disease	0.65
Crohn Disease	regulates	disease	0.65
Infection	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Als	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65

Incoming (336)

Source	Relation	Type	Str
MITOPHAGY	regulates	gene	1.00
BNIP3	regulates	gene	0.90
AMPK	inhibits	protein	0.82
P62	regulates	gene	0.80
HIF1	regulates	protein	0.74
BNIP3	contributes_to	gene	0.70
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.70
PINK1	regulates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
AMPK	regulates	gene	0.70
BCL2L11	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
MITOPHAGY	inhibits	gene	0.60
ROS	regulates	gene	0.60
LC3	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
AMBRA1	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
BNIP3	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NIX

Understanding Entity Pages

Summary

Wiki Pages (20)

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

mitophagy-defect

rapamycin-tauopathy

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

Mitophagy Pathway in Neurodegeneration

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

Mitochondria in Neurodegeneration

KDM3A Gene (JMJD1A)

pink1-parkin-mitophagy-pd-causal-chain

AMPK Signaling Pathway

Lysosomal Dysfunction in Progressive Supranuclear Palsy

Neural Circuits in Progressive Supranuclear Palsy

Mitophagy

Autophagy-Impaired Neurons