concept

NIX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NIX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

673Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NIX is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, associated with. Associated with AD, ALI, ALS. Connected to 312 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NIX
Key Genes/Proteins	ABCD3, ADORA2A, AGING, ALZHEIMER, ALZHEIMER DISEASE
Related Diseases	AD, Aging, ALI, Als, ALS
Related Pathways	Adaptive Immunity

Wiki Pages (1)

Knowledge base pages for this entity

BNIP3L — BCL2 Interacting Protein 3 Like (NIX)

gene · 738 words

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Pathway Diagram

graph TD
    NIX["NIX"]
    NIX -->|"regulates"| mitophagy["mitophagy"]
    NIX -->|"interacts"| Alzheimer["Alzheimer"]
    NIX -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    NIX -->|"interacts"| Dementia["Dementia"]
    NIX -->|"interacts"| Cardiovascular["Cardiovascular"]
    NIX -->|"interacts"| Parkinson["Parkinson"]
    NIX -->|"degrades"| Aging["Aging"]
    NIX -->|"activates"| ALS["ALS"]
    NIX -->|"regulates"| MITOPHAGY["MITOPHAGY"]
    AMPK["AMPK"] -->|"inhibits"| NIX
    HIF1["HIF1"] -->|"regulates"| NIX
    BCL2L11["BCL2L11"] -->|"interacts"| NIX
    DNA["DNA"] -->|"interacts"| NIX
    BNIP3["BNIP3"] -->|"contributes to"| NIX
    MITOPHAGY -->|"inhibits"| NIX

Outgoing (347)

Target	Relation	Type	Str
Mitophagy	regulates	pathway	1.00
Als	regulates	disease	0.95
programmed mitophagy	activates	process	0.90
Programmed Mitophagy	mediates	process	0.90
programmed mitophagy	regulates	process	0.90
Autophagy	regulates	pathway	0.90
Cancer	regulates	disease	0.85
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
MITOCHONDRIA	regulates	gene	0.80
OVERVIEW	regulates	gene	0.80
AUTOPHAGY	regulates	gene	0.80
BNIP3L	regulates	gene	0.80
PARKIN	regulates	gene	0.80
CANCER	regulates	gene	0.80
MITOCHONDRIA	associated_with	gene	0.80
Ischemia	regulates	disease	0.75
MITOPHAGY	regulates	pathway	0.74
ubiquitin-proteasome	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
BNIP3	regulates	gene	0.70
mitophagy	regulates	process	0.70
UBIQUITIN	regulates	gene	0.70
MITOCHONDRIA	activates	gene	0.70
PARKIN	associated_with	gene	0.70
neural stem cells	regulates	cell_type	0.70
Alzheimer	interacts_with	disease	0.65
Als	activates	disease	0.65
Infection	activates	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ischemia	associated_with	disease	0.65
ALS	activates	disease	0.65
Parkinson	interacts_with	disease	0.65
Insulin Resistance	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Dementia	interacts_with	disease	0.65
Tumor	implicated_in	disease	0.65
Cardiovascular	degrades	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Aging	degrades	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Obesity	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Cardiovascular	regulates	disease	0.65

Incoming (326)

Source	Relation	Type	Str
MITOPHAGY	regulates	gene	1.00
BNIP3	regulates	gene	0.90
AMPK	inhibits	protein	0.82
P62	regulates	gene	0.80
HIF1	regulates	protein	0.74
BNIP3	associated_with	gene	0.70
AMPK	regulates	gene	0.70
PINK1	regulates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.60
P62	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
NLRP3	associated_with	gene	0.60
NR4A1	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
TNF	associated_with	gene	0.60
RIPK2	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
ATG	associated_with	gene	0.60
MFF	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
TUFM	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
TRAF2	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
IFN	associated_with	gene	0.60
IKBKE	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
MAVS	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
MITOCHONDRIA	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NIX in their description or question text

No additional research found