Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NLRX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NLRX1 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, protects against. Associated with Als, Autoimmune, Inflammation. Connected to 28 entities in the SciDEX knowledge graph.
| Gene Symbol | NLRX1 |
| Aliases | NOD5, FLYWCH1 |
| Chromosome | 6q16.1 |
| Protein Type | Receptor |
| Function | Upon detection of viral RNA in the cytosol, NLRX1 interacts with MAVS (Mitochondrial Antiviral Signaling Protein) to enhance downstream NF-κB and IRF activation, leading to production of type I interf |
| Primary Expression | multiple tissues, including the brain, where it is found in neurons, astrocytes, and [microglia](/cell-ty |
| Molecular Weight | 103 kDa |
| Amino Acids | 977 aa |
| Pathways | NF-κB |
| UniProt ID | Q9NWV8 |
| NCBI Gene ID | 79671 |
| Ensembl ID | ENSG00000170873 |
| GeneCards | NLRX1 |
| Human Protein Atlas | NLRX1 |
| Official Name | NLR Family Member X1 |
| Associated Diseases | Parkinson |
| Interactions | MTOR, OPTN, PINK1, PRKN, PTEN, TIMM23 |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NLRX1["<b>NLRX1</b>"]
Stroke{"Stroke"}
NLRX1 -->|"activates"| Stroke
Ischemia{"Ischemia"}
NLRX1 -->|"regulates"| Ischemia
Ms{"Ms"}
NLRX1 -->|"activates"| Ms
Mtor(["Mtor"])
NLRX1 -->|"activates"| Mtor
Phagocytosis(["Phagocytosis"])
NLRX1 -->|"activates"| Phagocytosis
MTOR["MTOR"]
NLRX1 -->|"activates"| MTOR
AND["AND"]
NLRX1 -->|"activates"| AND
neurodegeneration["neurodegeneration"]
NLRX1 -->|"implicated in"| neurodegeneration
TFEB["TFEB"]
TFEB -->|"activates"| NLRX1
MTOR -->|"activates"| NLRX1
STROKE["STROKE"]
STROKE -->|"activates"| NLRX1
NEUROTOXICITY["NEUROTOXICITY"]
NEUROTOXICITY -->|"activates"| NLRX1
PHAGOCYTOSIS["PHAGOCYTOSIS"]
PHAGOCYTOSIS -->|"activates"| NLRX1
style NLRX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Mitophagy | regulates | pathway | 0.70 |
| microglia | expressed_in | cell_type | 0.70 |
| Stroke | activates | disease | 0.65 |
| Ischemia | regulates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Autoimmune | protects_against | disease | 0.65 |
| Multiple Sclerosis | activates | disease | 0.65 |
| Neurodegeneration | protects_against | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Als | activates | disease | 0.65 |
| MTOR | activates | gene | 0.60 |
| PARKIN | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| OPTN | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| TIMM23 | activates | gene | 0.60 |
| TMEM59 | activates | gene | 0.60 |
| TOMM20 | activates | gene | 0.60 |
| STING | regulates | gene | 0.60 |
| neurodegeneration | protects_against | disease | 0.60 |
| neuroinflammation | regulates | disease | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| TFEB | activates | gene | 0.60 |
| TFEB | inhibits | gene | 0.60 |
| stroke | regulates | disease | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Phagocytosis | activates | pathway | 0.60 |
| NEURODEGENERATION | protects_against | gene | 0.60 |
| MITOCHONDRIA | interacts_with | gene | 0.60 |
| Parkinson | associated_with | disease | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| necroptosis | participates_in | pathway | 0.60 |
| OPTN | co_expressed_with | gene | 0.50 |
| PINK1 | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MITOPHAGY | regulates | gene | 0.70 |
| TFEB | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| PINK1 | regulates | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| ABP | activates | gene | 0.60 |
| ATG16L1 | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| CALCOCO2 | activates | gene | 0.60 |
| CASP3 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| HTT | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MFF | activates | gene | 0.60 |
| NBR1 | activates | gene | 0.60 |
| NDP52 | activates | gene | 0.60 |
| MLKL | activates | gene | 0.60 |
| STROKE | activates | gene | 0.60 |
| NEUROTOXICITY | activates | gene | 0.60 |
| PHAGOCYTOSIS | activates | gene | 0.60 |
| TSLP | regulates | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
| EXERCISE | regulates | gene | 0.60 |
| DMSO | activates | gene | 0.60 |
| GFP | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| NLR | activates | gene | 0.60 |
| NLR | regulates | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| NDP52 | co_expressed_with | gene | 0.50 |
| NLR | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||