protein

NLRX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections
0Hypotheses
0Analyses
43Outgoing
32Incoming

Summary

NLRX1 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, protects against. Associated with Als, Autoimmune, Inflammation. Connected to 28 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolNLRX1
AliasesNOD5, FLYWCH1
Chromosome6q16.1
Protein TypeReceptor
FunctionUpon detection of viral RNA in the cytosol, NLRX1 interacts with MAVS (Mitochondrial Antiviral Signaling Protein) to enhance downstream NF-κB and IRF activation, leading to production of type I interf
Primary Expressionmultiple tissues, including the brain, where it is found in neurons, astrocytes, and [microglia](/cell-ty
Molecular Weight103 kDa
Amino Acids977 aa
PathwaysNF-κB
UniProt IDQ9NWV8
NCBI Gene ID79671
Ensembl IDENSG00000170873
GeneCardsNLRX1
Human Protein AtlasNLRX1
Official NameNLR Family Member X1
Associated DiseasesParkinson
InteractionsMTOR, OPTN, PINK1, PRKN, PTEN, TIMM23
KG Connections75 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NLRX1 — AlphaFold Q9NWV8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

NLR Family Member X1

gene · 997 words

NLRC3 — NLR Family CARD Domain Containing 3

gene · 1373 words

NLRX1 Protein

protein · 902 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    NLRX1["<b>NLRX1</b>"]
    Stroke{"Stroke"}
    NLRX1 -->|"activates"| Stroke
    Ischemia{"Ischemia"}
    NLRX1 -->|"regulates"| Ischemia
    Ms{"Ms"}
    NLRX1 -->|"activates"| Ms
    Mtor(["Mtor"])
    NLRX1 -->|"activates"| Mtor
    Phagocytosis(["Phagocytosis"])
    NLRX1 -->|"activates"| Phagocytosis
    MTOR["MTOR"]
    NLRX1 -->|"activates"| MTOR
    AND["AND"]
    NLRX1 -->|"activates"| AND
    neurodegeneration["neurodegeneration"]
    NLRX1 -->|"implicated in"| neurodegeneration
    TFEB["TFEB"]
    TFEB -->|"activates"| NLRX1
    MTOR -->|"activates"| NLRX1
    STROKE["STROKE"]
    STROKE -->|"activates"| NLRX1
    NEUROTOXICITY["NEUROTOXICITY"]
    NEUROTOXICITY -->|"activates"| NLRX1
    PHAGOCYTOSIS["PHAGOCYTOSIS"]
    PHAGOCYTOSIS -->|"activates"| NLRX1
    style NLRX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (43)

TargetRelationTypeStr
Mitophagyregulatespathway0.70
microgliaexpressed_incell_type0.70
Strokeactivatesdisease0.65
Ischemiaregulatesdisease0.65
Msactivatesdisease0.65

Incoming (32)

SourceRelationTypeStr
MITOPHAGYregulatesgene0.70
TFEBactivatesgene0.60
MTORactivatesgene0.60
PINK1regulatesgene0.60
PINK1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found