concept

NOX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

200Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

NOX is a concept in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Cancer. Connected to 120 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameNOX
Key Genes/ProteinsROS
Related DiseasesAls, Inflammation, Lymphoma, Ms, Cancer
Related PathwaysAutophagy, Immune Response, oxidative stress response

Wiki Pages (20)

Knowledge base pages for this entity

RNA Therapeutics for Neurodegeneration Investment Landscape

investment · 3955 words

Hydrogen Peroxide Metabolism Pathway

mechanism · 3544 words

Neuroinflammation in Parkinson's Disease

mechanism · 3418 words

Oxidative Stress in Neurodegeneration

mechanism · 3216 words

Reactive Oxygen Species (ROS) Pathway

mechanism · 3211 words

Pathway Diagram

graph TD
    NOX["NOX"]
    NOX -->|"activates"| Als["Als"]
    NOX -->|"activates"| Ms["Ms"]
    NOX -->|"activates"| Cancer["Cancer"]
    NOX -->|"activates"| Cardiac["Cardiac"]
    NOX -->|"activates"| Inflammation["Inflammation"]
    NOX -->|"activates"| ALS["ALS"]
    NOX -->|"produces"| ROS["ROS"]
    NOX -->|"activates"| POR["POR"]
    NOX -->|"regulates"| Ferroptosis["Ferroptosis"]
    LPCAT3["LPCAT3"] -->|"activates"| NOX
    ACSL4["ACSL4"] -->|"activates"| NOX
    G6PD["G6PD"] -->|"activates"| NOX
    SMAD3["SMAD3"] -->|"regulates"| NOX
    CDH1["CDH1"] -->|"activates"| NOX
    LC3B["LC3B"] -->|"activates"| NOX
    NOX4["NOX4"] -->|"activates"| NOX
    P62["P62"] -->|"activates"| NOX

Outgoing (114)

TargetRelationTypeStr
Alsactivatesdisease0.75
Autophagyactivatespathway0.70
Immune Responseactivatespathway0.70
oxidative stress responseparticipates_inpathway0.70
ROSactivatesgene0.70

Incoming (86)

SourceRelationTypeStr
PI3Kassociated_withgene0.60
MYD88associated_withgene0.60
MTORassociated_withgene0.60
NRF2associated_withgene0.60
AKTassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found