protein

APOER2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOER2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

162Connections

0Hypotheses

0Analyses

50Outgoing

49Incoming

0Experiments

0Debates

Summary

Page for ApoER2 Protein

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🔬 Protein Info

Gene Symbol	APOER2
Molecular Weight	110 kDa
Amino Acids	963 aa
Pathways	Cerebrovascular, Dendritic Spine, Synaptic Plasticity, Wnt, Lipid Metabolism
GeneCards	APOER2
Human Protein Atlas	APOER2
Associated Diseases	Aging, Als, Atherosclerosis, Cancer, Cardiovascular
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE, APOE3
KG Connections	150 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    APOER2(["APOER2"])
    RLN["RLN"]
    Atherosclerosis["Atherosclerosis"]
    Ms["Ms"]
    Als["Als"]
    Alzheimer["Alzheimer"]
    ALS["ALS"]
    Autism["Autism"]
    Depression["Depression"]
    Schizophrenia["Schizophrenia"]
    Bipolar["Bipolar"]
    Epilepsy["Epilepsy"]
    Cardiovascular["Cardiovascular"]
    Cancer["Cancer"]
    Neurodegeneration["Neurodegeneration"]
    Aging["Aging"]
    Hypertension["Hypertension"]
    Stroke["Stroke"]
    APOER2 -->|"binds"| RLN
    APOER2 -->|"increases_risk"| Atherosclerosis
    APOER2 -.->|"inhibits"| Ms
    APOER2 -.->|"inhibits"| Als
    APOER2 -.->|"inhibits"| Alzheimer
    APOER2 -.->|"inhibits"| ALS
    APOER2 -->|"regulates"| Autism
    APOER2 -->|"regulates"| Alzheimer
    APOER2 -->|"regulates"| Depression
    APOER2 -->|"regulates"| Schizophrenia
    APOER2 -->|"regulates"| Bipolar
    APOER2 -->|"regulates"| Epilepsy
    APOER2 -.-|"associated"| Cardiovascular
    APOER2 -.-|"associated"| Cancer
    APOER2 -.-|"associated"| Neurodegeneration
    APOER2 -.-|"associated"| Aging
    APOER2 -.-|"associated"| Atherosclerosis
    APOER2 -.-|"associated"| Hypertension
    APOER2 -.-|"associated"| Stroke
    APOER2 -.-|"associated"| ALS
    style APOER2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (113)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	involved_in	disease	0.95
Reelin Signaling Pathway	part_of	pathway	0.90
Nmda Receptor	activates	receptor	0.90
FYN	activates	protein	0.85
Atherosclerosis	increases_risk	disease	0.80
Alzheimer	regulates	disease	0.65
Depression	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Bipolar	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Dementia	activates	disease	0.65
Heart Failure	associated_with	disease	0.65
Epilepsy	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Depression	activates	disease	0.65
Als	activates	disease	0.65
Autism	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
ALZHEIMER	activates	gene	0.60
TAU	activates	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
VEGF	activates	gene	0.60
GFAP	activates	gene	0.60
Endothelial	activates	cell_type	0.60
Rb	inhibits	protein	0.60
Ras	inhibits	protein	0.60
VGLUT1	activates	gene	0.60
APOE3	activates	gene	0.60
Aβ	activates	protein	0.60
App	associated_with	protein	0.60
neurons	expressed_in	cell_type	0.60
ALZHEIMER	regulates	gene	0.60
EPILEPSY	regulates	gene	0.60
SRC	associated_with	gene	0.60
JUN	regulates	gene	0.60
DAB1	associated_with	gene	0.60
Neuron	regulates	cell_type	0.60

Incoming (49)

Source	Relation	Type	Str
RELN	binds	protein	0.95
Reelin	binds_to	protein	0.90
APOE	binds	gene	0.90
REELIN	binds	protein	0.90
APP	binds	gene	0.85
Oligomeric Amyloid Beta	inhibits	compound	0.85
APOE	binds	gene	0.80
APOE4	interacts_with	gene	0.70
APOE3	activates	gene	0.60
GFAP	activates	gene	0.60
AMYLOID	activates	gene	0.60
CD2AP	activates	gene	0.60
AND	activates	gene	0.60
NEURON	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
REST	activates	gene	0.60
REELIN	activates	gene	0.60
EPILEPSY	regulates	gene	0.60
SRC	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEPRESSION	regulates	gene	0.60
DAB1	associated_with	gene	0.60
JUN	regulates	gene	0.60
AND	associated_with	gene	0.60
FYN	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
REELIN	associated_with	gene	0.60
LRP8	associated_with	gene	0.60
LDL	associated_with	gene	0.60
LRP2	associated_with	gene	0.60
PAH	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
WNT	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AGING	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
VEGF	activates	gene	0.60
VGLUT1	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
DEMENTIA	activates	gene	0.60
RELN	interacts_with	gene	0.50
LRP1	associated_with	gene	0.50
LDLR	associated_with	gene	0.50
LRP4	associated_with	gene	0.50
LRP5	associated_with	gene	0.50
LRP1B	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity