protein

REELIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REELIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

341Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Comprehensive page on Reelin - structure, function, role in neuronal migration, synaptic plasticity, and Alzheimer's disease

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🔬 Protein Info

Gene Symbol	RELN
Aliases	Comprehensive page on Reelin
Chromosome	7q22.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	388 kDa
Amino Acids	460 aa
Pathways	Dendritic Spine
UniProt ID	P78536
NCBI Gene ID	5649
GeneCards	RELN
Human Protein Atlas	RELN
Approach	Status
Recombinant Reelin protein	Research
Reelin-enhancing compounds	Preclinical
Gene therapy	Preclinical
Associated Diseases	ALS, AUTISM, Aging, Alzheimer, Alzheimer'S Disease
Interactions	CD2AP, REST, MTOR, CCR5, CCL5, CXCR4
KG Connections	322 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: REELIN — AlphaFold P78536 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    REELIN["REELIN"] -->|"causes"| ALS["ALS"]
    REELIN["REELIN"] -.->|"inhibits"| ALS_1["ALS"]
    REELIN["REELIN"] -.->|"inhibits"| Alzheimer["Alzheimer"]
    REELIN["REELIN"] -->|"regulates"| ALS_2["ALS"]
    REELIN["REELIN"] -->|"associated"| Alzheimer_3["Alzheimer"]
    REELIN["REELIN"] -->|"associated"| Autism["Autism"]
    CDK5["CDK5"] -->|"causes"| REELIN["REELIN"]
    AXON["AXON"] -->|"causes"| REELIN["REELIN"]
    LIS1["LIS1"] -->|"causes"| REELIN["REELIN"]
    NEURON["NEURON"] -->|"causes"| REELIN["REELIN"]
    style REELIN fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (228)

Target	Relation	Type	Str
NEURONAL MIGRATION	regulates	entity	0.90
dendritic growth and branching	regulates	process	0.90
dendritic spine formation	regulates	process	0.90
synaptogenesis	regulates	process	0.90
Apoer2	binds	receptor	0.90
synaptic plasticity	regulates	process	0.90
Nmda Receptor	activates	receptor	0.85
lissencephaly	implicated_in	disease	0.80
schizophrenia	implicated_in	disease	0.80
bipolar disorder	implicated_in	disease	0.80
mental retardation	implicated_in	disease	0.80
AUTISM	implicated_in	disease	0.80
DEPRESSION	implicated_in	disease	0.80
Alzheimer's disease	implicated_in	disease	0.80
Addiction	therapeutic_target	disease	0.65
ALS	causes	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Alzheimer	protects_against	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	contributes_to	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Als	regulates	disease	0.65
Als	causes	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Depression	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
ALS	activates	disease	0.65
Dementia	activates	disease	0.65

Incoming (113)

Source	Relation	Type	Str
DAB1	interacts_with	entity	0.85
APP	associated_with	gene	0.75
CD2AP	protects_against	entity	0.60
APOE	therapeutic_target	entity	0.60
LISSENCEPHALY	associated_with	entity	0.60
LISSENCEPHALY	mediates	entity	0.60
AUTISM	mediates	entity	0.60
DEPRESSION	mediates	entity	0.60
EPILEPSY	mediates	entity	0.60
CDK5	causes	gene	0.60
LIS1	causes	gene	0.60
DCX	causes	gene	0.60
DYNEIN	causes	gene	0.60
PAFAH1B1	causes	gene	0.60
DAB1	causes	gene	0.60
REST	activates	gene	0.60
CD2AP	activates	gene	0.60
JUN	protects_against	gene	0.60
APOE	associated_with	gene	0.60
RELN	protects_against	gene	0.60
FYN	associated_with	gene	0.60
JUN	regulates	gene	0.60
SRC	associated_with	gene	0.60
DAB1	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
LRP4	associated_with	gene	0.60
LRP2	associated_with	gene	0.60
PAH	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
LRP8	associated_with	gene	0.60
LRP5	associated_with	gene	0.60
TAU	therapeutic_target	gene	0.60
PSD95	activates	gene	0.60
CCR5	activates	gene	0.60
CXCR4	activates	gene	0.60
MTOR	activates	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
PVALB	expressed_in	gene	0.60
DAB1	activates	gene	0.60
GAIN	activates	gene	0.60
REST	protects_against	gene	0.60
LRP1B	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
HO1	associated_with	gene	0.60
NRF2	therapeutic_target	gene	0.60
PKC	therapeutic_target	gene	0.60
BDNF	associated_with	gene	0.60
STAT6	associated_with	gene	0.60
APOE	protects_against	gene	0.60
APP	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Reelin-Mediated Cytoskeletal Stabilization Protocol	0.448	neurodegeneration	Selective vulnerability of entorhinal co

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction. [PMID:39892386]	Vandal M, Institoris A, Reveret L, Korin	Neuron	2025	1
Protective genetic variants against Alzheimer's disease. [PMID:40409316]	Marino C, Malotaux V, Giudicessi A, Agui	Lancet Neurol	2025	1
Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional [PMID:39232006]	Serafin DS, Harris NR, Bálint L, Douglas	Nat Commun	2024	1
Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Devel [PMID:32604886]	Jossin Y	Biomolecules	2020	1
Neuronal migration. [PMID:11429281]	Lambert de Rouvroit C, Goffinet AM	Mech Dev	2001	1
Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, a [PMID:41858499]	["Barger S", "Moerman-Herzog A"]	Frontiers in molecular neurosc	2026	0
The Potential Molecular Mechanisms and Key Genes of Early Deterioration of Paren [PMID:41863408]	["Cen G", "Li J", "Wang J", "Chen Y", "L	Current neurovascular research	2026	0
RELN biallelic variant as a candidate risk factor in a consanguineous Pakistani [PMID:41785923]	["Hashmi A", "Harripaul R", "Muhammad T"	Journal of affective disorders	2026	0
Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Fo [PMID:41677619]	["Smith M", "Natarajan E", "Lizama-Valen	Cells	2026	0
Migration of dI5 Reelin-Lmx1b-Zfhx3 and Disabled-1-Lmx1b-Zfhx3 neurons contribut [PMID:41890024]	["Yvone G", "Chavez-Martinez C", "Mekonn	bioRxiv : the preprint server	2026	0
Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler [PMID:41844513]	["Simanaviciute U", "Cetin A", "Guy J",	Genes, brain, and behavior	2026	0
Reln haploinsufficiency enhances fentanyl-induced locomotion and striatal activi [PMID:41890027]	["Litif C", "Libster A", "Desfor S", "Hu	bioRxiv : the preprint server	2026	0
Immunoglobulin allotypes and [PMID:41848375]	["Pandey J", "Namboodiri A", "Nietert P"	Journal of Alzheimer's disease	2026	0
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052]	["Burdman G", "Akkaoui J", "Colon N", "P	Neurology international	2026	0
Genetic or therapeutic disruption of the Reelin/Apoer2 signaling pathway improve [PMID:40073057]	["Calvier L", "Wasser C", "Solow E", "Wu	Proceedings of the National Ac	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073]	Castanho I, Naderi Yeganeh P, Boix CA, M	Molecular neurodegeneration	2025	0
Glutamatergic argonaute2 promotes the formation of the neurovascular unit in mic [PMID:39999211]	Sona C, Yeh YT, Li Y, Liu X, Ghosh A, Hi	Science signaling	2025	0
APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodege [PMID:40307424]	["Vanherle S", "Janssen A", "Guti\u00e9r	Molecular psychiatry	2025	0
Protective Genes Against Alzheimer's Disease: Case Review and Therapeutic Implic [PMID:40321438]	Hossain N, Jeong Y	Dementia and neurocognitive di	2025	0
Biomolecular Aspects of Reelin in Neurodegenerative Disorders: An Old Candidate [PMID:40806482]	Balzamino BO, Biamonte F, Micera A	International journal of molec	2025	0

REELIN

Understanding Entity Pages

Summary

Wiki Pages (21)

Reelin Protein

Growth Factor Therapies

gabaergic-dysfunction

CSF Neurofilament Light Chain (NfL) in Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

Thyroid Hormone Signaling Pathway in Neurodegeneration

Gut-Microbiome-Neurodegeneration Axis

Miller-Dieker Syndrome

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

Kyoto University

ubiquitin-proteasome-dysfunction-neurodegeneration

cGMP Signaling Pathway in Neurodegeneration

Lipid Metabolism Dysregulation in Neurodegeneration

Amyloid Precursor Protein (APP)

Iron Homeostasis Dysregulation in Neurodegeneration

university-of-rochester

Brazilian Neurodegeneration Biotech Companies

Liver-Brain Neurodegeneration Axis