Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB27A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RAB27A |
| Aliases | Ras-Related Protein Rab-27A |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | RAB27A regulates multiple trafficking pathways: |
| Mechanism of Action | RAB27A inhibitors would block GTP binding or GTPase activity, preventing the recruitment of effector proteins required for vesicular trafficking and exosome biogenesis. This would reduce the release of extracellular vesicles and potentially modulate intercellular communication in disease states involving excessive exosome-mediated signaling or pathological cargo transfer. |
| Druggability | Low (0.35) |
| Clinical Stage | Phase II |
| Molecular Weight | 25 kDa |
| Pathways | Mitochondrial dynamics / bioenergetics, Multivesicular Endosome Docking |
| UniProt ID | H3BS49 |
| GeneCards | RAB27A |
| Human Protein Atlas | RAB27A |
| PD Feature | RAB27A Relationship |
| [Alpha-synuclein](/proteins/alpha-synuclein) pathology | RAB27A in Lewy bodies |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | Nexinhib20 |
| Interactions | LATS2, COL4A1, SQSTM1, SERPINE1, LAMP1, ARSA |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | RAB27A-dependent extracellular vesicle engineering |
| KG Connections | 195 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB27A["<b>RAB27A</b>"]
Ms{"Ms"}
RAB27A -->|"activates"| Ms
Als{"Als"}
RAB27A -->|"inhibits"| Als
Cancer{"Cancer"}
RAB27A -->|"activates"| Cancer
Cardiovascular{"Cardiovascular"}
RAB27A -->|"activates"| Cardiovascular
Inflammation{"Inflammation"}
RAB27A -->|"activates"| Inflammation
Tumor{"Tumor"}
RAB27A -->|"activates"| Tumor
Carcinoma{"Carcinoma"}
RAB27A -->|"inhibits"| Carcinoma
RAB27A -->|"inhibits"| Ms
RAB27A -->|"inhibits"| Cancer
RAB27A -->|"inhibits"| Tumor
ALS{"ALS"}
RAB27A -->|"inhibits"| ALS
RAB27B["RAB27B"]
RAB27A -->|"regulates"| RAB27B
h_250b34ab["h-250b34ab"]
h_250b34ab -->|"therapeutic target"| RAB27A
h_250b34ab -->|"targets"| RAB27A
JUN["JUN"]
JUN -->|"activates"| RAB27A
LATS2["LATS2"]
LATS2 -->|"activates"| RAB27A
YAP["YAP"]
YAP -->|"activates"| RAB27A
MICRORNAS["MICRORNAS"]
MICRORNAS -->|"activates"| RAB27A
CDKN2A["CDKN2A"]
CDKN2A -->|"inhibits"| RAB27A
TLR4["TLR4"]
TLR4 -->|"inhibits"| RAB27A
CANCER["CANCER"]
CANCER -->|"inhibits"| RAB27A
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"inhibits"| RAB27A
TNC["TNC"]
TNC -->|"inhibits"| RAB27A
NTRK2["NTRK2"]
NTRK2 -->|"inhibits"| RAB27A
style RAB27A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Exosome Secretion | promotes | process | 0.95 |
| Multivesicular Endosome Docking | involved_in | process | 0.90 |
| multivesicular endosome docking | regulates | process | 0.90 |
| Multivesicular Endosome Size | regulates | phenotype | 0.85 |
| SYTL4 | interacts_with | protein | 0.85 |
| multivesicular endosome size | modulates | phenotype | 0.85 |
| RAB27B | interacts_with | protein | 0.80 |
| RAB27A_protein | encodes | protein | 0.80 |
| Als | inhibits | disease | 0.75 |
| Ms | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Cardiovascular | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Melanoma | inhibits | disease | 0.65 |
| Senescence | activates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| microglia | expressed_in | cell_type | 0.65 |
| RAB27B | regulates | gene | 0.60 |
| LATS2 | activates | gene | 0.60 |
| COL4A1 | inhibits | gene | 0.60 |
| neurodegeneration | implicated_in | disease | 0.60 |
| SQSTM1 | inhibits | gene | 0.60 |
| SERPINE1 | inhibits | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| ARSA | activates | gene | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| CXCL12 | inhibits | gene | 0.60 |
| CTSD | inhibits | gene | 0.60 |
| RAB27B | associated_with | entity | 0.60 |
| RAB27B | upregulates | entity | 0.60 |
| RAB27B | inhibits | entity | 0.60 |
| JUN | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| MICRORNAS | activates | gene | 0.60 |
| YAP | activates | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| Mapk | inhibits | pathway | 0.60 |
| EXOSOMES | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-250b34ab | targets_gene | hypothesis | 0.90 |
| h-d78123d1 | targets_gene | hypothesis | 0.90 |
| ARRB1 | activates | protein | 0.85 |
| h-250b34ab | targets | hypothesis | 0.80 |
| JUN | activates | gene | 0.60 |
| LATS2 | activates | gene | 0.60 |
| CDKN2A | inhibits | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TNC | inhibits | gene | 0.60 |
| NTRK2 | inhibits | gene | 0.60 |
| PAK1 | associated_with | gene | 0.60 |
| WNT7A | inhibits | gene | 0.60 |
| LZTS1 | inhibits | gene | 0.60 |
| DCC | inhibits | gene | 0.60 |
| KCNK2 | inhibits | gene | 0.60 |
| CD44 | inhibits | gene | 0.60 |
| FGF10 | inhibits | gene | 0.60 |
| DLC1 | inhibits | gene | 0.60 |
| KCNH1 | inhibits | gene | 0.60 |
| NCAM1 | inhibits | gene | 0.60 |
| RGS1 | inhibits | gene | 0.60 |
| RAB27B | regulates | gene | 0.60 |
| P62 | inhibits | gene | 0.60 |
| CCL3 | inhibits | gene | 0.60 |
| RAB8A | regulates | gene | 0.60 |
| RAB11A | regulates | gene | 0.60 |
| DNAJC5 | regulates | gene | 0.60 |
| ATG7 | regulates | gene | 0.60 |
| VAMP7 | regulates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| RAB27B | transports | gene | 0.60 |
| YAP | activates | gene | 0.60 |
| MICRORNAS | activates | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| ENDOSOMES | activates | gene | 0.60 |
| EXOSOMES | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| ATG | regulates | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| LYSOSOME | inhibits | gene | 0.60 |
| CANCER | activates | entity | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | regulates | gene | 0.60 |
| ALS | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| EXOSOMES | inhibits | gene | 0.60 |
| RNA | inhibits | gene | 0.60 |
| RNA | transports | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| RAB27A-dependent extracellular vesicle engineering for mitoc | 0.414 | neurodegeneration | Mitochondrial transfer between astrocyte |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.450
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Tumour extracellular vesicles and particles induce liver metabolic dysfunction. [PMID:37225988] | Wang G, Li J, Bojmar L, Chen H, Li Z, To | Nature | 2023 | 1 |
| Extracellular vesicles in fatty liver promote a metastatic tumor microenvironmen [PMID:37172577] | Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang | Cell Metab | 2023 | 1 |
| Rab27a and Rab27b control different steps of the exosome secretion pathway. [PMID:19966785] | Ostrowski M, Carmo NB, Krumeich S, Fange | Nat Cell Biol | 2010 | 1 |
| EVs-Mediated Intracardiac Crosstalk Mitigates Doxorubicin-Induced Cardiotoxicity [PMID:41948821] | Wang H, Chen Y, Wang T, Ye X, Zhang X et | Circ Res | 2026 | 0 |
| Autophagic extracellular vesicles: a distinct secretory route linking autophagy [PMID:41958120] | Wei H, Fu Y | Autophagy | 2026 | 0 |
| Case Report: Late-onset primary hemophagocytic lymphohistiocytosis leading to th [PMID:40852732] | ["Rausch J", "Herold S", "Liebh\u00e4use | Frontiers in immunology | 2025 | 0 |
| Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure. [PMID:38847080] | Mallaredy V, Roy R, Cheng Z, Thej C, Ben | Circulation research | 2024 | 0 |
| Interruption of p38 [PMID:38481807] | ["Kim S", "Lee J", "Jung J", "Kim G", "Y | International journal of biolo | 2024 | 0 |
| Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to [PMID:35849032] | Liu X, Tan S, Liu H, Jiang J, Wang X, Li | Hepatology (Baltimore, Md.) | 2023 | 0 |
| Autophagy and exosomes coordinately mediate quercetin's protective effects on al [PMID:36965782] | ["Chen H", "Liu J", "Peng S", "Yang G", | The Journal of nutritional bio | 2023 | 0 |
| Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast ac [PMID:37357686] | Huang Q, Sun Y, Peng L, Sun J, Sha Z, Li | Journal of extracellular vesic | 2023 | 0 |
| Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Ra [PMID:35701443] | ["Pattanayak R", "Underwood R", "Crowley | Scientific reports | 2022 | 0 |
| Capturing membrane trafficking events during 3D angiogenic development in vitro. [PMID:34415654] | ["Francis C", "Kushner E"] | Microcirculation (New York, N. | 2022 | 0 |
| In vivo Roles of Rab27 and Its Effectors in Exocytosis. [PMID:34483204] | ["Izumi T"] | Cell structure and function | 2021 | 0 |
| Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. [PMID:29590046] | ["Zhao L", "Zhang F", "Ding X", "Wu G", | Science (New York, N.Y.) | 2018 | 0 |
| White matter microstructure in transsexuals and controls investigated by diffusi [PMID:25392513] | ["Kranz G", "Hahn A", "Kaufmann U", "K\u | The Journal of neuroscience : | 2014 | 0 |
| Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interacti [PMID:23201972] | ["Klengel T", "Mehta D", "Anacker C", "R | Nature neuroscience | 2013 | 0 |