protein

RAB27A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB27A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

195Connections
1Hypotheses
2Analyses
50Outgoing
50Incoming

Summary

Page for RAB27A Protein (Ras-Related Protein Rab-27A)

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🔬 Protein Info
Gene SymbolRAB27A
AliasesRas-Related Protein Rab-27A
Protein TypeSignaling Protein
Target ClassSignaling Protein
FunctionRAB27A regulates multiple trafficking pathways:
Mechanism of ActionRAB27A inhibitors would block GTP binding or GTPase activity, preventing the recruitment of effector proteins required for vesicular trafficking and exosome biogenesis. This would reduce the release of extracellular vesicles and potentially modulate intercellular communication in disease states involving excessive exosome-mediated signaling or pathological cargo transfer.
DruggabilityLow (0.35)
Clinical StagePhase II
Molecular Weight25 kDa
PathwaysMitochondrial dynamics / bioenergetics, Multivesicular Endosome Docking
UniProt IDH3BS49
GeneCardsRAB27A
Human Protein AtlasRAB27A
PD FeatureRAB27A Relationship
[Alpha-synuclein](/proteins/alpha-synuclein) pathologyRAB27A in Lewy bodies
Associated Diseasesneurodegeneration
Known Drugs/CompoundsNexinhib20
InteractionsLATS2, COL4A1, SQSTM1, SERPINE1, LAMP1, ARSA
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesRAB27A-dependent extracellular vesicle engineering
KG Connections195 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: RAB27A — AlphaFold H3BS49 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RAB27A Gene

gene · 793 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Astrocytes

cell · 3974 words

Exosome and Extracellular Vesicle Brain Delivery

therapeutic · 3732 words

Mitochondria in Neurodegeneration

mechanism · 3404 words

Mitochondrial Support Strategies for CBS/PSP

therapeutic · 3359 words

Pathway Diagram

graph TD
    RAB27A["<b>RAB27A</b>"]
    Ms{"Ms"}
    RAB27A -->|"activates"| Ms
    Als{"Als"}
    RAB27A -->|"inhibits"| Als
    Cancer{"Cancer"}
    RAB27A -->|"activates"| Cancer
    Cardiovascular{"Cardiovascular"}
    RAB27A -->|"activates"| Cardiovascular
    Inflammation{"Inflammation"}
    RAB27A -->|"activates"| Inflammation
    Tumor{"Tumor"}
    RAB27A -->|"activates"| Tumor
    Carcinoma{"Carcinoma"}
    RAB27A -->|"inhibits"| Carcinoma
    RAB27A -->|"inhibits"| Ms
    RAB27A -->|"inhibits"| Cancer
    RAB27A -->|"inhibits"| Tumor
    ALS{"ALS"}
    RAB27A -->|"inhibits"| ALS
    RAB27B["RAB27B"]
    RAB27A -->|"regulates"| RAB27B
    h_250b34ab["h-250b34ab"]
    h_250b34ab -->|"therapeutic target"| RAB27A
    h_250b34ab -->|"targets"| RAB27A
    JUN["JUN"]
    JUN -->|"activates"| RAB27A
    LATS2["LATS2"]
    LATS2 -->|"activates"| RAB27A
    YAP["YAP"]
    YAP -->|"activates"| RAB27A
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"activates"| RAB27A
    CDKN2A["CDKN2A"]
    CDKN2A -->|"inhibits"| RAB27A
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| RAB27A
    CANCER["CANCER"]
    CANCER -->|"inhibits"| RAB27A
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| RAB27A
    TNC["TNC"]
    TNC -->|"inhibits"| RAB27A
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| RAB27A
    style RAB27A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (110)

TargetRelationTypeStr
Exosome Secretionpromotesprocess0.95
Multivesicular Endosome Dockinginvolved_inprocess0.90
multivesicular endosome dockingregulatesprocess0.90
Multivesicular Endosome Sizeregulatesphenotype0.85
SYTL4interacts_withprotein0.85

Incoming (85)

SourceRelationTypeStr
h-250b34abtargets_genehypothesis0.90
h-d78123d1targets_genehypothesis0.90
ARRB1activatesprotein0.85
h-250b34abtargetshypothesis0.80
JUNactivatesgene0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
RAB27A-dependent extracellular vesicle engineering for mitoc 0.414 neurodegeneration Mitochondrial transfer between astrocyte

Mentioning Analyses (2)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.450

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Tumour extracellular vesicles and particles induce liver metabolic dysfunction. [PMID:37225988] Wang G, Li J, Bojmar L, Chen H, Li Z, To Nature 2023 1
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironmen [PMID:37172577] Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang Cell Metab 2023 1
Rab27a and Rab27b control different steps of the exosome secretion pathway. [PMID:19966785] Ostrowski M, Carmo NB, Krumeich S, Fange Nat Cell Biol 2010 1
EVs-Mediated Intracardiac Crosstalk Mitigates Doxorubicin-Induced Cardiotoxicity [PMID:41948821] Wang H, Chen Y, Wang T, Ye X, Zhang X et Circ Res 2026 0
Autophagic extracellular vesicles: a distinct secretory route linking autophagy [PMID:41958120] Wei H, Fu Y Autophagy 2026 0
Case Report: Late-onset primary hemophagocytic lymphohistiocytosis leading to th [PMID:40852732] ["Rausch J", "Herold S", "Liebh\u00e4use Frontiers in immunology 2025 0
Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure. [PMID:38847080] Mallaredy V, Roy R, Cheng Z, Thej C, Ben Circulation research 2024 0
Interruption of p38 [PMID:38481807] ["Kim S", "Lee J", "Jung J", "Kim G", "Y International journal of biolo 2024 0
Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to [PMID:35849032] Liu X, Tan S, Liu H, Jiang J, Wang X, Li Hepatology (Baltimore, Md.) 2023 0
Autophagy and exosomes coordinately mediate quercetin's protective effects on al [PMID:36965782] ["Chen H", "Liu J", "Peng S", "Yang G", The Journal of nutritional bio 2023 0
Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast ac [PMID:37357686] Huang Q, Sun Y, Peng L, Sun J, Sha Z, Li Journal of extracellular vesic 2023 0
Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Ra [PMID:35701443] ["Pattanayak R", "Underwood R", "Crowley Scientific reports 2022 0
Capturing membrane trafficking events during 3D angiogenic development in vitro. [PMID:34415654] ["Francis C", "Kushner E"] Microcirculation (New York, N. 2022 0
In vivo Roles of Rab27 and Its Effectors in Exocytosis. [PMID:34483204] ["Izumi T"] Cell structure and function 2021 0
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. [PMID:29590046] ["Zhao L", "Zhang F", "Ding X", "Wu G", Science (New York, N.Y.) 2018 0
White matter microstructure in transsexuals and controls investigated by diffusi [PMID:25392513] ["Kranz G", "Hahn A", "Kaufmann U", "K\u The Journal of neuroscience : 2014 0
Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interacti [PMID:23201972] ["Klengel T", "Mehta D", "Anacker C", "R Nature neuroscience 2013 0