Epigenetic Clock Reversal via Metabolic Oscillator Coupling

graph TD
    AMPK_SIRT1_PGC1__axis["AMPK-SIRT1-PGC1α axis"] -->|associated with| neurodegeneration["neurodegeneration"]
    NAD__NADH_ratio["NAD+/NADH ratio"] -->|modulates| SIRT1_activity["SIRT1 activity"]
    SIRT1["SIRT1"] -->|regulates| chromatin_remodeling["chromatin_remodeling"]
    SIRT1_1["SIRT1"] -->|associated with| SIRT3["SIRT3"]
    SIRT1_2["SIRT1"] -->|targets| neurodegeneration_3["neurodegeneration"]
    SIRT1_4["SIRT1"] -.->|downregulated in| aging_neurons["aging neurons"]
    SIRT1_5["SIRT1"] -->|regulates| PGC1_["PGC1α"]
    SIRT1_6["SIRT1"] -->|regulates| nutrient_sensing["nutrient sensing"]
    SIRT1_7["SIRT1"] -->|modulates| metabolic_oscillators["metabolic oscillators"]
    SIRT1_8["SIRT1"] -->|regulates| epigenetic_clock["epigenetic clock"]
    SIRT1_activity_reduction["SIRT1 activity reduction"] -->|associated with| Alzheimer_disease["Alzheimer disease"]
    SIRT1_9["SIRT1"] -->|activates| FOXO_transcription_factor["FOXO transcription factors"]
    Protein_aggregation["Protein aggregation"] -->|causes| SIRT1_reduction["SIRT1 reduction"]
    AMPK_SIRT1_PGC1__axis_10["AMPK-SIRT1-PGC1α axis"] -->|regulates| Neurodegeneration["Neurodegeneration"]
    SIRT1_11["SIRT1"] -->|modulates| Mitochondrial_function["Mitochondrial function"]
    style AMPK_SIRT1_PGC1__axis fill:#81c784,stroke:#333,color:#000
    style neurodegeneration fill:#ef5350,stroke:#333,color:#000
    style NAD__NADH_ratio fill:#4fc3f7,stroke:#333,color:#000
    style SIRT1_activity fill:#4fc3f7,stroke:#333,color:#000
    style SIRT1 fill:#ce93d8,stroke:#333,color:#000
    style chromatin_remodeling fill:#81c784,stroke:#333,color:#000
    style SIRT1_1 fill:#ce93d8,stroke:#333,color:#000
    style SIRT3 fill:#ce93d8,stroke:#333,color:#000
    style SIRT1_2 fill:#ce93d8,stroke:#333,color:#000
    style neurodegeneration_3 fill:#ef5350,stroke:#333,color:#000
    style SIRT1_4 fill:#ce93d8,stroke:#333,color:#000
    style aging_neurons fill:#4fc3f7,stroke:#333,color:#000
    style SIRT1_5 fill:#ce93d8,stroke:#333,color:#000
    style PGC1_ fill:#4fc3f7,stroke:#333,color:#000
    style SIRT1_6 fill:#ce93d8,stroke:#333,color:#000
    style nutrient_sensing fill:#4fc3f7,stroke:#333,color:#000
    style SIRT1_7 fill:#ce93d8,stroke:#333,color:#000
    style metabolic_oscillators fill:#4fc3f7,stroke:#333,color:#000
    style SIRT1_8 fill:#4fc3f7,stroke:#333,color:#000
    style epigenetic_clock fill:#4fc3f7,stroke:#333,color:#000
    style SIRT1_activity_reduction fill:#4fc3f7,stroke:#333,color:#000
    style Alzheimer_disease fill:#ef5350,stroke:#333,color:#000
    style SIRT1_9 fill:#4fc3f7,stroke:#333,color:#000
    style FOXO_transcription_factor fill:#4fc3f7,stroke:#333,color:#000
    style Protein_aggregation fill:#4fc3f7,stroke:#333,color:#000
    style SIRT1_reduction fill:#4fc3f7,stroke:#333,color:#000
    style AMPK_SIRT1_PGC1__axis_10 fill:#81c784,stroke:#333,color:#000
    style Neurodegeneration fill:#4fc3f7,stroke:#333,color:#000
    style SIRT1_11 fill:#4fc3f7,stroke:#333,color:#000
    style Mitochondrial_function fill:#4fc3f7,stroke:#333,color:#000