Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPIGENETIC REGULATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | EPIGENETIC REGULATION |
| Key Genes/Proteins | MTOR |
| Related Diseases | CANCER |
| Linked Hypotheses | 9 hypotheses |
Knowledge base pages for this entity
graph TD
EPIGENETIC_REGULATION["EPIGENETIC REGULATION"]
EPIGENETIC_REGULATION -->|"regulates"| T_CELL_DIFFERENTIATION["T CELL DIFFERENTIATION"]
EPIGENETIC_REGULATION -->|"involved_in"| Pancreatic_Ductal_Adenocarcino["Pancreatic Ductal Adenocarcinoma"]
EPIGENETIC_REGULATION -->|"regulates"| senescence["senescence"]
EPIGENETIC_REGULATION -->|"causes"| Senescence["Senescence"]
EPIGENETIC_REGULATION -->|"regulates"| liver_brain_axis["liver-brain axis"]
EPIGENETIC_REGULATION -->|"regulates"| INFLAMMATION["INFLAMMATION"]
EPIGENETIC_REGULATION -->|"inhibits"| MTOR_SIGNALING["MTOR SIGNALING"]
TET2["TET2"] -->|"mediates"| EPIGENETIC_REGULATION
HDAC["HDAC"] -->|"mediates"| EPIGENETIC_REGULATION
ASXL1["ASXL1"] -->|"involved_in"| EPIGENETIC_REGULATION
lactylation["lactylation"] -->|"regulates"| EPIGENETIC_REGULATION
PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"regulates"| EPIGENETIC_REGULATION
BRD4["BRD4"] -->|"participates in"| EPIGENETIC_REGULATION
AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| EPIGENETIC_REGULATION| Target | Relation | Type | Str |
|---|---|---|---|
| T CELL DIFFERENTIATION | regulates | entity | 0.90 |
| INFLAMMATION | regulates | process | 0.50 |
| INFLAMMATION | co_discussed | process | 0.40 |
| NEUROINFLAMMATION | co_discussed | process | 0.40 |
| MITOCHONDRIAL DYSFUNCTION | co_discussed | process | 0.40 |
| SENESCENCE | co_discussed | process | 0.40 |
| METASTASIS | co_discussed | process | 0.40 |
| MTOR | co_discussed | gene | 0.40 |
| SYNAPTIC PLASTICITY | co_discussed | process | 0.40 |
| NEURODEGENERATION | co_discussed | process | 0.40 |
| HUNTINGTON | co_discussed | disease | 0.40 |
| HUNTINGTON'S DISEASE | co_discussed | disease | 0.40 |
| IMMUNE RESPONSE | co_discussed | process | 0.40 |
| MTOR SIGNALING | inhibits | process | 0.35 |
| METASTASIS | inhibits | process | 0.35 |
| TGF-BETA | regulates | gene | 0.35 |
| MITOCHONDRIAL DYSFUNCTION | regulates | process | 0.35 |
| NEUROINFLAMMATION | regulates | process | 0.35 |
| SYNAPTIC PLASTICITY | regulates | process | 0.35 |
| NEURODEGENERATION | regulates | process | 0.35 |
| HUNTINGTON | regulates | disease | 0.35 |
| IMMUNE RESPONSE | regulates | process | 0.35 |
| TET2 | regulates | gene | 0.35 |
| RETINA | regulates | brain_region | 0.35 |
| MMP9 | inhibits | gene | 0.30 |
| TP53 | regulates | gene | 0.30 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | mediated_by | process | 0.65 |
| AUTOPHAGY | regulates | process | 0.50 |
| NEUROINFLAMMATION | regulates | process | 0.50 |
| SENESCENCE | regulates | process | 0.50 |
| MITOCHONDRIAL DYSFUNCTION | regulates | process | 0.50 |
| INFLAMMATION | regulates | process | 0.50 |
| MTOR | inhibits | gene | 0.50 |
| CANCER | inhibits | disease | 0.50 |
| BEVACIZUMAB | associated_with | drug | 0.45 |
| CANCER | co_discussed | disease | 0.40 |
| DEPRESSION | co_discussed | disease | 0.40 |
| AGING | co_discussed | process | 0.40 |
| AUTOPHAGY | co_discussed | process | 0.40 |
| AKT | co_discussed | gene | 0.40 |
| BREAST CANCER | co_discussed | disease | 0.40 |
| CELL PROLIFERATION | co_discussed | process | 0.40 |
| ABCA1 | co_discussed | gene | 0.40 |
| CANCER | regulates | disease | 0.35 |
| CELL PROLIFERATION | inhibits | process | 0.35 |
| BREAST CANCER | inhibits | disease | 0.35 |
| AKT | inhibits | gene | 0.35 |
| AGING | regulates | process | 0.35 |
| DEPRESSION | regulates | disease | 0.35 |
| CHRONIC KIDNEY DISEASE | regulates | disease | 0.35 |
| CHRNA7 | activates | gene | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||