protein

IBA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IBA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

970Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

IBA1 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with AD, ALS, ALZHEIMER'S DISEASE. Connected to 250 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	IBA1
Full Name	Ionized Calcium-Binding Adapter Molecule 1
Function	is a protein encoded by the AIF1 gene that ### Microglial Marker
Molecular Weight	17.0 kDa
Amino Acids	147 aa
Pathways	Mapk
UniProt ID	[P55008](https://www.uniprot.org/uniprotkb/P55008)
GeneCards	IBA1
Human Protein Atlas	IBA1
Actin bundling	Crosslinks actin filaments into bundles
Membrane ruffling	Required for formation of membrane ruffles and lamellipodia
Motility	Essential for microglial migration and chemotaxis
Phagocytosis	Participates in phagocytic cup formation
Antigen presentation	Associated with MHC class II expression
Inflammatory signaling	Modulates cytokine production
Associated Diseases	AD, ALS, AMI, Aging, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	IL1B, SQSTM1, ASC, NLRP3, IL6, TNF
KG Connections	967 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IBA1["IBA1"]
    IBA1 -->|"expressed in"| ALS["ALS"]
    IBA1 -->|"activates"| Alzheimer["Alzheimer"]
    IBA1 -->|"activates"| Aging["Aging"]
    IBA1 -->|"inhibits"| Inflammation["Inflammation"]
    IBA1 -->|"inhibits"| Tumor["Tumor"]
    IBA1 -->|"inhibits"| Parkinson["Parkinson"]
    IBA1 -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| IBA1
    MICROGLIA["MICROGLIA"] -->|"expressed in"| IBA1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| IBA1
    ALZHEIMER["ALZHEIMER"] -->|"activates"| IBA1
    NLRP3["NLRP3"] -->|"inhibits"| IBA1
    UBIQUITIN["UBIQUITIN"] -->|"inhibits"| IBA1
    PARKINSON["PARKINSON"] -->|"inhibits"| IBA1
    SQSTM1["SQSTM1"] -->|"inhibits"| IBA1
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"inhibits"| IBA1

Outgoing (583)

Target	Relation	Type	Str
MICROGLIA	biomarker_for	entity	0.90
microglia	expressed_in	cell_type	0.90
Inflammation	activates	disease	0.85
astrocytes	expressed_in	cell_type	0.80
microglia	biomarker_for	cell_type	0.80
microglia	activates	cell_type	0.80
MICROGLIA	activates	cell_type	0.80
Aging	activates	disease	0.75
Neurodegeneration	inhibits	disease	0.75
Parkinson	activates	disease	0.75
Alzheimer	inhibits	disease	0.75
neuroinflammation	activates	disease	0.70
Nf-Κb	activates	pathway	0.70
NEURODEGENERATION	inhibits	gene	0.70
AMYLOID	inhibits	gene	0.70
ASTROCYTES	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
cortex	expressed_in	brain_region	0.70
Alzheimer's disease	regulates	disease	0.70
TNF	biomarker_for	gene	0.65
ALS	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Aging	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	activates	disease	0.65
Anxiety	activates	disease	0.65
Tumor	activates	disease	0.65
Depression	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	treats	disease	0.65
Tauopathy	treats	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Alzheimer	treats	disease	0.65
Dementia	treats	disease	0.65
Als	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65
Obesity	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (387)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
Dark Microglia	expressed_in	phenotype	0.90
Hearing Loss	upregulates	phenotype	0.90
NEUROINFLAMMATION	associated_with	gene	0.90
TLR2	upregulates	gene	0.82
MICROGLIA	associated_with	cell_type	0.82
AMYLOID	associated_with	protein	0.82
HEARING_LOSS	upregulates	phenotype	0.80
GINSENOSIDE_RO	downregulates	compound	0.80
APP	associated_with	gene	0.74
MICROGLIA	expressed_in	gene	0.74
MICROGLIA	activates	gene	0.74
PARKINSON'S DISEASE	associated_with	disease	0.74
GFAP	disrupts	gene	0.70
APOE	regulates	gene	0.70
liver disease	associated_with	disease	0.70
MTOR	associated_with	gene	0.66
IL-6	associated_with	gene	0.66
GFAP	interacts_with	gene	0.65
GFAP	biomarker_for	gene	0.65
GFAP	accumulates_in	gene	0.65
TLR4	inhibits	gene	0.65
DOPAMINERGIC	associated_with	cell_type	0.65
NEURODEGENERATION	protects_against	disease	0.65
AMYLOID	regulates	protein	0.65
NLRP3	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
AIF1	associated_with	gene	0.60
SQSTM1	inhibits	gene	0.60
GAPDH	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
TNF	inhibits	gene	0.60
ATG5	associated_with	gene	0.60
IL1B	inhibits	gene	0.60
ASC	inhibits	gene	0.60
CASP1	associated_with	gene	0.60
SNCA	inhibits	gene	0.60
ATG7	associated_with	gene	0.60
MAP1LC3B	inhibits	gene	0.60
IL6	inhibits	gene	0.60
BECN1	associated_with	gene	0.60
PYCARD	inhibits	gene	0.60
TLR4	activates	gene	0.60
POLE	activates	gene	0.60
NLRP3	associated_with	gene	0.60
MYD88	activates	gene	0.60
ICAM1	activates	gene	0.60
BMAL1	activates	gene	0.60
TNFRSF1A	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What causes IBA1 low/negative microglia in liver disease and how does this affec

neuroinflammation | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IBA1

Understanding Entity Pages

Summary

Wiki Pages (21)

IBA1 Protein

Corticobasal Syndrome (CBS)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

nhp-validation-animal-model

Microglial Cells — Cell Type Hierarchy

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

vitamin-d-therapy-neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

rapamycin-tauopathy

mitochondrial-dynamics-dysfunction-parkinsons

Blarcamesine

tudca-udca-neurodegeneration

Neuroinflammation in Parkinson's Disease

Astrocyte Metabolic Enhancement Therapy for PD

Viral Vector Delivery Investment Landscape for Neurodegeneration

Neuroinflammation Microglia

methylene-blue-neurodegeneration

Lewy Body Formation

TREM2 in Parkinson's Disease — Cross-Disease Therapeutic Opportunity