protein

LXR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LXR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

105Connections

10Hypotheses

1Analyses

50Outgoing

45Incoming

0Experiments

1Debates

Summary

Page for LXR Protein (Liver X Receptor)

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🔬 Protein Info

Gene Symbol	LXR
Aliases	Liver X Receptor
Pathways	NF-κB
GeneCards	LXR
Human Protein Atlas	LXR
Associated Diseases	ALS, Alzheimer, glioblastoma, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ABCA1, ABCA7, ABCG1, ACAT1, AKT, AMPK
SciDEX Hypotheses	Upstream restoration of glial lipid efflux and apo
KG Connections	104 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    LXR(["LXR"])
    CD38(["CD38"])
    S1PR1["S1PR1"]
    Kupffer_Cell_Survival("Kupffer Cell Survival")
    Cholesterol_Efflux("Cholesterol Efflux")
    S1P1["S1P1"]
    AP_1(["AP-1"])
    SREBP1["SREBP1"]
    Metabolic_Stress("Metabolic Stress")
    KUPFFER_CELLS["KUPFFER_CELLS"]

    LXR -->|"upregulates"| CD38
    S1PR1 -->|"activates"| LXR
    LXR -->|"regulates"| Kupffer_Cell_Survival
    LXR -->|"regulates"| Cholesterol_Efflux
    S1P1 -->|"upregulates"| LXR
    AP_1 -->|"modulates"| LXR
    LXR -->|"regulates"| SREBP1
    Metabolic_Stress -->|"activates"| LXR
    LXR -->|"regulates"| KUPFFER_CELLS

    style LXR fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (60)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.90
Cholesterol Efflux	regulates	process	0.85
Kupffer Cell Survival	regulates	process	0.85
cholesterol homeostasis	participates_in	pathway	0.85
SREBP1	regulates	entity	0.80
APOE4	regulates	protein	0.80
TAU	regulates	protein	0.80
unfolded protein response	participates_in	pathway	0.75
lipid metabolism	participates_in	pathway	0.70
ABCA1/ABCG1	activates	gene	0.70
neuroinflammation	activates	disease	0.65
cardiovascular disease	regulates	disease	0.60
glioblastoma	associated_with	disease	0.60
TNF	expressed_in	gene	0.60
PPAR	regulates	gene	0.60
neurodegeneration	associated_with	disease	0.60
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
T cells	expressed_in	cell_type	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
cardiovascular disease	activates	disease	0.60
TREM2	inhibits	gene	0.60
neurodegeneration	inhibits	disease	0.60
MAF	activates	gene	0.60
neurodegeneration	protects_against	disease	0.60
Alzheimer's disease	inhibits	disease	0.60
apoptosis pathway	participates_in	pathway	0.60
oligodendrocytes	expressed_in	cell_type	0.60
PI3K	activates	gene	0.60
PKA	activates	gene	0.60
MAPK	activates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
RNA	inhibits	gene	0.60
glioblastoma	inhibits	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
neurodegeneration	regulates	disease	0.60
NLRP3	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
PPAR	activates	gene	0.60
neurodegeneration	activates	disease	0.60
Alzheimer's disease	activates	disease	0.60
multiple sclerosis	activates	disease	0.60
MAPK signaling	participates_in	pathway	0.60
Alzheimer's disease	expressed_in	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
KUPFFER_CELLS	regulates	cell_type	0.56
TNF	activates	gene	0.55
macrophages	expressed_in	cell_type	0.55
SOAT1	activates	gene	0.55

Incoming (45)

Source	Relation	Type	Str
29563219	regulates transcription of	paper	0.90
S1P1	upregulates	receptor	0.85
AP-1	modulates	protein	0.85
ATP	activates	gene	0.70
APOE	expressed_in	gene	0.70
ABCA1	activates	gene	0.65
CYP46A1	activates	gene	0.65
APOE	associated_with	gene	0.65
GBM	inhibits	gene	0.60
ACAT1	activates	gene	0.60
APOE	regulates	gene	0.60
AQP4	regulates	gene	0.60
ABCA1	inhibits	gene	0.60
ACAT1	inhibits	gene	0.60
ABCA1	associated_with	gene	0.60
LRP1	activates	gene	0.60
APP	expressed_in	gene	0.60
APOE4	activates	gene	0.60
LDL	activates	gene	0.60
AKT	activates	gene	0.60
AMPK	activates	gene	0.60
rapamycin	targets	drug	0.60
IRF8	activates	gene	0.60
ABCA1	expressed_in	gene	0.60
ABCA7	expressed_in	gene	0.60
ABCG1	expressed_in	gene	0.60
GAS6	expressed_in	gene	0.60
ABCA7	activates	gene	0.60
ABCG1	activates	gene	0.60
GAS6	activates	gene	0.60
ABCA1	regulates	gene	0.60
ABCA7	regulates	gene	0.60
ABCG1	regulates	gene	0.60
GAS6	regulates	gene	0.60
APOE	protects_against	gene	0.55
DGAT1	activates	gene	0.55
APOE	activates	gene	0.55
APP	activates	gene	0.55
APOE3	co_expressed_with	protein	0.50
APOE4	co_expressed_with	gene	0.50
ABCA7	co_expressed_with	gene	0.50
GBM	co_expressed_with	gene	0.50
HMGCR	co_expressed_with	gene	0.50
LDLR	co_expressed_with	gene	0.50
CYP46A1	co_expressed_with	gene	0.50

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective LXRβ agonists restore ABCA1/ABCG1 expression and A	0.728	neuroscience	APOE4-driven lipid metabolism dysregulat
LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-	0.721	neurodegeneration	What specific molecular mechanisms link
LXRβ-Selective Agonism to Simultaneously Enhance APOE Lipida	0.668	lipidomics	Lipid metabolism dysregulation in Alzhei
OPC Maturation Block via PDGFRA/LXRβ	0.620	neurodegeneration	Methodology challenge: dataset 'Allen Br
Upstream restoration of glial lipid efflux and apoE lipidati	0.584	molecular biology	Does APOE4's reduced lipid-binding direc

LXR Agonism (H4): Microglial Lipid Efflux Promotion	0.580	neurodegeneration	Does restoring neuronal AMPK activity re
LXRβ-Selective Agonism Enhances CYP2J2-Mediated DHA Epoxide	0.380	lipidomics	Lipid metabolism dysregulation in Alzhei
LXRα-Selective Agonism to Enhance Hepatic APOE Secretion and	0.380	lipidomics	Lipid metabolism dysregulation in Alzhei
ABCA1 Upregulation via LXRβ Agonism to Enhance Cholesterol E	0.380	lipidomics	Lipid metabolism dysregulation in Alzhei
CYP2J2-Generated DHA Epoxides Enhance LXRβ-Mediated APOE Lip	0.380	lipidomics	Lipid metabolism dysregulation in Alzhei

Mentioning Analyses (1)

Scientific analyses that reference this entity

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.721

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract identifies APOE4's primary effect on oligodendrocyte cholesterol me

closed · Rounds: 4 · Score: 0.69 · 2026-04-16

Related Research

Hypotheses and analyses mentioning LXR in their description or question text

LXR Agonism (H4): Microglial Lipid Efflux Promotion

Score: 0.580 · neurodegeneration · 2026-04-25

GW3965-mediated LXR activation promotes cholesterol efflux via ABCA1/ABCG1, enabling microglia to handle increased neuro

LXRβ-Selective Agonism Enhances CYP2J2-Mediated DHA Epoxide Generation to Restor

Score: 0.380 · lipidomics · 2026-04-27

This hypothesis proposes that LXRβ-selective agonists enhance CYP2J2 expression and activity to increase protective DHA

LXRα-Selective Agonism to Enhance Hepatic APOE Secretion and Peripheral Choleste

Score: 0.380 · lipidomics · 2026-04-27

This hypothesis proposes that selective activation of LXRα (NR1H3) represents a superior therapeutic approach for addres

ABCA1 Upregulation via LXRβ Agonism to Enhance Cholesterol Efflux and Prevent Ne

Score: 0.380 · lipidomics · 2026-04-26

This hypothesis proposes that selective LXRβ agonism primarily functions through transcriptional upregulation of ABCA1 (

CYP2J2-Generated DHA Epoxides Enhance LXRβ-Mediated APOE Lipidation for Synergis