concept

AMI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

113Connections

12Hypotheses

18Analyses

0Outgoing

50Incoming

Summary

AMI is a concept in neurodegeneration research. Key relationships include: implicated in, associated with. Connected to 113 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AMI
Key Genes/Proteins	MMP9, MAP1B, MAP2, MAP6, RAB7A, LRP2
Linked Hypotheses	35 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    AMI["AMI"]
    MAP1B["MAP1B"] -->|"implicated in"| AMI
    MAP2["MAP2"] -->|"implicated in"| AMI
    MAP6["MAP6"] -->|"implicated in"| AMI
    RAB7A["RAB7A"] -->|"implicated in"| AMI
    LRP2["LRP2"] -->|"implicated in"| AMI
    ACTB["ACTB"] -->|"implicated in"| AMI
    CTSD["CTSD"] -->|"implicated in"| AMI
    ATG["ATG"] -->|"implicated in"| AMI
    EGFR["EGFR"] -->|"implicated in"| AMI
    SREBF1["SREBF1"] -->|"implicated in"| AMI

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (113)

Source	Relation	Type	Str
MMP9	associated_with	protein	0.72
MAP1B	implicated_in	gene	0.50
MAP2	implicated_in	gene	0.50
MAP6	implicated_in	gene	0.50
RAB7A	implicated_in	gene	0.50
LRP2	implicated_in	gene	0.50
ACTB	implicated_in	gene	0.50
CTSD	implicated_in	gene	0.50
ATG	implicated_in	gene	0.50
EGFR	implicated_in	gene	0.50
SREBF1	implicated_in	gene	0.50
NADH	implicated_in	gene	0.50
MTORC1	implicated_in	gene	0.50
PPARG	implicated_in	gene	0.50
RPS6KB1	implicated_in	gene	0.50
PPARA	implicated_in	gene	0.50
LAMP1	implicated_in	gene	0.50
RUBCN	implicated_in	gene	0.50
MTOR	implicated_in	gene	0.50
RAS	implicated_in	gene	0.50
RPS6	implicated_in	gene	0.50
PIK3C3	implicated_in	gene	0.50
ATP	implicated_in	gene	0.50
SQSTM1	implicated_in	gene	0.50
CAT	implicated_in	gene	0.50
PPAR	implicated_in	gene	0.50
ROS	implicated_in	gene	0.50
BACE1	implicated_in	gene	0.50
LIS1	implicated_in	gene	0.50
DCX	implicated_in	gene	0.50
RELN	implicated_in	gene	0.50
APOE	implicated_in	gene	0.50
HCN1	implicated_in	gene	0.50
HCN4	implicated_in	gene	0.50
HCN2	implicated_in	gene	0.50
SLC16A2	implicated_in	gene	0.50
SLC16A1	implicated_in	gene	0.50
GSS	implicated_in	gene	0.50
CYP2E1	implicated_in	gene	0.50
IDH2	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50
VEGFA	implicated_in	gene	0.50
EEF1A1	implicated_in	gene	0.50
APOB	implicated_in	gene	0.50
MET	implicated_in	gene	0.50
MCL1	implicated_in	gene	0.50
SF3B1	implicated_in	gene	0.50
SMARCA4	implicated_in	gene	0.50
DNA	implicated_in	gene	0.50
LZTR1	implicated_in	gene	0.50

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.674	neuroimmunology	What is the temporal sequence of TREM2 s
HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting	0.526	synaptic biology	How do P/Q channel deficits paradoxicall
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio	0.494	neuroscience	Circuit-level neural dynamics in neurode
Transglutaminase-2 Cross-Linking Inhibition Strategy	0.488	neurodegeneration	Protein aggregation cross-seeding across
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.486	translational neuroscience	Which metabolic biomarkers can distingui

Glycosaminoglycan Template Disruption Approach	0.464	neurodegeneration	Protein aggregation cross-seeding across
Lipid Droplet Dynamics as Phenotype Switches	0.463	neurodegeneration	Astrocyte reactivity subtypes in neurode
Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neur	0.435	translational neuroscience	Which metabolic biomarkers can distingui
Lysosomal Positioning Dynamics Modulation	0.430	neurodegeneration	Autophagy-lysosome pathway convergence a
Correcting Gut Microbial Dopamine Imbalance to Support Syste	0.412	neurodegeneration	What are the mechanisms by which gut mic
BH4 Cofactor Restoration as Primary Driver of >500-Fold Dopa	0.396	neurodegeneration	What molecular mechanisms underlie Atrem
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis	0.364	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (18)

Scientific analyses that reference this entity

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.606

How do P/Q channel deficits paradoxically increase thalamic excitability despite

synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

neurodegeneration | 2026-04-12 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lin [PMID:39237833]	Schöbel A, Pinho Dos Reis V, Burkhard R,	Commun Biol	2024	1
Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propag [PMID:39233232]	Bayati A, McPherson PS	J Biol Chem	2024	1
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM17 [PMID:37390818]	Zhang J, Zeng W, Han Y, Lee WR, Liou J,	Mol Cell	2023	1
Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage. [PMID:36009491]	Kou Y, Geng F, Guo D	Biomedicines	2022	1
Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279]	Saffire H Krance, Che-Yuan Wu, Alison C	Journal of Alzheimer's disease	2022	1
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641]	Zhang X, Wei M, Fan J, Yan W, Zha X, Son	Autophagy	2021	1
Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovi [PMID:32899450]	Kajdasz A, Warzych E, Derebecka N, Madej	Int J Mol Sci	2020	1
TGM2 and implications for human disease: role of alternative splicing. [PMID:23276939]	Lai TS, Greenberg CS	Front Biosci (Landmark Ed)	2013	1
Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. [PMID:16973206]	Eskelinen EL	Mol Aspects Med	2006	1
Enhancing the efficiency of bone tissue regeneration by using a 3D printed scaff [PMID:41435437]	Ku CY, Chen YH, Lin CM, Chu YH, Ho YJ, L	Biomedical materials (Bristol,	2026	0
Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration a [PMID:41546868]	["Tabor G", "Litvinchuk A", "Chen Y", "A	Cell reports	2026	0
Efficacy of Der f 2/Zen 1-LAMP1 Plasmid-Based Vaccine Immunotherapy in Dogs With [PMID:41287364]	Bizikova P, Matsumoto C, Ogino S, Tsukui	Vet Dermatol	2026	0
Measuring lysosome damage and lysophagy in vivo. [PMID:41485143]	Wu Z, Zhan H, Huang Z, Wang C, Li B et a	Autophagy	2026	0
Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198]	Xiao F, Tan X, He A, Zhou Y, Xu K et al.	Autophagy	2026	0
Preparation of a polyclonal antibody against Lysosome-Associated Membrane Protei [PMID:41825675]	Luo J, Shi Y, Jiang X, Zhang B, Chen Y e	Int J Biol Macromol	2026	0
Increased Glycogenin-Exposed Residual Glycogen in Lysosomes Is the Early Patholo [PMID:41923452]	Shi Y, Zhang N, Sun H, Wang Y, Zhao D et	Muscle Nerve	2026	0
Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat [PMID:41925987]	Al Saeedy DY, Hawkins E, Dozmorov MG, Tr	J Mol Neurosci	2026	0
A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders [PMID:41699128]	["Bolsewig K", "Bellomo G", "Hok-A-Hin Y	Nature medicine	2026	0
Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial [PMID:40619121]	Zhou G, Zhang M, Zheng S, Yang G, Li L e	J Adv Res	2026	0
Anti-Proliferative Effects of Resveratrol on Gingival Fibroblasts Derived From A [PMID:41964344]	Kara B, Saygun NI, Köse Özkan C, Özgül S	J Periodontal Res	2026	0

AMI

Understanding Entity Pages

Summary

Wiki Pages (20)

Neurons — Cell Type Hierarchy

PEN2 Gene

Beta-Secretase (BACE1) Protein

PSEN2 — Presenilin 2

Complement-Mediated Synapse Loss

Pathway Diagram

Outgoing (0)

Incoming (113)

Targeting Hypotheses (12)

Mentioning Analyses (18)

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

How do P/Q channel deficits paradoxically increase thalamic excitability despite

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

What determines the temporal transition from protective to pathological stress g

What is the therapeutic window between GCS inhibition efficacy and systemic toxi

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

How do pathological stress granules transition from reversible to persistent in

Epigenetic reprogramming in aging neurons

How do astrocyte-neuron metabolic interactions change during disease progression

Human connectome alterations and network-level dysfunction in Alzheimer disease

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Circuit-level neural dynamics in neurodegeneration

Circuit-level neural dynamics in neurodegeneration

Related Papers (20)

AMI

Understanding Entity Pages

Summary

Wiki Pages (20)

Neurons — Cell Type Hierarchy

PEN2 Gene

Beta-Secretase (BACE1) Protein

PSEN2 — Presenilin 2

Complement-Mediated Synapse Loss

Amylin Signaling in Neurodegeneration

CD33 — Cluster of Differentiation 33

MAP6 Gene

yale-university

eef1a1

BACE1 Protein

GABAergic Neurons — Cell Type Hierarchy

prefrontal-cortex

CERS2 Protein (Ceramide Synthase 2)

ABCG1 Gene

Salience Network

AD RNA-Based Therapeutics Companies

PSEN1 — Presenilin 1

oregon-health-and-science-university

TERT Gene

Pathway Diagram

Outgoing (0)

Incoming (113)

Targeting Hypotheses (12)

Mentioning Analyses (18)

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

How do P/Q channel deficits paradoxically increase thalamic excitability despite

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

What determines the temporal transition from protective to pathological stress g

What is the therapeutic window between GCS inhibition efficacy and systemic toxi

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

How do pathological stress granules transition from reversible to persistent in

Epigenetic reprogramming in aging neurons

How do astrocyte-neuron metabolic interactions change during disease progression

Human connectome alterations and network-level dysfunction in Alzheimer disease

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Circuit-level neural dynamics in neurodegeneration

Circuit-level neural dynamics in neurodegeneration

Related Papers (20)