disease

Lupus

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Lupus: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

310Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

No summary available yet. View on Wiki →

Disease Info
Associated GenesCANCER, AUTOPHAGY, MITOCHONDRIA, FAS, DIABETES MELLITUS, ATG16L2, BECN1, ATG5
KG Connections301 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

Wiki Pages (20)

Knowledge base pages for this entity

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protein · 4393 words

Cerebral Small Vessel Disease

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RASGRP1 Gene

gene · 3531 words

IL28B (Interleukin 28B)

gene · 3405 words

CR1 Gene — Complement Component 1q Receptor

gene · 3403 words

Pathway Diagram

graph TD
    Lupus["<b>Lupus</b>"]
    Als{"Als"}
    Lupus -->|"therapeutic_target"| Als
    Apoptosis["Apoptosis"]
    Lupus -->|"therapeutic_target"| Apoptosis
    Autoimmune{"Autoimmune"}
    Lupus -->|"contributes_to"| Autoimmune
    Nf__b["Nf-Kappab"]
    Lupus -->|"therapeutic_target"| Nf__b
    CYTOKINES(["CYTOKINES"])
    CYTOKINES -->|"activates"| Lupus
    APOPTOSIS(["APOPTOSIS"])
    APOPTOSIS -->|"therapeutic_target"| Lupus
    IL_6(["IL-6"])
    IL_6 -->|"activates"| Lupus
    CGAS(["CGAS"])
    CGAS -->|"regulates"| Lupus
    style Lupus fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (122)

TargetRelationTypeStr
Alstherapeutic_targetdisease0.85
Alsactivatesdisease0.85
Apoptosistherapeutic_targetpathway0.80
Autoimmunecontributes_todisease0.75
Autoimmuneregulatesdisease0.75

Incoming (188)

SourceRelationTypeStr
CYTOKINESactivatesgene0.95
APOPTOSIStherapeutic_targetgene0.85
IL-6activatesgene0.85
CGASregulatesgene0.85
STAT3therapeutic_targetgene0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found