concept

PCK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PCK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

108Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

0Experiments

0Debates

Summary

PCK1 is a concept in neurodegeneration research. Key relationships include: therapeutic target, activates, interacts with. Associated with ALS, Aging, Als. Connected to 59 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PCK1
Key Genes/Proteins	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, BAX
Related Diseases	Aging, Als, ALS, Alzheimer, Cancer
Related Pathways	Apoptosis, Blood-Brain Barrier

Pathway Diagram

graph TD
    PCK1["<b>PCK1</b>"]
    PCK1 -->|"activates"| Als["Als"]
    PCK1 -->|"activates"| Aging["Aging"]
    PCK1 -->|"regulates"| Ms["Ms"]
    PCK1 -.protects against.-> Fibrosis["Fibrosis"]
    PCK1 -->|"activates"| Hepatitis["Hepatitis"]
    PCK1 -->|"activates"| Carcinoma["Carcinoma"]
    PCK1 -->|"activates"| Cancer["Cancer"]
    PCK1 -->|"interacts"| Tumor["Tumor"]
    PCK1 -->|"target for"| Alzheimer["Alzheimer"]
    CD8["CD8"] -->|"regulates"| PCK1
    PER["PER"] -->|"interacts"| PCK1
    CD36["CD36"] -->|"interacts"| PCK1
    CANCER["CANCER"] -->|"interacts"| PCK1
    LPL["LPL"] -->|"interacts"| PCK1
    PPARGC1A["PPARGC1A"] -->|"interacts"| PCK1
    PPARG["PPARG"] -->|"interacts"| PCK1
    CXCL1["CXCL1"] -->|"target for"| PCK1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"target for"| PCK1
    SOCS3["SOCS3"] -->|"target for"| PCK1
    IL6["IL6"] -->|"target for"| PCK1
    MICROGLIA["MICROGLIA"] -->|"target for"| PCK1

Outgoing (71)

Target	Relation	Type	Str
Als	activates	disease	0.75
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Aging	activates	disease	0.65
Aging	methylates	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
ALS	activates	disease	0.65
Aging	associated_with	disease	0.65
Diabetes	inhibits	disease	0.65
Hepatitis	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Ischemia	activates	disease	0.65
ALS	regulates	disease	0.65
Fibrosis	protects_against	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
glycogen_metabolism	regulates	pathway	0.64
AGING	activates	gene	0.60
PER	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
CD36	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
AND	regulates	gene	0.60
Ubiquitin	activates	protein	0.60
Rb	regulates	protein	0.60
Lipid Metabolism	interacts_with	pathway	0.60
Oxidative Phosphorylation	interacts_with	pathway	0.60
CD163	therapeutic_target	gene	0.60
MITOCHONDRIA	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
Apoptosis	activates	pathway	0.60
AND	causes	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
IL6	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
ICAM1	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
HSPB1	therapeutic_target	gene	0.60
SOCS3	therapeutic_target	gene	0.60
IL-6	associated_with	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60

Incoming (37)

Source	Relation	Type	Str
PPARA	associated_with	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
AND	regulates	gene	0.60
PER	interacts_with	gene	0.60
CD36	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
LPL	interacts_with	gene	0.60
PPARGC1A	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
ICAM1	associated_with	gene	0.60
CXCL1	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
SOCS3	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
AGING	activates	gene	0.60
BAX	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
FOXO1	activates	gene	0.60
AND	interacts_with	gene	0.60
ZFP36	therapeutic_target	gene	0.60
IL-6	associated_with	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
HSPB1	therapeutic_target	gene	0.60
SERPINA3	therapeutic_target	gene	0.60
SIRT1	activates	gene	0.60
Β-HYDROXYBUTYRATE	regulates	gene	0.60
SIRT1	methylates	gene	0.60
GSK3	activates	gene	0.60
AGING	methylates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
AND	causes	gene	0.60
CD8	regulates	gene	0.60
C5AR1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
SIRT1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity