concept

B CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

537Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

B CELL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, inhibits. Associated with GLIOBLASTOMA, LYMPHOMA, TUMOR. Connected to 30 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	B CELL
Key Genes/Proteins	AMPK, AQP4, BCL2
Related Diseases	CANCER

Pathway Diagram

graph TD
    B_CELL["B CELL"]
    TCR["TCR"] -->|"expressed in"| B_CELL
    CD40["CD40"] -->|"expressed in"| B_CELL
    CANCER["CANCER"] -->|"expressed in"| B_CELL
    AQP4["AQP4"] -->|"expressed in"| B_CELL
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| B_CELL
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| B_CELL
    CD19["CD19"] -->|"expressed in"| B_CELL
    ASTROCYTE["ASTROCYTE"] -->|"expressed in"| B_CELL
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"expressed in"| B_CELL
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| B_CELL

Outgoing (128)

Target	Relation	Type	Str
NEUROMYELITIS OPTICA SPECTRUM DISORDER	involved_in	entity	0.90
Neuromyelitis Optica Spectrum Disorder	associated_with	disease	0.90
Igg	expressed_in	protein	0.90
ST6Gal1	expressed_in	enzyme	0.90
Aqp4-Igg	associated_with	biomarker	0.88
Neuromyelitis optica spectrum disorder activity	biomarker_for	disease	0.80
CANCER	inhibits	disease	0.65
P53	inhibits	gene	0.65
BCL2	regulates	gene	0.65
LYMPHOMA	causes	disease	0.65
IL-6	inhibits	gene	0.65
LYMPHOMA	reduces	disease	0.65
NEUTROPHIL	increases	cell_type	0.65
MACROPHAGE	regulates	cell_type	0.60
MACROPHAGES	regulates	cell_type	0.60
NEURONS	activates	cell_type	0.60
NEURON	activates	cell_type	0.60
CHAT	activates	gene	0.60
TUMOR	inhibits	disease	0.60
MYC	activates	gene	0.60
GFAP	activates	gene	0.60
LYMPHOMA	inhibits	disease	0.60
STING	causes	gene	0.60
T CELLS	activates	cell_type	0.60
T CELL	activates	cell_type	0.60
MONOCYTE	promotes	cell_type	0.60
MONOCYTES	promotes	cell_type	0.60
CR1	co_discussed	entity	0.50
NEURON	co_discussed	cell_type	0.50
Cortex	expressed_in	brain_region	0.50
GPX4	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
PERICYTES	co_discussed	entity	0.50
GFAP	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
T CELLS	activates	concept	0.50
STEM CELLS	activates	concept	0.50
NEUTROPHILS	activates	concept	0.50
DENDRITIC CELLS	activates	concept	0.50
MONOCYTE	activates	concept	0.50
MONOCYTES	activates	concept	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50
CYTOKINE	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
CHOLESTEROL	co_discussed	entity	0.50
CGAS	co_discussed	entity	0.50
CASP1	co_discussed	entity	0.50
HISTONE	co_discussed	entity	0.50
MS	co_discussed	entity	0.50

Incoming (409)

Source	Relation	Type	Str
Inebilizumab	downregulates	drug	0.90
AMPK	activates	gene	0.65
CHAT	activates	gene	0.60
TIMMDC1	associated_with	gene	0.60
PGS1	associated_with	gene	0.60
BCS1L	associated_with	gene	0.60
IL-17	therapeutic_target	gene	0.60
RNA	activates	gene	0.60
IL-1	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
DR5	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
TRAIL	therapeutic_target	gene	0.60
BCL-2	therapeutic_target	gene	0.60
CARD8	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
NLRP1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
IL-1	associated_with	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
TLR	activates	gene	0.60
ROS	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
LYRM7	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
MRPS31	associated_with	gene	0.60
IBA1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
TLR7	therapeutic_target	gene	0.60
CXCR4	activates	gene	0.60
CD38	activates	gene	0.60
CXCR3	activates	gene	0.60
RNA	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
CD19	biomarker_for	gene	0.60
JUN	therapeutic_target	gene	0.60
IRF4	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
AQP4	activates	gene	0.60
RNA	biomarker_for	gene	0.60
GJA1	therapeutic_target	gene	0.60
CCL2	therapeutic_target	gene	0.60
DNA	regulates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CD4	associated_with	gene	0.60
FOS	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.738	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning B CELL in their description or question text

No additional research found