| Gene Symbol | DRD2 |
| Full Name | Dopamine Receptor D2 |
| Chromosome | 11q23.2 |
| Protein Type | Gpcr |
| Target Class | Gpcr |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Small molecule agonist or antagonist modulating dopamine signaling |
| Primary Expression | Striatum, Substantia nigra, Pituitary, Cortex |
| Druggability | High (0.90) |
| Clinical Stage | Approved |
| Pathways | PI3K |
| UniProt ID | P14416 |
| NCBI Gene ID | 1819 |
| Ensembl ID | ENSG00000149295 |
| GeneCards | DRD2 |
| Human Protein Atlas | DRD2 |
| Associated Diseases | ALS, Addiction, Alzheimer, Autism, Bipolar |
| Known Drugs/Compounds | L-DOPA, levodopa, UNC9995, D-520, quinpirole |
| Interactions | SNCA, JUN, HRH3, HCRTR2, ADRA1B, DRD1 |
| SciDEX Target | View Target Profile (6 clinical trials) |
| KG Connections | 809 knowledge graph edges |
| Databases | GeneCardsHPASTRING |