concept

PPP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

PPP3 is a concept in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 111 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PPP3
Key Genes/Proteins	TFEB, GLA
Related Diseases	Neurodegeneration, Amyotrophic Lateral Sclerosis, Parkinson, Als, Ataxia

Wiki Pages (2)

Knowledge base pages for this entity

TFEB (Redirect)

redirect · 624 words

→

Calcineurin Protein

protein · 604 words

→

Pathway Diagram

graph TD
    PPP3["PPP3"]
    PPP3 -->|"phosphorylates"| TFEB["TFEB"]
    PPP3 -->|"activates"| BECN1["BECN1"]
    PPP3 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    PPP3 -->|"interacts"| Als["Als"]
    PPP3 -->|"activates"| Ms["Ms"]
    PPP3 -->|"activates"| ATG10["ATG10"]
    PPP3 -->|"activates"| Mtor["Mtor"]
    PPP3 -->|"activates"| Autophagy["Autophagy"]
    PPP3 -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    trehalose["trehalose"] -->|"activates"| PPP3
    GENES["GENES"] -->|"activates"| PPP3
    CALCINEURIN["CALCINEURIN"] -->|"activates"| PPP3
    ATG12["ATG12"] -->|"activates"| PPP3
    PPP3CB["PPP3CB"] -->|"activates"| PPP3
    SMURF1["SMURF1"] -->|"regulates"| PPP3
    TFEB -->|"activates"| PPP3
    MTOR["MTOR"] -->|"activates"| PPP3
    LGALS3["LGALS3"] -->|"interacts"| PPP3
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"regulates"| PPP3

Outgoing (74)

Target	Relation	Type	Str
TFEB	phosphorylates	gene	0.90
Neurodegeneration	activates	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	activates	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
TFEB	activates	gene	0.64
GLA	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
ATG10	activates	gene	0.60
STIP1	associated_with	gene	0.60
TREH	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
Mtor	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Mtor	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Chaperone	associated_with	pathway	0.60
SOD1	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
ATG	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
ATG12	activates	gene	0.60
BECN1	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
BCL2	associated_with	gene	0.60

Incoming (82)

Source	Relation	Type	Str
Lysosomal Membrane Permeabilization	activates	process	0.80
trehalose	activates	drug	0.64
PPP3CB	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
P62	associated_with	gene	0.60
ATG	associated_with	gene	0.60
GENES	activates	gene	0.60
LAMP2A	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
BAG3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ATG12	activates	gene	0.60
PPP3CB	activates	gene	0.60
SMURF1	regulates	gene	0.60
TFEB	activates	gene	0.60
MTOR	activates	gene	0.60
LGALS3	interacts_with	gene	0.60
LYSOSOMAL BIOGENESIS	regulates	gene	0.60
MTORC1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
TREHALOSE	activates	gene	0.60
DNA	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ALS	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
TREH	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
CTSB	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
ATG10	activates	gene	0.60
GLA	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
RNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found