gene

NFKBIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKBIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

326Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NFKBIA is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, biomarker for. Associated with Als, Alzheimer, Cancer. Connected to 133 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NFKBIA
Full Name	NFKB Inhibitor Alpha
Chromosome	14q13
Molecular Weight	37 kDa
Amino Acids	317 aa
Exons	7 exons encoding the IκBα protein
Pathways	NFKB, NF-κB
UniProt ID	P19838
NCBI Gene ID	4792
Ensembl ID	ENSG0000096927
OMIM	164008
GeneCards	NFKBIA
Human Protein Atlas	NFKBIA
Promoter	Contains NF-κB binding sites, making expression auto-regulatory
3' UTR	Contains AU-rich elements (AREs) regulating mRNA stability
Associated Diseases	Hepatitis, Inflammation, Ms
Interactions	PGC1A, LPL, CLOCK, SIRT1, PPARG, NLRP3
KG Connections	325 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFKBIA — AlphaFold P19838 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Geniposide for Alzheimer's disease - immune biomarker targeting and therapeutic potential

mechanism · 1885 words

→

MYH2 Gene

gene · 1549 words

→

Pathway Diagram

graph TD
    NFKBIA["NFKBIA"]
    NFKBIA -.biomarker for.-> Als["Als"]
    NFKBIA -->|"regulates"| Parkinson["Parkinson"]
    NFKBIA -->|"regulates"| Ms["Ms"]
    NFKBIA -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    NFKBIA -->|"regulates"| Inflammation["Inflammation"]
    NFKBIA -->|"activates"| Cancer["Cancer"]
    NFKBIA -->|"activates"| Tumor["Tumor"]
    NFKBIA -.biomarker for.-> Apoptosis["Apoptosis"]
    TRAF6["TRAF6"] -.biomarker for.-> NFKBIA
    P38["P38"] -.biomarker for.-> NFKBIA
    CD4["CD4"] -.biomarker for.-> NFKBIA
    EGR2["EGR2"] -.biomarker for.-> NFKBIA
    TNF["TNF"] -.biomarker for.-> NFKBIA
    SPI1["SPI1"] -.biomarker for.-> NFKBIA
    GENES["GENES"] -.biomarker for.-> NFKBIA
    STXBP2["STXBP2"] -.biomarker for.-> NFKBIA
    FLNA["FLNA"] -.biomarker for.-> NFKBIA
    CTSD["CTSD"] -.biomarker for.-> NFKBIA

Outgoing (202)

Target	Relation	Type	Str
RELA	regulates	protein	0.90
NFKB	inhibits	protein	0.90
NF-kB signaling	participates_in	pathway	0.80
Neuroinflammation	regulates	disease	0.75
Inflammation	regulates	disease	0.75
NEUROINFLAMMATION	regulates	gene	0.70
Addiction	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Parkinson	regulates	disease	0.65
Ms	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	expressed_in	disease	0.65
Senescence	inhibits	disease	0.65
Hepatitis	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
JUNB	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
STXBP2	biomarker_for	gene	0.60
TRAF6	biomarker_for	gene	0.60
EGR2	biomarker_for	gene	0.60
SPI1	biomarker_for	gene	0.60
P38	biomarker_for	gene	0.60
CTSD	biomarker_for	gene	0.60
GFAP	regulates	gene	0.60
PINK1	regulates	gene	0.60
PGC1A	activates	gene	0.60
PER2	expressed_in	gene	0.60
LPL	activates	gene	0.60
CLOCK	activates	gene	0.60
SIRT1	activates	gene	0.60
PPARG	activates	gene	0.60
NLRP3	activates	gene	0.60
NR1D1	expressed_in	gene	0.60
NFKB1	activates	gene	0.60
SOD2	activates	gene	0.60
TNF	expressed_in	gene	0.60
C1Q	expressed_in	gene	0.60
MRC1	activates	gene	0.60

Incoming (124)

Source	Relation	Type	Str
PHF2	regulates	enzyme	0.95
Berberine	suppresses	compound	0.90
TRIM25	degrades	gene	0.90
TRIM25	mediates	gene	0.85
Scutellarein	downregulates	compound	0.85
NFKB	triggers_ubiquitination_dependent_degradation_by_TRIM25	protein	0.80
TRAF6	biomarker_for	gene	0.60
P38	biomarker_for	gene	0.60
CD4	biomarker_for	gene	0.60
EGR2	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
SPI1	biomarker_for	gene	0.60
STXBP2	biomarker_for	gene	0.60
FLNA	biomarker_for	gene	0.60
CTSD	biomarker_for	gene	0.60
JUNB	biomarker_for	gene	0.60
UBE3A	contributes_to	gene	0.60
CREB3	contributes_to	gene	0.60
PARKIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
PARK6	regulates	gene	0.60
MAPK8	contributes_to	gene	0.60
FASN	activates	gene	0.60
ICAM1	activates	gene	0.60
TREM2	activates	gene	0.60
TLR2	activates	gene	0.60
BCL2L1	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
TNFRSF1A	regulates	gene	0.60
STAT3	regulates	gene	0.60
IL1B	activates	gene	0.60
CD14	activates	gene	0.60
TNF	activates	gene	0.60
ITGAM	activates	gene	0.60
JUN	activates	gene	0.60
CXCL2	activates	gene	0.60
BMAL1	inhibits	gene	0.60
TP53	associated_with	gene	0.60
MYC	associated_with	gene	0.60
JUN	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
BNIP3	activates	gene	0.60
PPP5C	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	activates	gene	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
DUSP1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NFKBIA

Understanding Entity Pages

Summary

Wiki Pages (21)

NFKBIA Gene (NFKB Inhibitor Alpha)

neuroinflammation

fbxo38

NPY1R Gene

Geniposide for Alzheimer's disease - immune biomarker targeting and therapeutic potential

MYH2 Gene

ADCY9 Gene

FLNA Gene

FBXO38 Protein

Neurofilament Heavy Chain (NfH)

UBE3A

IκBα Protein

STXBP2 — Syntaxin Binding Protein 2

NF-κB p105 Protein

CALM2 Gene

NFKBIA Protein

Calmodulin 2 (CALM2)

NEFH Gene

NFKBIE Gene