concept

CBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

1Hypotheses

1Analyses

50Outgoing

19Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CBP
Key Genes/Proteins	ACAT1, ACLY, AMPK, APC, ATG, AXIN1
Related Pathways	apoptosis pathway, autophagy pathway
Linked Hypotheses	1 hypotheses

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CBP[CBP]
    CBP -->|activates| BDNF[BDNF]
    CBP -->|inhibits| SIRT1[SIRT1]
    CBP -->|participates in| epigenetic_regulation[epigenetic regulation]
    CBP -->|regulates| CREB[CREB]
    CBP -->|activates| NEURODEGENERATION[NEURODEGENERATION]
    CBP -->|regulates| NEURONS[NEURONS]
    CBP -->|activates| CREBBP[CREBBP]
    CBP -->|activates| EP300[EP300]
    ASTROCYTES[ASTROCYTES] -->|activates| CBP
    BECN1[BECN1] -->|activates| CBP
    CALCOCO2[CALCOCO2] -->|activates| CBP
    BDNF -->|regulates| CBP
    APC[APC] -->|regulates| CBP
    AXIN1[AXIN1] -->|regulates| CBP
    AXIN2[AXIN2] -->|regulates| CBP
    BRG1[BRG1] -->|regulates| CBP
    ACAT1[ACAT1] -->|activates| CBP
    AMPK[AMPK] -->|activates| CBP

Outgoing (88)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CBP	data_in	dataset_row	0.00
BDNF	activates	gene	0.90
SIRT1	inhibits	gene	0.70
EPIGENETIC MODIFICATION	regulates	phenotype	0.70
CREB	regulates	gene	0.70
epigenetic regulation	participates_in	pathway	0.70
NEURODEGENERATION	activates	phenotype	0.70
CREB	inhibits	gene	0.65
NEURONS	regulates	cell_type	0.65
BDNF	regulates	protein	0.64
CDH5	regulates	gene	0.60
CREBBP	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
EP300	regulates	gene	0.60
FOXM1	regulates	gene	0.60
MUC1	regulates	gene	0.60
MUC16	regulates	gene	0.60
SMARCA4	regulates	gene	0.60
CREB	interacts_with	gene	0.60
HSC70	activates	gene	0.60
SNARE	activates	gene	0.60
VPS34	activates	gene	0.60
CDH1	regulates	gene	0.60
GAPDH	activates	gene	0.60
HDAC6	activates	gene	0.60
HSPA8	activates	gene	0.60
KAT2A	activates	gene	0.60
KAT2B	activates	gene	0.60
KAT5	activates	gene	0.60
KAT8	activates	gene	0.60
LAMP2A	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
NBR1	activates	gene	0.60
NDP52	activates	gene	0.60
OPTN	activates	gene	0.60
PIK3C3	activates	gene	0.60
RB1	activates	gene	0.60
RB1CC1	activates	gene	0.60
RUBCN	activates	gene	0.60
SIRT1	activates	gene	0.60
SNAP29	activates	gene	0.60
SQSTM1	activates	gene	0.60
STX17	activates	gene	0.60
TFEB	activates	gene	0.60
TP53	activates	gene	0.60
ULK1	activates	gene	0.60
VAMP8	activates	gene	0.60
WIPI2	activates	gene	0.60
HDAC1	regulates	gene	0.60

Incoming (19)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CBP	data_in	dataset_row	0.00
ASTROCYTES	activates	cell_type	0.70
BECN1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
BDNF	regulates	gene	0.60
ACAT1	activates	gene	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
rapamycin	targets	drug	0.60
APC	regulates	gene	0.60
AXIN1	regulates	gene	0.60
AXIN2	regulates	gene	0.60
BRG1	regulates	gene	0.60
AMPK	regulates	gene	0.60
ACLY	activates	gene	0.55
BDNF	activates	gene	0.55
RAPAMYCIN	associated_with	drug	0.45
PARKINSON	associated_with	disease	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p300/CBP-dependent K280 acetylation nucleates pathogenic tau	0.455	neurodegeneration	Which specific post-translational modifi

Mentioning Analyses (1)

Scientific analyses that reference this entity

What neural circuits encode and maintain multi-generational migratory route memo

spatial memory | 2026-04-08 | 7 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The paper describes memory-based migration routes maintained across generations

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning CBP in their description or question text

No additional research found

CBP