concept

EPO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

133Connections

2Hypotheses

9Analyses

50Outgoing

37Incoming

Summary

EPO is a concept in neurodegeneration research. Key relationships include: regulates, activates, therapeutic target. Associated with ALS, Als, Asthma. Connected to 87 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	EPO
Related Diseases	Als, Leukemia, Ischemia, Ms, Stroke
Related Pathways	erythropoiesis
Linked Hypotheses	5 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    EPO["EPO"]
    EPO -->|"regulates"| erythropoiesis["erythropoiesis"]
    EPO -->|"regulates"| Als["Als"]
    EPO -->|"activates"| Leukemia["Leukemia"]
    EPO -->|"activates"| Ischemia["Ischemia"]
    EPO -->|"activates"| Ms["Ms"]
    EPO -->|"activates"| Stroke["Stroke"]
    EPO -->|"activates"| Tumor["Tumor"]
    EPO -->|"activates"| Cardiovascular["Cardiovascular"]
    EPO -->|"regulates"| ALS["ALS"]
    FOS["FOS"] -->|"activates"| EPO
    VHL["VHL"] -->|"activates"| EPO
    BAX["BAX"] -->|"activates"| EPO
    ERK["ERK"] -->|"activates"| EPO
    FGF2["FGF2"] -->|"regulates"| EPO
    TLR4["TLR4"] -->|"regulates"| EPO
    PI3K["PI3K"] -->|"regulates"| EPO
    ISG15["ISG15"] -->|"regulates"| EPO
    EPOR["EPOR"] -->|"regulates"| EPO
    CXCL10["CXCL10"] -->|"regulates"| EPO

Outgoing (96)

Target	Relation	Type	Str
erythropoiesis	regulates	biological_process	0.80
TfRMAb-EPO	associated_with	drug	0.70
Als	regulates	disease	0.65
Leukemia	activates	disease	0.65
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Stroke	activates	disease	0.65
Tumor	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Als	activates	disease	0.65
ALS	regulates	disease	0.65
Asthma	regulates	disease	0.65
Pneumonia	regulates	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Renal Cell Carcinoma	therapeutic_target	disease	0.65
Depression	activates	disease	0.65
Anxiety	activates	disease	0.65
NEUROGENESIS	regulates	phenotype	0.65
C-FOS	activates	gene	0.60
CAT	activates	gene	0.60
JUND	activates	gene	0.60
C-JUN	activates	gene	0.60
JUN	activates	gene	0.60
VEGF	activates	gene	0.60
TNF	activates	gene	0.60
IL-6	activates	gene	0.60
VEGFA	activates	gene	0.60
TNF-Α	activates	gene	0.60
BCL-2	activates	gene	0.60
Angiogenesis	activates	pathway	0.60
Blood-Brain Barrier	activates	pathway	0.60
FGF8	regulates	gene	0.60
AKT	regulates	gene	0.60
S100A8	regulates	gene	0.60
P38	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
ERK	regulates	gene	0.60
NAMPT	regulates	gene	0.60
CSF2	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
STAT1	regulates	gene	0.60
BCL-2	regulates	gene	0.60
Akt	regulates	pathway	0.60
Mapk	regulates	pathway	0.60
Pi3K	regulates	pathway	0.60

Incoming (37)

Source	Relation	Type	Str
TLR4	regulates	gene	0.70
PI3K	regulates	gene	0.70
AKT	regulates	gene	0.70
FOS	activates	gene	0.60
VHL	activates	gene	0.60
BAX	activates	gene	0.60
ERK	activates	gene	0.60
FGF2	regulates	gene	0.60
ISG15	regulates	gene	0.60
EPOR	regulates	gene	0.60
CXCL10	regulates	gene	0.60
JAK2	activates	gene	0.60
CSF2RA	regulates	gene	0.60
ERK	regulates	gene	0.60
S100A8	regulates	gene	0.60
P38	regulates	gene	0.60
CSF2	regulates	gene	0.60
FGF8	regulates	gene	0.60
TSLP	associated_with	gene	0.60
FOS	regulates	gene	0.60
NF-KB	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
PIEZO1	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
VHL	therapeutic_target	gene	0.60
LGALS9	regulates	gene	0.60
STAT1	regulates	gene	0.60
MAPK	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
BCL-2	regulates	gene	0.60
AND	regulates	gene	0.60
GENES	regulates	gene	0.60
NAMPT	regulates	gene	0.60
ANXIETY	activates	gene	0.60
CD31	activates	gene	0.60
DENTATE GYRUS	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
EPO Set Point Calibration Hypothesis	0.572	endocrinology	Does TRT-induced erythrocytosis actually
Metabolic Switch Targeting for A1→A2 Repolarization	0.481	neurodegeneration	Astrocyte reactivity subtypes in neurode

Mentioning Analyses (9)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352]	Pesce NA, Seminara G, Giarrusso G, Tomas	Adv Biol (Weinh)	2026	1
Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285]	Fang M, Zhou Y, He K, Lu Y, Tao F, Huang	Mol Neurobiol	2025	1
Hexokinase 2-mediated metabolic stress and inflammation burden of liver macropha [PMID:40014451]	Li J, Chen X, Song S, Jiang W, Geng T, W	Cell Rep	2025	1
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014]	Fontana F, Giannitti G, Marchesi S, Limo	Int J Biol Sci	2024	1
Metabolic phenotype of bladder cancer. [PMID:26975021]	Massari F, Ciccarese C, Santoni M, Iacov	Cancer Treat Rev	2016	1
Aryl hydrocarbon receptor impairs HK2-controlled flux of the hexosamine biosynth [PMID:40582563]	Li S, Zhu J, Song J, Yang L, Gong Y et a	J Adv Res	2026	0
HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis [PMID:41023273]	Mitchell CD, Morris CA, Wild M, Cunningh	Acta Pharmacol Sin	2026	0
Hypoxia-Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via t [PMID:41229334]	Zhu XH, Hou JW, Lv ZY, Sun MH, Zhang XY	Kaohsiung J Med Sci	2026	0
Granzyme B knockdown inhibits NLRP3-mediated pyroptosis and the JAK2/STAT3 signa [PMID:41447776]	Wang M, Chen D, Zhang D, Han H, Xie M et	Tissue Cell	2026	0
Suoquan Yishen formula attenuates ectopic lipid deposition in diabetic kidney di [PMID:41461331]	Wang J, Lin N, Li X, Ma T, Yuan Y et al.	J Ethnopharmacol	2026	0
Yi-Shen-Hua-Shi granules ameliorate renal injury via PPARγ-Klotho-mediated metab [PMID:41475627]	Gao HZ, Sun LM, Hu D, Li J, Chen CL et a	J Ethnopharmacol	2026	0
Targeting glycolysis in prostate cancer: Molecular mechanisms and therapeutic ad [PMID:41548699]	Zhang J, Zhang T, Song D, Xu D	Biochim Biophys Acta Rev Cance	2026	0
Bisphenol A Promotes Ovarian Cancer Proliferation and Migration through the HK2/ [PMID:41885081]	Xie X, Zhang Y, Li Y, Yan Q, Dong J et a	J Agric Food Chem	2026	0
Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: [PMID:41936633]	Tang Y, Wang S, Wang Y, Zhang T, Liu Y e	Histochem Cell Biol	2026	0
SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic [PMID:41945160]	Jian Y, Zeng Y, Wang Z, Zhou X, Zhang H	Apoptosis	2026	0
Nuclear hexokinase 2 couples hyperglycemia to MYC-driven glycolytic and stemness [PMID:41951587]	Liu S, Liu X, Liu G, Wang Z, Li C et al.	Cell Death Dis	2026	0
Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reduc [PMID:41958068]	Gong D, Chen X, Dong Z, Chen H, Liu Z	Ren Fail	2026	0
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates [PMID:41960638]	Lin W, Dong C, Jiang Q, Lou Y, Wang L et	Redox Rep	2026	0
Metformin treatment impairs the adenine nucleotide translocator activity and ene [PMID:41963519]	de Bari L, Caratozzolo MF, Petrosillo G,	Sci Rep	2026	0
Duzhong-Gegen formula ameliorated hyperuricemia by enhancing renal uric acid exc [PMID:41905095]	Wang L, Gan Y, Huang J, Long L, Li S, Wa	Phytomedicine : international	2026	0

EPO

Understanding Entity Pages

Summary

Wiki Pages (20)

JAK-STAT Signaling Pathway in Neurodegeneration

epas1-protein

JAK-STAT and Cytokine Signaling in 4R-Tauopathies

Lauren Shore

Hyperbaric Oxygen Therapy for Neurodegeneration

Pathway Diagram

Outgoing (96)

Incoming (37)

Targeting Hypotheses (2)

Mentioning Analyses (9)

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

How does pericyte senescence mechanistically promote glioma cell growth and inva

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

Human connectome alterations and network-level dysfunction in Alzheimer disease

Related Papers (20)

EPO

Understanding Entity Pages

Summary

Wiki Pages (20)

JAK-STAT Signaling Pathway in Neurodegeneration

epas1-protein

JAK-STAT and Cytokine Signaling in 4R-Tauopathies

Lauren Shore

Hyperbaric Oxygen Therapy for Neurodegeneration

Hypoxia Response Pathway

HIF1AN — Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor

HIF/Hypoxia Signaling in Parkinson's Disease

HIF/Hypoxia Signaling in Parkinson's Disease

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

Hypoxia Neuroprotection in Sporadic Parkinson's Disease

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

JAK2 Gene - Janus Kinase 2

EGLN1 — Egl-9 Family Prolyl Hydroxylase 1

PD EGFR Signaling Therapy Companies

HIF Signaling in Neurodegeneration

Erythropoietin Signaling Pathway in Neurodegeneration

AD FGF/FGFR Signaling Companies

STAT5A Gene

EPAS1 Gene

Pathway Diagram

Outgoing (96)

Incoming (37)

Targeting Hypotheses (2)

Mentioning Analyses (9)

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

How does pericyte senescence mechanistically promote glioma cell growth and inva

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

Human connectome alterations and network-level dysfunction in Alzheimer disease

Related Papers (20)