concept

PTN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

116Connections

6Hypotheses

1Analyses

50Outgoing

37Incoming

0Experiments

1Debates

Summary

PTN is a concept in neurodegeneration research. Key relationships include: expressed in, interacts with, implicated in. Associated with AD, ALI, ALS. Connected to 74 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PTN
Key Genes/Proteins	AKT, ALZHEIMER, AMYLOID
Related Diseases	AD, ALI, Als, ALS, Alzheimer
Related Pathways	Akt, Amyloid
Linked Hypotheses	5 hypotheses

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PTN["PTN"]
    PTN -->|"interacts"| PTPRZ1["PTPRZ1"]
    PTN -->|"activates"| adult_hippocampal_neurogenesis["adult hippocampal neurogenesis"]
    PTN -.protects against.-> cognitive_impairment["cognitive impairment"]
    PTN -.protects against.-> memory_deficits["memory deficits"]
    PTN -->|"activates"| memory["memory"]
    PTN -.biomarker for.-> Alzheimer["Alzheimer"]
    PTN -->|"expressed in"| ALS["ALS"]
    PTN -.biomarker for.-> Amyloid["Amyloid"]
    PTN -->|"interacts"| AMYLOID["AMYLOID"]
    PTN -->|"expressed in"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    PTN -->|"expressed in"| JUN["JUN"]
    aging["aging"] -->|"regulates"| PTN
    AMYLOID -.biomarker for.-> PTN
    ALZHEIMER_S_DISEASE -.biomarker for.-> PTN
    ALZHEIMER["ALZHEIMER"] -.biomarker for.-> PTN
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| PTN
    NTN1["NTN1"] -->|"interacts"| PTN
    TARDBP["TARDBP"] -->|"interacts"| PTN
    SNRNP70["SNRNP70"] -->|"interacts"| PTN
    AND["AND"] -->|"interacts"| PTN

Outgoing (79)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.85
ALZHEIMER'S DISEASE	associated_with	entity	0.80
memory	activates	process	0.70
cognitive impairment	protects_against	disease	0.70
adult hippocampal neurogenesis	activates	process	0.70
PTPRZ1	interacts_with	protein	0.70
memory deficits	protects_against	process	0.70
Cancer	expressed_in	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Ms	biomarker_for	disease	0.65
Depression	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
GPNMB	associated_with	gene	0.60
AMYLOID	biomarker_for	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
CD4	expressed_in	gene	0.60
AND	inhibits	gene	0.60
Amyloid	biomarker_for	pathway	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
DNA	interacts_with	gene	0.60
NTN1	interacts_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
SNRNP70	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
NTN3	interacts_with	gene	0.60
Protein Aggregation	expressed_in	pathway	0.60
Amyloid	interacts_with	pathway	0.60
Endocytosis	expressed_in	pathway	0.60
Exocytosis	expressed_in	pathway	0.60
Complement	expressed_in	pathway	0.60
senescence	participates_in	pathway	0.60
cancer	associated_with	disease	0.60
apoptosis pathway	participates_in	pathway	0.60
STAT3	inhibits	gene	0.60
STAT3	activates	gene	0.60
TAR	interacts_with	gene	0.60
neurons	expressed_in	cell_type	0.60
pericytes	expressed_in	cell_type	0.60
blood-brain barrier	participates_in	pathway	0.60

Incoming (37)

Source	Relation	Type	Str
aging	regulates	process	0.70
PTPRZ1	inhibits	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
ROBO1	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
TAU	interacts_with	gene	0.60
CSF1	activates	gene	0.60
CSF1R	activates	gene	0.60
FGF1	activates	gene	0.60
FGFR2	activates	gene	0.60
APP	expressed_in	gene	0.60
PS1	expressed_in	gene	0.60
JNK	activates	gene	0.60
MAPK	activates	gene	0.60
GPNMB	associated_with	gene	0.60
AMYLOID	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
VGF	associated_with	gene	0.60
NTN1	associated_with	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NPTX2	associated_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
NTN1	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
SNRNP70	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
RNA	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
AMYLOID	interacts_with	gene	0.60
NTN3	interacts_with	gene	0.60
AKT	activates	gene	0.60
GPNMB	interacts_with	gene	0.60
NPTX2	interacts_with	gene	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TBK1-OPTN-p62 selective autophagy failure across ALS, FTD, a	0.776	multi	Cross-disease neurodegeneration mechanis
TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle	0.772	neurodegeneration	How do different organelle-specific auto
OPTN/TBK1 mutations create selective vulnerability by blocki	0.670	neurodegeneration	What are the neuron-specific effects of
ALS-Linked OPTN/TBK1 Mutations Impair Phosphorylation Cascad	0.648	neurodegeneration	How do pathological stress granules in n
TREM2 Agonism to Redirect Microglia from Synaptic Pruning to	0.521	neurodegeneration	How do ALS-associated OPTN mutations mec

Loss of pericyte-derived pleiotrophin is a key disease-modif	0.510	neurodegeneration	Does pericyte senescence drive BBB break

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. [PMID:33168089]	Quinn PMJ, Moreira PI, Ambrósio AF, Alve	Acta neuropathologica communic	2020
DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899]	Merlo, Cuchillo-Ibañez, Parlato, Ra	Neural plasticity	2018
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899]	Unknown	Neural Plast	2016
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. [PMID:25803835]	Unknown	Nature neuroscience	2015
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. [PMID:25611507]	["Pickrell Alicia M", "Youle Richard J"]	Neuron	2015
Neurodegeneration. [PMID:12938729]	Burgunder	IUBMB life	2004
Neurodegeneration. [PMID:12938729]	Unknown	IUBMB Life	2003

Debates (1)

Multi-agent debates referencing this entity

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning PTN in their description or question text

Loss of pericyte-derived pleiotrophin is a key disease-modifying consequence of

Score: 0.510 · neurodegeneration · 2026-04-25

The major pathological effect of pericyte senescence may be failure of a protective trophic secretome, especially pleiot

PTN

Understanding Entity Pages

Summary

Wiki Pages (5)

OPTN Protein (Optineurin)

OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal Chain

OPTN Protein (Optineurin)

OPTN — Optineurin

OPTN Protein (Optineurin)

Pathway Diagram

Outgoing (79)

Incoming (37)

Targeting Hypotheses (6)

Mentioning Analyses (1)

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

Experiments (0)

Related Papers (12)

Debates (1)

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d

Related Research

Loss of pericyte-derived pleiotrophin is a key disease-modifying consequence of