SciDEX — IL-17

graph TD
    IL_17["IL-17"]
    IL_17 -->|"mediates"| Myeloid_Cell_Immune_Response["Myeloid Cell Immune Response"]
    IL_17 -->|"mediates"| Neuroinflammation["Neuroinflammation"]
    IL_17 -->|"promotes"| hidradenitis_suppurativa["hidradenitis suppurativa"]
    IL_17 -->|"co_expressed_with"| IL_1["IL-1"]
    IL_17 -.biomarker for.-> Rheumatoid_Arthritis["Rheumatoid Arthritis"]
    IL_17 -->|"activates"| TNF["TNF"]
    IL_17 -->|"inhibits"| IL_6["IL-6"]
    Neutrophils["Neutrophils"] -->|"expressed in"| IL_17
    Microglia["Microglia"] -->|"expressed in"| IL_17
    APOPTOSIS["APOPTOSIS"] -->|"activates"| IL_17
    CYTOKINES["CYTOKINES"] -->|"inhibits"| IL_17
    CASP3["CASP3"] -->|"activates"| IL_17
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IL_17

Outgoing (349)

Target	Relation	Type	Str
Myeloid Cell Immune Response	mediates	process	0.85
Neuroinflammation	mediates	process	0.85
Cognitive Impairment	associated_with	phenotype	0.85
hidradenitis suppurativa	promotes	disease	0.85
Autoimmune Diseases	associated_with	disease	0.80
IL-1	co_expressed_with	protein	0.80
Rheumatoid Arthritis	biomarker_for	disease	0.80
INFLAMMATION	promotes	process	0.80
MICROGLIA	upregulates	cell_type	0.80
skeletal muscle inflammation	mediates	process	0.70
TNF	activates	gene	0.65
IL-6	inhibits	gene	0.65
TNF	inhibits	gene	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Parkinson	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Autoimmune	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Als	regulates	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Stroke	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Als	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Ferroptosis	activates	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Vascular Dementia	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Cirrhosis	activates	disease	0.65

Incoming (243)

Source	Relation	Type	Str
Neutrophils	expressed_in	cell_type	0.85
Microglia	expressed_in	cell_type	0.85
TRIPTOLIDE	inhibits	compound	0.80
blood-brain barrier permeability	activates	process	0.70
INFLAMMATION	regulates	gene	0.60
TGFB1	regulates	gene	0.60
FOXP3	regulates	gene	0.60
CD4	regulates	gene	0.60
PSME3	associated_with	gene	0.60
BAD	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
BID	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
PPP1CB	associated_with	gene	0.60
TNF	activates	gene	0.60
NF-ΚB	activates	gene	0.60
MMP9	associated_with	gene	0.60
GENES	activates	gene	0.60
S100A8	activates	gene	0.60
S100A9	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
CYTOKINES	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
IL-1	interacts_with	gene	0.60
IL-6	associated_with	gene	0.60
JAK	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
PSME3	therapeutic_target	gene	0.60
BAD	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
LAMP2	therapeutic_target	gene	0.60
BID	therapeutic_target	gene	0.60
TLR2	associated_with	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
IL-1	associated_with	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
CXCL8	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
MMP9	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AMYLOID	activates	gene	0.60
IL-1	inhibits	gene	0.60
CASP3	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
STROKE	expressed_in	gene	0.60

Name	IL-17
Key Genes/Proteins	IL-1, TNF, IL-6
Related Diseases	Cognitive Impairment, hidradenitis suppurativa, Autoimmune Diseases, Rheumatoid Arthritis

IL-17

Understanding Entity Pages

Wiki Pages (20)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

neuroinflammation

Multiple Sclerosis (MS)

NF-kB Signaling Pathway in Neurodegeneration

Psychobiotic Therapy for Neurodegenerative Diseases

Pathway Diagram

Outgoing (349)

Incoming (243)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)

IL-17

Understanding Entity Pages

Wiki Pages (20)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

neuroinflammation

Multiple Sclerosis (MS)

NF-kB Signaling Pathway in Neurodegeneration

Psychobiotic Therapy for Neurodegenerative Diseases

Neuroinflammation in Amyotrophic Lateral Sclerosis

Neuroinflammation in Parkinson's Disease

Adaptive Immunity in Neurodegeneration

Demyelination

Section 132: Advanced Systems Immunology and Network Pharmacology in CBS/PSP

Neuroinflammation in Parkinson's Disease

IL17C Gene

singapore-asia-pacific-neurodegeneration

peripheral-immune-infiltration

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

IL25 (Interleukin 25)

Peripheral Immune System in Parkinson's Disease

FC Gamma Receptor IIIA

IL20 (Interleukin 20)

RORC Gene

Pathway Diagram

Outgoing (349)

Incoming (243)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)