concept

GFP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GFP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1023Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

GFP is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with AD, ALI, ALS. Connected to 429 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameGFP
Key Genes/ProteinsLC3, AUTOPHAGY, MTOR, AKT
Related DiseasesTumor, Aging, Als, Infection
Related PathwaysAutophagy, Mtor, oxidative stress response, autophagy pathway, ubiquitin-proteasome

Wiki Pages (20)

Knowledge base pages for this entity

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

mechanism · 7227 words

Microglial Cells — Cell Type Hierarchy

cell · 5150 words

Autophagy Mechanisms

mechanism · 4866 words

proteasome-ubiquitin-system-dysfunction-parkinsons

general · 3977 words

Astrocytes

cell · 3974 words

Pathway Diagram

graph TD
    GFP["GFP"]
    GFP -->|"expressed in"| microglia["microglia"]
    GFP -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    GFP -->|"interacts"| ALS["ALS"]
    GFP -->|"interacts"| Dementia["Dementia"]
    GFP -->|"activates"| Tumor["Tumor"]
    GFP -->|"degrades"| Aging["Aging"]
    GFP -->|"degrades"| Cardiovascular["Cardiovascular"]
    GFP -->|"inhibits"| Inflammation["Inflammation"]
    C9ORF72["C9ORF72"] -->|"interacts"| GFP
    LC3["LC3"] -->|"interacts"| GFP
    P62["P62"] -->|"interacts"| GFP
    FUS["FUS"] -->|"interacts"| GFP
    UBIQUITIN["UBIQUITIN"] -->|"interacts"| GFP
    SQSTM1["SQSTM1"] -->|"interacts"| GFP
    TRIM21["TRIM21"] -->|"interacts"| GFP
    OPTN["OPTN"] -->|"interacts"| GFP
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"regulates"| GFP
    ACTB["ACTB"] -->|"interacts"| GFP

Outgoing (710)

TargetRelationTypeStr
LC3associated_withgene1.00
AUTOPHAGYassociated_withgene1.00
Autophagyassociated_withpathway1.00
AUTOPHAGYactivatesgene1.00
Autophagyactivatespathway1.00

Incoming (313)

SourceRelationTypeStr
rapamycintargetsdrug0.80
SQSTM1associated_withgene0.70
BECN1associated_withgene0.70
BECN1activatesgene0.70
CALCOCO2regulatesgene0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found