DEPTOR

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

DEP domain-containing mTOR interacting protein - endogenous inhibitor of mTORC1 and mTORC2 with roles in autophagy, cellular metabolism, and neurodegenerative diseases

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flowchart TD
    DEPTOR["DEPTOR<br/>mTOR Inhibitor"]
    
    MTOR["MTOR<br/>Mechanistic Target<br/>of Rapamycin"]
    RICTOR["RICTOR<br/>mTORC2 Component"]
    MLST8["MLST8<br/>mTOR Complex<br/>Component"]
    
    PI3K["PI3K/AKT<br/>Pathway"]
    MAPK["MAPK<br/>Signaling"]
    
    AUTOPHAGY["Autophagy<br/>Pathway"]
    FIP200["FIP200<br/>Autophagy<br/>Initiator"]
    AMBRA1["AMBRA1<br/>Autophagy<br/>Regulator"]
    PIK3C3["PIK3C3<br/>Autophagy<br/>Kinase"]
    
    OXPHOS["Oxidative<br/>Phosphorylation"]
    HSPA5["HSPA5<br/>ER Stress<br/>Response"]
    
    ALS["ALS<br/>Motor Neuron<br/>Disease"]
    MS["Multiple<br/>Sclerosis"]
    FIBROSIS["Fibrosis"]
    
    NEURODEGENERATION["Neurodegeneration"]
    
    DEPTOR --|"inhibits"|--> MTOR
    DEPTOR --|"interacts"|--> RICTOR
    DEPTOR --|"interacts"|--> MLST8
    
    MTOR --|"regulates"|--> PI3K
    MTOR --|"controls"|--> MAPK
    MTOR --|"inhibits"|--> AUTOPHAGY
    
    AUTOPHAGY --|"involves"|--> FIP200
    AUTOPHAGY --|"involves"|--> AMBRA1
    AUTOPHAGY --|"involves"|--> PIK3C3
    
    MTOR --|"regulates"|--> OXPHOS
    OXPHOS --|"triggers"|--> HSPA5
    
    DEPTOR --|"regulates"|--> ALS
    DEPTOR --|"interacts"|--> MS
    DEPTOR --|"regulates"|--> FIBROSIS
    
    ALS --|"contributes"|--> NEURODEGENERATION
    MS --|"contributes"|--> NEURODEGENERATION
    HSPA5 --|"promotes"|--> NEURODEGENERATION
    
    style DEPTOR fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style FIP200 fill:#1b5e20
    style AMBRA1 fill:#1b5e20
    style PIK3C3 fill:#1b5e20
    style MTOR fill:#4a1a6b
    style RICTOR fill:#4a1a6b
    style MLST8 fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style FIBROSIS fill:#ef5350
    style NEURODEGENERATION fill:#5d4400
    style HSPA5 fill:#ef5350