gene

C-MYC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C-MYC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

275Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	MYC
Full Name	MYC Proto-Oncogene, BHLH Transcription Factor
Aliases	c-Myc, bHLHe39
Chromosome	8q24.21
Function	Master transcription factor for cell proliferation. In neurodegeneration, reactivation linked to aberrant cell cycle re-entry.
Primary Expression	Ubiquitous; low in mature neurons
Molecular Weight	48.8 kDa
Gene Type	Protein-coding
Pathways	PI3K-AKT-mTOR, Wnt/beta-catenin, Cell cycle regulation
GeneCards	MYC
Human Protein Atlas	MYC
Associated Diseases	Pluripotency, Tumor
Interactions	Actin, AGING, AKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	267 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: C-MYC — AlphaFold P01106 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    C_MYC["C-MYC"] -->|"activates"| Pluripotency["Pluripotency"]
    C_MYC["C-MYC"] -->|"activates"| Carcinoma["Carcinoma"]
    C_MYC["C-MYC"] -->|"activates"| Cancer["Cancer"]
    C_MYC["C-MYC"] -->|"therapeutic target"| Tumor["Tumor"]
    C_MYC["C-MYC"] -->|"regulates"| Cancer_1["Cancer"]
    C_MYC["C-MYC"] -->|"activates"| Als["Als"]
    LDHA["LDHA"] -->|"activates"| C_MYC["C-MYC"]
    MYC["MYC"] -->|"activates"| C_MYC["C-MYC"]
    AND["AND"] -->|"activates"| C_MYC["C-MYC"]
    MYC_2["MYC"] -.->|"inhibits"| C_MYC["C-MYC"]
    style C_MYC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (186)

Target	Relation	Type	Str
Pluripotency	activates	phenotype	0.90
Pluripotency	associated_with	phenotype	0.90
Ms	inhibits	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	protects_against	disease	0.65
Alzheimer	activates	disease	0.65
Fibrosis	activates	disease	0.65
Aging	regulates	disease	0.65
Cirrhosis	activates	disease	0.65
Senescence	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Glioblastoma	inhibits	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
Als	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Obesity	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Ms	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	interacts_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
CANCER	expressed_in	gene	0.60
AXIN2	regulates	gene	0.60
CYCLIN D1	regulates	gene	0.60
Wnt	regulates	pathway	0.60
KAT2A	interacts_with	gene	0.60
YAP	activates	gene	0.60
MARK4	activates	gene	0.60
HIPPO	activates	gene	0.60
Tgf-Β	associated_with	pathway	0.60

Incoming (89)

Source	Relation	Type	Str
RNA polymerase II	activates	protein	0.90
ZNF746	stabilizes	gene	0.80
MTOR	regulates	gene	0.70
MTOR	regulates	gene	0.70
AKT	regulates	gene	0.70
MTOR	enhances	gene	0.70
MTOR	enhances	gene	0.70
RNA	activates	gene	0.60
CDKN2B-AS1	activates	gene	0.60
PTEN	inhibits	gene	0.60
AHR	regulates	gene	0.60
APP	activates	gene	0.60
LDHA	activates	gene	0.60
MYC	activates	gene	0.60
AND	activates	gene	0.60
MYC	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	inhibits	gene	0.60
SRC	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
DNA	interacts_with	gene	0.60
MYC	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
PI3K	activates	gene	0.60
AKT1	activates	gene	0.60
ERK1	activates	gene	0.60
AGING	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
LNCRNA	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
PD-L1	inhibits	gene	0.60
GLIOBLASTOMA	inhibits	gene	0.60
CD8	activates	gene	0.60
GBM	inhibits	gene	0.60
HDAC	inhibits	gene	0.60
GENES	activates	gene	0.60
AGING	biomarker_for	gene	0.60
KLF4	biomarker_for	gene	0.60
SOX2	biomarker_for	gene	0.60
NEURODEGENERATION	activates	gene	0.60
OCT4	biomarker_for	gene	0.60
MYC	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
DNMT3A	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MYC	regulates	gene	0.60
AND	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity