concept

FTLD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FTLD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

581Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

1Experiments

Summary

FTLD is a concept in neurodegeneration research. Key relationships include: associated with, biomarker for, interacts with. Associated with Aging, Als, Alzheimer. Connected to 123 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	FTLD
Key Genes/Proteins	TDP-43, MAPT, TARDBP, SQSTM1, UBQLN2
Related Diseases	Als, frontotemporal dementia, Amyotrophic Lateral Sclerosis, neurodegeneration, ALS
Related Pathways	oxidative stress response

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FTLD["FTLD"]
    FTLD -->|"interacts"| Inflammation["Inflammation"]
    FTLD -->|"interacts"| Ms["Ms"]
    FTLD -->|"expressed in"| Alzheimer["Alzheimer"]
    FTLD -->|"phosphorylates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    FTLD -->|"causes"| Aging["Aging"]
    FTLD -->|"interacts"| INFLAMMATION["INFLAMMATION"]
    FTLD -->|"interacts"| ULK1["ULK1"]
    FTLD -.protects against.-> C9ORF72["C9ORF72"]
    FTLD -.protects against.-> HEXANUCLEOTIDE_REPEAT_EXPANSIO["HEXANUCLEOTIDE REPEAT EXPANSIONS"]
    FTLD -.protects against.-> GRN["GRN"]
    FIP200["FIP200"] -->|"interacts"| FTLD
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| FTLD
    APOE4["APOE4"] -->|"expressed in"| FTLD
    DNA["DNA"] -->|"expressed in"| FTLD
    FUS["FUS"] -->|"causes"| FTLD
    ALZHEIMER["ALZHEIMER"] -->|"expressed in"| FTLD
    AND["AND"] -->|"phosphorylates"| FTLD
    TARDBP["TARDBP"] -->|"expressed in"| FTLD
    ALS["ALS"] -->|"phosphorylates"| FTLD

Outgoing (437)

Target	Relation	Type	Str
Als	associated_with	disease	0.95
oxidative stress response	participates_in	pathway	0.90
frontotemporal dementia	interacts_with	disease	0.90
neurons	expressed_in	cell_type	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
neurodegeneration	associated_with	disease	0.80
ALS	interacts_with	disease	0.80
frontotemporal dementia	causes	disease	0.80
neurodegeneration	interacts_with	disease	0.80
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.80
ALS	associated_with	gene	0.80
Neurodegeneration	biomarker_for	disease	0.75
NEURODEGENERATIVE DISEASES	associated_with	gene	0.70
NEURODEGENERATION	biomarker_for	gene	0.70
frontotemporal dementia	associated_with	disease	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Alzheimer's disease	interacts_with	disease	0.70
neurodegeneration	regulates	disease	0.70
frontotemporal dementia	regulates	disease	0.70
cortex	expressed_in	brain_region	0.70
RNA	regulates	gene	0.70
frontotemporal dementia	biomarker_for	disease	0.70
GRN	regulates	gene	0.70
TDP43	interacts_with	gene	0.70
Ms	associated_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Aging	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	phosphorylates	disease	0.65
Aging	causes	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Als	contributes_to	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Dementia	biomarker_for	disease	0.65
Dementia	regulates	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Dementia	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Neurodegeneration	causes	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Huntington	associated_with	disease	0.65

Incoming (144)

Source	Relation	Type	Str
TDP-43	associated_with	protein	0.95
ALS	associated_with	gene	0.90
ALS	coexists_with	disease	0.80
MAPT	implicated_in	gene	0.80
TARDBP	implicated_in	gene	0.80
SQSTM1	implicated_in	gene	0.80
UBQLN2	implicated_in	gene	0.80
OPTN	implicated_in	gene	0.80
GRN	implicated_in	gene	0.80
C9ORF72	implicated_in	gene	0.80
ALS	interacts_with	gene	0.80
DNA	interacts_with	gene	0.80
ALS	regulates	gene	0.70
TARDBP	associated_with	gene	0.60
NFE2L2	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
FIP200	interacts_with	gene	0.60
SMCR8	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
APOE4	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
C9ORF72	associated_with	gene	0.60
FUS	causes	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
TARDBP	expressed_in	gene	0.60
ALS	phosphorylates	gene	0.60
SOD1	causes	gene	0.60
GENES	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
AND	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
NEURON	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
GJA1	activates	gene	0.60
PROGRANULIN	causes	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
TAF15	associated_with	gene	0.60
FUS	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
ATXN2	causes	gene	0.60
HUNTINGTON	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms enable functional recovery and muscle re-innervation a

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.658

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

neurodegeneration | 2026-04-07 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FTLD

Understanding Entity Pages

Summary

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

primary-progressive-aphasia

Atypical Parkinsonism

Corticobasal Degeneration (CBD)

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

CBS/PSP Clinical Trials Guide

ftd-tdp-pathology

University of Heidelberg

CSF Neurofilament Light Chain (NfL) in Neurodegeneration

TDP-43 Proteinopathy

Tauopathies

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Experiment Prioritization Index — Neurodegeneration

Synaptic Dysfunction in Neurodegeneration

Frontotemporal Dementia

Metal Homeostasis Dysfunction Comparison Across Neurodegenerative Diseases

Beta-Amyloid 42/40 Ratio - Biomarker