concept

KRAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KRAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

968Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

KRAS is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with AD, ARM, Aging. Connected to 440 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	KRAS
Key Genes/Proteins	CANCER, TP53
Related Diseases	Cancer, Tumor, Als, Carcinoma

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    KRAS["KRAS"]
    KRAS -->|"inhibits"| Cancer["Cancer"]
    KRAS -->|"target for"| Carcinoma["Carcinoma"]
    KRAS -->|"inhibits"| Tumor["Tumor"]
    KRAS -->|"activates"| Als["Als"]
    KRAS -->|"activates"| Ms["Ms"]
    PRMT1["PRMT1"] -->|"inhibits"| KRAS
    VDAC1["VDAC1"] -->|"expressed in"| KRAS
    DRP1["DRP1"] -->|"activates"| KRAS
    DNM1L["DNM1L"] -->|"activates"| KRAS
    GABARAP["GABARAP"] -->|"activates"| KRAS
    WIPI2["WIPI2"] -->|"activates"| KRAS
    P38["P38"] -->|"activates"| KRAS
    BRAF["BRAF"] -->|"regulates"| KRAS
    AKT["AKT"] -->|"activates"| KRAS
    NFE2L2["NFE2L2"] -->|"activates"| KRAS

Outgoing (672)

Target	Relation	Type	Str
Cancer	inhibits	disease	1.00
Tumor	inhibits	disease	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Als	activates	disease	1.00
Carcinoma	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	activates	gene	1.00
CANCER	inhibits	gene	1.00
CANCER	associated_with	gene	1.00
Cancer	associated_with	disease	1.00
TP53	associated_with	gene	1.00
Colorectal Cancer	activates	disease	1.00
Tumor	associated_with	disease	1.00
RAS	activates	gene	1.00
Carcinoma	therapeutic_target	disease	0.95
Als	inhibits	disease	0.95
Cancer	regulates	disease	0.95
Ros	activates	process	0.95
Lung Cancer	therapeutic_target	disease	0.95
Colorectal Cancer	therapeutic_target	disease	0.95
Carcinogenesis	involved_in	process	0.95
cancer	risk_factor_for	disease	0.95
pancreatic ductal adenocarcinoma	risk_factor_for	disease	0.95
cancer	causes	disease	0.95
cancer therapy	therapeutic_target	process	0.93
CRAF	interacts_with	protein	0.92
oncogenic transformation	promotes	process	0.92
Mitofission	associated_with	process	0.90
Mitophagy	associated_with	process	0.90
MAPK	activates	pathway	0.90
Non-Small Cell Lung Cancer	associated_with	disease	0.90
tumors	risk_factor_for	disease	0.90
covalent ligands	therapeutic_target	drug	0.90
cancer cell proliferation	promotes	process	0.90
Autophagy	activates	pathway	0.90
Tumor Microenvironment	therapeutic_target	pathway	0.90
GENES	associated_with	gene	0.90
PIK3CA	associated_with	gene	0.90
EGFR	inhibits	gene	0.90
Carcinoma	associated_with	disease	0.85
Als	associated_with	disease	0.85
Pancreatic Cancer	inhibits	disease	0.85
STAT3	upstream_of	gene	0.85
Ras-Targeting Therapies	targets	drug	0.85
PI3K/AKT/mTOR Pathway	activates	pathway	0.85
AKT	activates	gene	0.80

Incoming (296)

Source	Relation	Type	Str
Merodantoin	activates	drug	0.90
KRAS inhibitors	inhibits	drug	0.90
PTEN	associated_with	gene	0.90
KRAS inhibitors	binds_to	drug	0.88
SOS1	activates	gene	0.85
PRMT1	interacts_with	entity	0.80
GRB2	upstream_of	protein	0.80
ARID1A	associated_with	gene	0.80
ERK	activates	gene	0.70
FGFR3	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
ERK	therapeutic_target	gene	0.70
APOPTOSIS	activates	gene	0.70
RAS	associated_with	protein	0.70
HRAS	associated_with	gene	0.70
PRMT1	inhibits	gene	0.60
VDAC1	expressed_in	gene	0.60
DRP1	activates	gene	0.60
DNM1L	activates	gene	0.60
GABARAP	activates	gene	0.60
WIPI2	activates	gene	0.60
P38	activates	gene	0.60
BRAF	regulates	gene	0.60
AKT	activates	gene	0.60
NFE2L2	activates	gene	0.60
BCL2	therapeutic_target	gene	0.60
PARP1	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
CANCER	regulates	gene	0.60
MTOR	activates	gene	0.60
BAX	activates	gene	0.60
KDM4A	associated_with	gene	0.60
TP53	associated_with	gene	0.60
CD8	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
BCL2L1	activates	gene	0.60
ROS	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
RAS	activates	gene	0.60
OPA1	activates	gene	0.60
HRAS	expressed_in	gene	0.60
TAZ	activates	gene	0.60
ARID1A	regulates	gene	0.60
CDKN2A	inhibits	gene	0.60
KEAP1	activates	gene	0.60
KEAP1	therapeutic_target	gene	0.60
CDKN2A	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KRAS

Understanding Entity Pages

Summary

Wiki Pages (20)

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

RASA3 — Ras GTPase-Activating Protein 3

SHP2 Protein

SUFU — Suppressor of Fused, Hedgehog Pathway Regulator

KDM4A - Lysine Specific Demethylase 4A

ERK2 Protein

RASA1 — RAS p120 GTPase Activating Protein

RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-Raf)

MAPK3 Gene - ERK1

FGFR3 - Fibroblast Growth Factor Receptor 3

rasp

MAP2K1 Gene

WNT2 Gene

MRAS — Muscle RAS Oncogene

ARID1A

Ras/Rap1 Signaling Neurons

MAPK/ERK Signaling Pathway in Neurodegeneration