PTGS2

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTGS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

The PTGS2 gene encodes cyclooxygenase-2 (COX-2), a key enzyme in prostaglandin synthesis that plays a critical role in neuroinflammation and neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS.

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graph TD
    PTGS2["PTGS2"] -->|"Associated With"| Carcinoma["Carcinoma"]
    PTGS2["PTGS2"] -->|"Associated With"| Tumor["Tumor"]
    PTGS2["PTGS2"] -->|"Interacts With"| Ms["Ms"]
    PTGS2["PTGS2"] -->|"Inhibits"| Cancer["Cancer"]
    PTGS2["PTGS2"] -->|"Activates"| Fibrosis["Fibrosis"]
    PTGS2["PTGS2"] -->|"Activates"| Als["Als"]
    PTGS2["PTGS2"] -->|"Therapeutic Target"| Inflammation["Inflammation"]
    PTGS2["PTGS2"] -->|"Therapeutic Target"| Stroke["Stroke"]
    DZSM["DZSM"] -->|"Regulates"| PTGS2["PTGS2"]
    SQSTM1["SQSTM1"] -->|"Associated With"| PTGS2["PTGS2"]
    TNF["TNF"] -->|"Associated With"| PTGS2["PTGS2"]
    ELAVL1["ELAVL1"] -->|"Associated With"| PTGS2["PTGS2"]
    GPX4["GPX4"] -->|"Associated With"| PTGS2["PTGS2"]
    style PTGS2 fill:#8d4900,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style Stroke fill:#b71c1c,color:#e0e0e0
    style DZSM fill:#00838f,color:#e0e0e0
    style SQSTM1 fill:#8d4900,color:#e0e0e0
    style TNF fill:#8d4900,color:#e0e0e0
    style ELAVL1 fill:#8d4900,color:#e0e0e0
    style GPX4 fill:#8d4900,color:#e0e0e0