concept

SPINAL MUSCULAR ATROPHY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPINAL MUSCULAR ATROPHY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

310Connections
0Hypotheses
0Analyses
5Outgoing
50Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameSPINAL MUSCULAR ATROPHY
Key Genes/ProteinsTH, TARDBP
Related PathwaysDNA DAMAGE RESPONSE

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

ALS Failed Approaches Analysis

mechanism · 4973 words

Blood-Brain Barrier Biology and Crossing Strategies

mechanism · 4474 words

TRA2B Protein - Transformer-2 Beta

protein · 4438 words

Splice-Modulating Therapies for Neurodegeneration

mechanism · 4197 words

Pathway Diagram

graph TD
    SPINAL_MUSCULAR_ATROPHY["SPINAL MUSCULAR ATROPHY"]
    SPINAL_MUSCULAR_ATROPHY -->|"regulates"| Fibroblast["Fibroblast"]
    SPINAL_MUSCULAR_ATROPHY -->|"target for"| Cholesterol["Cholesterol"]
    SPINAL_MUSCULAR_ATROPHY -->|"target for"| Neuron["Neuron"]
    SPINAL_MUSCULAR_ATROPHY -->|"expressed in"| Apoptosis["Apoptosis"]
    Gene_Therapy["Gene Therapy"] -->|"treats"| SPINAL_MUSCULAR_ATROPHY
    Nursinersen["Nursinersen"] -->|"treats"| SPINAL_MUSCULAR_ATROPHY
    RNA["RNA"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    ALS["ALS"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    OVERVIEW["OVERVIEW"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    DEMENTIA["DEMENTIA"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    HUNTINGTON["HUNTINGTON"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    PARKINSON["PARKINSON"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY

Outgoing (63)

TargetRelationTypeStr
THassociated_withgene0.50
TARDBPassociated_withgene0.50
DNA DAMAGE RESPONSEassociated_withpathway0.45
CHLOROQUINEassociated_withdrug0.45
RAPAMYCINassociated_withdrug0.45

Incoming (247)

SourceRelationTypeStr
Gene Therapytreatsprocess0.95
Nursinersentreatsdrug0.90
CRISPR-Q systemtherapeutic_targetcompound0.80
MAPTbiomarker_forgene0.80
LDLassociated_withgene0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found