Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MIRNAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MIRNAS is a gene implicated in neurodegeneration research. Key relationships include: regulates, therapeutic target, associated with. Associated with ALS, Aging, Als. Connected to 1199 entities in the SciDEX knowledge graph.
| Gene Symbol | MIRNAS |
| Primary Expression | Ca1, Hippocampus, Prefrontal Cortex, Cortex, Thalamus |
| Pathways | Apoptosis, Immune Response, Oxidative Stress, Differentiation, Microrna |
| GeneCards | MIRNAS |
| Human Protein Atlas | MIRNAS |
| Associated Diseases | ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Atherosclerosis |
| Interactions | USP7, ALOX15, GENES, DNA, STAT3, VDR |
| KG Connections | 1769 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MIRNAS["MIRNAS"] -->|"associated"| Cancer["Cancer"]
MIRNAS["MIRNAS"] -.->|"inhibits"| Als["Als"]
MIRNAS["MIRNAS"] -.->|"inhibits"| Tumor["Tumor"]
MIRNAS["MIRNAS"] -->|"regulates"| Alzheimer["Alzheimer"]
MIRNAS["MIRNAS"] -->|"activates"| Aging["Aging"]
MIRNAS["MIRNAS"] -->|"activates"| Tumor_1["Tumor"]
HNRNPA1["HNRNPA1"] -.->|"inhibits"| MIRNAS["MIRNAS"]
GENES["GENES"] -->|"associated"| MIRNAS["MIRNAS"]
LOX["LOX"] -->|"regulates"| MIRNAS["MIRNAS"]
MICRORNAS["MICRORNAS"] -->|"activates"| MIRNAS["MIRNAS"]
style MIRNAS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| GENES | regulates | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| OVERVIEW | regulates | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Epigenetic | regulates | pathway | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| Cancer | expressed_in | disease | 1.00 |
| MICRORNAS | expressed_in | gene | 1.00 |
| MICRORNAS | therapeutic_target | gene | 1.00 |
| Mapk | regulates | pathway | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| MICRORNAS | regulates | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| MICRORNAS | associated_with | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| Cholesterol | regulates | pathway | 1.00 |
| EXOSOMES | therapeutic_target | gene | 1.00 |
| Als | expressed_in | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Inflammation | expressed_in | disease | 1.00 |
| CANCER | biomarker_for | gene | 1.00 |
| Cancer | biomarker_for | disease | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-test-8d254307 | targets_gene | hypothesis | 0.90 |
| h-test-full-8d254307 | targets_gene | hypothesis | 0.90 |
| MICRORNAS | regulates | gene | 0.70 |
| TP53 | regulates | gene | 0.70 |
| INFLAMMATION | regulates | gene | 0.70 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.70 |
| HNRNPA1 | inhibits | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| LOX | regulates | gene | 0.60 |
| MICRORNAS | activates | gene | 0.60 |
| OVERVIEW | contributes_to | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| TNF | contributes_to | gene | 0.60 |
| IGF2 | therapeutic_target | gene | 0.60 |
| RB1 | therapeutic_target | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| RB1CC1 | therapeutic_target | gene | 0.60 |
| AKT3 | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| PTEN | therapeutic_target | gene | 0.60 |
| BACE1 | therapeutic_target | gene | 0.60 |
| GLUT4 | therapeutic_target | gene | 0.60 |
| NLRP3 | therapeutic_target | gene | 0.60 |
| SIRT1 | therapeutic_target | gene | 0.60 |
| SMAD3 | therapeutic_target | gene | 0.60 |
| OVERVIEW | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| VEGF | activates | gene | 0.60 |
| TRAF6 | biomarker_for | gene | 0.60 |
| P38 | biomarker_for | gene | 0.60 |
| CD4 | biomarker_for | gene | 0.60 |
| EGR2 | biomarker_for | gene | 0.60 |
| TNF | biomarker_for | gene | 0.60 |
| SPI1 | biomarker_for | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| STXBP2 | biomarker_for | gene | 0.60 |
| FLNA | biomarker_for | gene | 0.60 |
| CTSD | biomarker_for | gene | 0.60 |
| MICRORNAS | therapeutic_target | gene | 0.60 |
| OVERVIEW | therapeutic_target | gene | 0.60 |
| SOX9 | therapeutic_target | gene | 0.60 |
| MICRORNAS | associated_with | gene | 0.60 |
| RANK | therapeutic_target | gene | 0.60 |
| ALOX15 | activates | gene | 0.60 |
| HNRNPA1 | activates | gene | 0.60 |
| LOX | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 2 hypotheses Top: 0.490
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||