concept

CYP1A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

336Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CYP1A1 is a concept in neurodegeneration research. Key relationships include: interacts with, associated with, expressed in. Associated with ALS, Cancer, Carcinoma. Connected to 110 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CYP1A1
Key Genes/Proteins	AADC, Actin, AHR, Akt, AKT1, AKT1S1
Related Diseases	Als, ALS
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    CYP1A1["CYP1A1"]
    CYP1A1 -->|"expressed in"| Carcinoma["Carcinoma"]
    CYP1A1 -->|"interacts"| ALS["ALS"]
    CYP1A1 -->|"interacts"| Fibrosis["Fibrosis"]
    CYP1A1 -->|"interacts"| Cancer["Cancer"]
    CYP1A1 -->|"interacts"| P38["P38"]
    CYP1A1 -->|"interacts"| PI3K["PI3K"]
    CYP1A1 -->|"interacts"| MLST8["MLST8"]
    CYP1A1 -->|"interacts"| AUTOPHAGY["AUTOPHAGY"]
    CYP1A1 -->|"interacts"| AKT1["AKT1"]
    CYP1A1 -->|"interacts"| IFN["IFN"]
    ROS["ROS"] -->|"interacts"| CYP1A1
    RICTOR["RICTOR"] -->|"interacts"| CYP1A1
    MTOR["MTOR"] -->|"interacts"| CYP1A1
    MAP1LC3A["MAP1LC3A"] -->|"interacts"| CYP1A1
    LC3["LC3"] -->|"interacts"| CYP1A1
    DNA["DNA"] -->|"interacts"| CYP1A1
    RHEB["RHEB"] -->|"interacts"| CYP1A1
    LYSOSOME["LYSOSOME"] -->|"interacts"| CYP1A1
    MAVS["MAVS"] -->|"interacts"| CYP1A1
    RB1["RB1"] -->|"interacts"| CYP1A1

Outgoing (186)

Target	Relation	Type	Str
Carcinoma	expressed_in	disease	0.80
Cardiovascular	inhibits	disease	0.65
Fibrosis	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Diabetes	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Fibrosis	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Cardiomyopathy	inhibits	disease	0.65
MLKL	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
ROS	regulates	gene	0.60
MAO	regulates	gene	0.60
AADC	regulates	gene	0.60
ROS	inhibits	gene	0.60
SLC2A1	associated_with	gene	0.60
SLC2A1	interacts_with	gene	0.60
NOX4	interacts_with	gene	0.60
RAGE	interacts_with	gene	0.60
Cardiomyocyte	inhibits	cell_type	0.60
Caspase	inhibits	protein	0.60
Ngf	inhibits	protein	0.60
NLR	interacts_with	gene	0.60
Caspase	interacts_with	protein	0.60
Rb	interacts_with	protein	0.60
Stat3	interacts_with	protein	0.60
Actin	interacts_with	protein	0.60
Akt	interacts_with	protein	0.60
oxidative stress response	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
MMP2	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60

Incoming (150)

Source	Relation	Type	Str
Aryl Hydrocarbon Receptor	associated_with	protein	0.70
SQSTM1	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MAO-B	regulates	gene	0.60
rapamycin	targets	drug	0.60
RB1CC1	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.703

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

closed · Rounds: 4 · Score: 0.84 · 2026-04-16

Related Research

Hypotheses and analyses mentioning CYP1A1 in their description or question text

No additional research found