concept

RA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

158Connections

30Hypotheses

5Analyses

0Outgoing

50Incoming

11Experiments

6Debates

Summary

RA is a concept in neurodegeneration research. Key relationships include: implicated in, associated with. Connected to 158 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	RA
Key Genes/Proteins	A2M, ABCA1, ABCB1, ABCG1, ACTB, AGER
Linked Hypotheses	20 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RA["RA"]
    MAP1B["MAP1B"] -->|"implicated in"| RA
    MAP2["MAP2"] -->|"implicated in"| RA
    MAP6["MAP6"] -->|"implicated in"| RA
    GLUT4["GLUT4"] -->|"implicated in"| RA
    PPAR["PPAR"] -->|"implicated in"| RA
    RAB7A["RAB7A"] -->|"implicated in"| RA
    LRP2["LRP2"] -->|"implicated in"| RA
    ACTB["ACTB"] -->|"implicated in"| RA
    CTSD["CTSD"] -->|"implicated in"| RA
    ATG["ATG"] -->|"implicated in"| RA

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (158)

Source	Relation	Type	Str
RBP	associated_with	protein	0.56
MAP1B	implicated_in	gene	0.50
MAP2	implicated_in	gene	0.50
MAP6	implicated_in	gene	0.50
GLUT4	implicated_in	gene	0.50
PPAR	implicated_in	gene	0.50
SLC16A2	implicated_in	gene	0.50
SLC16A1	implicated_in	gene	0.50
GSS	implicated_in	gene	0.50
CYP2E1	implicated_in	gene	0.50
IDH2	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50
RASA1	implicated_in	gene	0.50
AQP4	implicated_in	gene	0.50
MOG	implicated_in	gene	0.50
CD40	implicated_in	gene	0.50
TCR	implicated_in	gene	0.50
SPP1	implicated_in	gene	0.50
GBM	implicated_in	gene	0.50
C1QA	implicated_in	gene	0.50
C1QC	implicated_in	gene	0.50
C1Q	implicated_in	gene	0.50
SPI1	implicated_in	gene	0.50
UNC5B	implicated_in	gene	0.50
NTN1	implicated_in	gene	0.50
GPNMB	implicated_in	gene	0.50
NPTX2	implicated_in	gene	0.50
VGF	implicated_in	gene	0.50
PTN	implicated_in	gene	0.50
NTN3	implicated_in	gene	0.50
TARDBP	implicated_in	gene	0.50
SNRNP70	implicated_in	gene	0.50
AGER	implicated_in	gene	0.50
HSPA1A	implicated_in	gene	0.50
HSPA1B	implicated_in	gene	0.50
ERK1	implicated_in	gene	0.50
JNK	implicated_in	gene	0.50
STING	implicated_in	gene	0.50
IRF3	implicated_in	gene	0.50
IFN	implicated_in	gene	0.50
DOT1L	implicated_in	gene	0.50
PLCG2	implicated_in	gene	0.50
ABCB1	implicated_in	gene	0.50
PRMT5	implicated_in	gene	0.50
PRMT1	implicated_in	gene	0.50
PHGDH	implicated_in	gene	0.50
FASN	implicated_in	gene	0.50
EGR1	implicated_in	gene	0.50
KRAS	implicated_in	gene	0.50
G3BP1	implicated_in	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.968	alzheimers	Circuit-level neural dynamics in neurode
GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Cl	0.964	neuroscience	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.955	alzheimers	Circuit-level neural dynamics in neurode
Cortico-Striatal Synchrony Restoration via NMDA Modulation	0.950	neuroscience	Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy	0.946	alzheimers	Circuit-level neural dynamics in neurode

Plasma NfL Elevation Secondary to BBB-Associated Transport D	0.940	-	What blood-brain barrier permeability ch
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Rece	0.937	neuroscience	Circuit-level neural dynamics in neurode
Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming	0.924	neurodegeneration	What are the mechanisms by which gut mic
Closed-loop transcranial focused ultrasound to restore hippo	0.912	alzheimers	Circuit-level neural dynamics in neurode
eIF2α Phosphorylation Imbalance Creates Integrated Stress Re	0.896	als	-
APOE-Dependent Autophagy Restoration	0.895	neurodegeneration	Survival Analysis of AD Patient Cohorts:
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener	0.892	neurodegeneration	Gene expression changes in aging mouse b
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.887	neurodegeneration	How do different microglial subtypes (DA
Beta-frequency entrainment therapy targeting PV interneuron-	0.884	alzheimers	Circuit-level neural dynamics in neurode
Circadian Glymphatic Entrainment via Targeted Orexin Recepto	0.882	neurodegeneration	Perivascular spaces and glymphatic clear
TBK1 Loss Locks Microglia in an Aged/Senescent Transcription	0.878	als	What are the mechanisms by which microgl
RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA P	0.868	als	-
Closed-loop transcranial focused ultrasound to restore hippo	0.865	alzheimers	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.865	alzheimers	Circuit-level neural dynamics in neurode
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.865	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
Glymphatic-Mediated Tau Clearance Dysfunction	0.865	neuroscience	Proteomics Differential Expression in AD
Alpha-theta entrainment therapy to enhance default mode netw	0.000	alzheimers	Circuit-level neural dynamics in neurode
TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagatio	0.000	als	What are the mechanisms by which microgl
LDLR-Mediated Neurosteroid Precursor Delivery Strategy	0.000	neuropharmacology	What is the actual quantitative contribu
LAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy	0.000	proteomics	Quantitative proteomics of the aging syn
TBK1 Loss Triggers eIF2α-Mediated Translational Repression T	0.000	als	What are the mechanisms by which microgl
Closed-loop transcranial focused ultrasound to restore hippo	0.000	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with gamma entra	0.000	alzheimers	Circuit-level neural dynamics in neurode
GLUT1-Mediated Carrier-Conjugate Delivery Strategy	0.000	neuropharmacology	What is the actual quantitative contribu
LDLR-Primed LRP1 Transcytosis with pH-Responsive Escape Stra	0.000	neuropharmacology	What is the actual quantitative contribu

Mentioning Analyses (5)

Scientific analyses that reference this entity

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

neuropharmacology | 2026-04-25 | 4 hypotheses Top: 0.659

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

neurodegeneration | 2026-04-24 | 5 hypotheses Top: 0.790

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

neurodegeneration | 2026-04-23 | 7 hypotheses Top: 0.780

What amyloid threshold level is required for optimal clinical benefit in early A

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.577

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis	clinical	Alzheimer's Disease	0.400	0.50	human	completed	$6,550,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787]	Tomioka R, Kobayashi K, Song WJ	Neuroscience	2026	0
Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202]	Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh	Theranostics	2026	0
A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466]	Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H	Korean J Ophthalmol	2026	0
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871]	Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo	Science translational medicine	2026	0
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733]	Liu K, Zhang XY, Wang YT, Wang R, Jin RH	Molecular neurobiology	2026	0
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138]	Singer Y, Yitzhaky A, Hertzberg L	Alpha psychiatry	2026	0
Paracrine inhibition via G protein inwardly rectifying potassium channels regula [PMID:41824458]	Panzer JK, Lang AL, Levi NJ, Garcia PA,	Cell reports	2026	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
GADD45G operates as a pathological sensor orchestrating reactive gliosis and neu [PMID:40409253]	Shen T, Tai W, Jiang D, Ma S, Zhong X, Z	Neuron	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073]	Castanho I, Naderi Yeganeh P, Boix CA, M	Molecular neurodegeneration	2025	0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resista [PMID:39868232]	Castanho I, Yeganeh PN, Boix CA, Morgan	bioRxiv : the preprint server	2025	0
From stress to Alzheimer's: A circuit-based framework for prefrontal cognitive d [PMID:41115499]	Yi JH	Neuroscience letters	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Hippocampal Interneurons Shape Spatial Coding Alterations in Neurological Disord [PMID:40392508]	Ikebara JM, Jorge RS, Marinho LSR, Higa	Molecular neurobiology	2025	0
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024	0
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024	0
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024	0

Debates (6)

Multi-agent debates referencing this entity

The debate highlighted that G2019S shows elevated baseline RAB10 phosphorylation

closed · Rounds: 4 · Score: 0.80 · 2026-04-26

Hypothesis debate: Multi-Biomarker Composite Index Surpassing Amyloid PET for Tr

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

closed · Rounds: 4 · Score: 0.74 · 2026-04-24

While the study demonstrates dose-response relationships between amyloid levels

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning RA in their description or question text

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables L

Score: 0.940 · unknown disease · 2026-04-26

Neurofilament light chain (NfL) is released from damaged neurofilaments into the extracellular space, flowing into CSF a

Microglial-Mediated Tau Clearance Dysfunction via TREM2 Receptor Impairment

Score: 0.937 · neuroscience · 2026-04-12

**Molecular Mechanism and Rationale** The molecular foundation of this hypothesis centers on the disruption of the TREM

Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration

Score: 0.924 · neurodegeneration · 2026-04-05

## Mechanistic Overview Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration proposes that

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.912 · alzheimers · 2026-04-12

## Mechanistic Overview The molecular foundation of this therapeutic approach centers on the distinctive electrophysiol

APOE-Dependent Autophagy Restoration

Score: 0.895 · neurodegeneration · 2026-04-02

## Mechanistic Overview APOE-Dependent Autophagy Restoration proposes targeting the mechanistic link between apolipopro

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

Score: 0.892 · neurodegeneration · 2026-04-07

## Mechanistic Overview TREM2 (Triggering Receptor Expressed on Myeloid cells 2) is a type I transmembrane glycoprotein

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

Score: 0.887 · neurodegeneration · 2026-04-16

## Mechanistic Overview The therapeutic hypothesis centers on the critical role of interferon-gamma (IFNγ), encoded by

Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling f

Score: 0.884 · alzheimers · 2026-04-05

## Mechanistic Overview Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling proposes that mo

Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation

Score: 0.882 · neurodegeneration · 2026-04-02

## Mechanistic Overview This therapeutic hypothesis proposes leveraging orexin (hypocretin) receptor modulation to enha

TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling AL

Score: 0.878 · als · 2026-04-26

The hypothesis proposes that loss-of-function mutations in TBK1 contribute to ALS pathogenesis by trapping microglia in

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.865 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Score: 0.865 · alzheimers · 2026-04-07

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activatio

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Score: 0.865 · molecular-neurobiology · 2026-04-17

## Mechanistic Overview Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Spe

RA

Understanding Entity Pages

Summary

Wiki Pages (20)

TRA2B Protein - Transformer-2 Beta

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

RAB9A

RRAS3 — Related RAS Virus (R-Ras) Family Member 3

IL1RAP — Interleukin-1 receptor accessory protein

RAD21 — Cohesin Complex Component in Neurodegeneration

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

RAN Translation in Neurodegeneration

RRAGB — Ras-Related GTP Binding B

RAB4B Gene

RAB35 — Ras-Associated Protein 35

RAB43 Gene

PILRA Gene

TRAIL Gene (TNFSF10)

RAB39B Endosomal-Lysosomal Dysfunction PD Causal Chain

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

RAB2A Gene

RABEP1

RAC1 Gene

Pathway Diagram

Outgoing (0)

Incoming (158)

Targeting Hypotheses (30)

Mentioning Analyses (5)

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

What amyloid threshold level is required for optimal clinical benefit in early A

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

Experiments (11)

Related Papers (20)

Debates (6)

The debate highlighted that G2019S shows elevated baseline RAB10 phosphorylation

Hypothesis debate: Multi-Biomarker Composite Index Surpassing Amyloid PET for Tr

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

While the study demonstrates dose-response relationships between amyloid levels

The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP

Related Research

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables L

Microglial-Mediated Tau Clearance Dysfunction via TREM2 Receptor Impairment

Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

APOE-Dependent Autophagy Restoration

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling f

Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation

TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling AL

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV