Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adra2a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADRA2A |
| Target Class | Gpcr |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Small molecule agonists and antagonists modulating noradrenergic signaling |
| Druggability | Medium (0.59) |
| Clinical Stage | Approved |
| GeneCards | ADRA2A |
| Human Protein Atlas | ADRA2A |
| Drug | Use |
| Clonidine | Hypertension, ADHD |
| Guanfacine | Hypertension, ADHD |
| Dexmedetomidine | Sedation |
| Brimonidine | Glaucoma |
| Yohimbine | Reversal of α2 blockade |
| Atipamezole | Veterinary reversal |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | Dexmedetomidine, Clonidine |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Noradrenergic-Tau Propagation Blockade |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ADRA2A["ADRA2A"]
ADRA2A -->|"target for"| Dementia["Dementia"]
ADRA2A -->|"target for"| Epigenetic["Epigenetic"]
ADRA2A -->|"target for"| GENES["GENES"]
ADRA2A -->|"implicated in"| neurodegeneration["neurodegeneration"]
h_4113b0e8["h-4113b0e8"] -->|"target for"| ADRA2A
PER["PER"] -->|"interacts"| ADRA2A
GENES -->|"interacts"| ADRA2A| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | implicated_in | disease | 0.50 |
| benchmark_ot_ad_answer_key:ADRA2A | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ADRA2A | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||