gene

NR3C1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR3C1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

660Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

NR3C1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, interacts with, regulates. Associated with ALS, Als, Alzheimer. Connected to 195 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NR3C1
Aliases	Glucocorticoid receptor, GR, GCR
Chromosome	5q31.3
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	Selective glucocorticoid receptor modulators (SRMs) or antagonists
Mechanism of Action	Selective glucocorticoid receptor modulators (SRMs) or antagonists
Druggability	Medium (0.53)
Clinical Stage	Approved
Molecular Weight	86 kDa
Amino Acids	777 aa
Pathways	HPA axis, NF-kB suppression, MAPK signaling, Circadian rhythm
UniProt ID	F1D8N4
GeneCards	NR3C1
Human Protein Atlas	NR3C1
Associated Diseases	ALS, Addiction, Alzheimer, Alzheimer'S Disease
Known Drugs/Compounds	Dazucorilant, dexamethasone, Corticosterone, Melatonin
Interactions	CRH, TNFA, JUN, BDNF, IL18BP, CALCA
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	660 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: NR3C1 — PDB 1M2Z Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NR3C1["NR3C1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    NR3C1["NR3C1"] -->|"interacts"| CRH["CRH"]
    NR3C1["NR3C1"] -->|"interacts"| TNFA["TNFA"]
    NR3C1["NR3C1"] -->|"co discussed"| DRD2["DRD2"]
    NR3C1["NR3C1"] -->|"co discussed"| CHR2["CHR2"]
    NR3C1["NR3C1"] -->|"co discussed"| CLOCK["CLOCK"]
    CRH_1["CRH"] -->|"interacts"| NR3C1["NR3C1"]
    TNFA_2["TNFA"] -->|"interacts"| NR3C1["NR3C1"]
    FOXP3["FOXP3"] -->|"co discussed"| NR3C1["NR3C1"]
    TNFA_3["TNFA"] -->|"co discussed"| NR3C1["NR3C1"]
    style NR3C1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (429)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
HPA axis	involved_in	pathway	0.95
Hypothalamic-Pituitary-Adrenal Axis	regulates	pathway	0.85
Alzheimer's Disease	associated_with	disease	0.85
emotional aspects of tinnitus	mediates	phenotype	0.85
Cognitive Function	involved_in	phenotype	0.80
stress response	mediates	process	0.80
HPA_axis	regulates	pathway	0.80
Hypothalamic-Pituitary-Adrenal Axis	involved_in	pathway	0.75
Alzheimer'S Disease	associated_with	disease	0.75
Hypersexual Disorder	associated_with	disease	0.70
Hypersexual Disorder	biomarker_for	disease	0.70
Melatonin	involved_in	drug	0.70
NF-kB signaling	participates_in	pathway	0.70
cortex	expressed_in	brain_region	0.70
epigenetic regulation	participates_in	pathway	0.70
Alzheimer's disease	biomarker_for	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Myasthenia Gravis	interacts_with	disease	0.65
Addiction	methylates	disease	0.65
Ptsd	inhibits	disease	0.65
Ptsd	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Als	activates	disease	0.65
Ms	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Autoimmune	interacts_with	disease	0.65
ALS	activates	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Anxiety	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
ALS	regulates	disease	0.65
Ms	interacts_with	disease	0.65

Incoming (231)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
Haloperidol	upregulates	drug	0.90
Dazucorilant	targets	drug	0.90
h-1e564178	targets_gene	hypothesis	0.90
miR-137-3p	regulates	biomarker	0.85
Corticosterone	binds	compound	0.85
h-1e564178	targets	hypothesis	0.80
CRH	co_mentioned_with	gene	0.80
FKBP5	co_mentioned_with	gene	0.80
Melatonin	targets	drug	0.80
dexamethasone	regulates	compound	0.70
DNA	methylates	gene	0.70
CRH	interacts_with	gene	0.61
TNFA	interacts_with	gene	0.61
BDNF	co_mentioned_with	gene	0.60
MMP2	therapeutic_target	entity	0.60
CEBPA	protects_against	entity	0.60
CRH	associated_with	gene	0.60
FKBP5	interacts_with	gene	0.60
CRHR1	interacts_with	gene	0.60
CRH	expressed_in	gene	0.60
AVP	expressed_in	gene	0.60
POMC	expressed_in	gene	0.60
CRHR1	expressed_in	gene	0.60
IL18	inhibits	gene	0.60
RAMP1	inhibits	gene	0.60
FKBP5	inhibits	gene	0.60
CRH	inhibits	gene	0.60
CRHR1	inhibits	gene	0.60
TNF	associated_with	gene	0.60
JUN	associated_with	gene	0.60
TNF	expressed_in	gene	0.60
ESR2	expressed_in	gene	0.60
JUN	activates	gene	0.60
ESR1	expressed_in	gene	0.60
CALCA	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
BNIP3	activates	gene	0.60
LRP1	interacts_with	gene	0.60
SLC6A4	expressed_in	gene	0.60
DICER1	expressed_in	gene	0.60
CASP3	interacts_with	gene	0.60
FKBP5	activates	gene	0.60
PVALB	interacts_with	gene	0.60
EGR1	protects_against	gene	0.60
ATF3	protects_against	gene	0.60
BANG	regulates	gene	0.60
PPARG	protects_against	gene	0.60
APP	activates	gene	0.60
TNF	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NR3C1

Understanding Entity Pages

Summary

Wiki Pages (20)

Glucocorticoid Signaling Pathway in Neurodegeneration

cortisol-tau-pathway

Biomarkers of Alzheimer Disease

Biomarker-Therapeutic Development Nexus

Hypothalamic-Pituitary-Adrenal Axis

Biomarkers in Neurodegeneration

Actinogen Medical

Biomarkers for Parkinson's Disease

Biomarkers for Corticobasal Degeneration

Biomarkers for Progressive Supranuclear Palsy

Biomarker Discovery Framework for Neurodegenerative Diseases

HPA Axis Neurons in Neurodegeneration

TNF Gene

Biomarkers in Parkinsonian Syndromes (NCT06501469)

Bed Nucleus of Stria Terminalis in Stress

Biomarker-Based Classification of Corticobasal Syndrome

Biomarker Validation Study for AD Combination Therapy