concept

LCN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LCN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

218Connections

0Hypotheses

0Analyses

50Outgoing

49Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LCN2
Key Genes/Proteins	SATB2, ATG4B, YY1
Related Diseases	Neuronal Dysfunction, Dry Age-Related Macular Degeneration, Cerebral Ischemia/Reperfusion Injury, Lung Tumor Growth
Related Pathways	NLRP3 Inflammasome

Wiki Pages (8)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LCN2["LCN2"]
    style LCN2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    LCN2 -.->|"inhibits"| Autophagy["Autophagy"]
    LCN2 -->|"binds"| ATG4B([ATG4B])
    LCN2 -.->|"inhibits"| Macroautophagy["Macroautophagy"]
    LCN2 -->|"promotes"| astrocyte_senescence["astrocyte senescence"]
    LCN2 -->|"regulates"| LC3_II([LC3-II])
    LCN2 -->|"activates"| Inflammasome_Ferroptosis["Inflammasome-Ferroptosis"]
    LCN2 -->|"mediates"| Ferroptosis["Ferroptosis"]
    LCN2 -->|"contributes to"| Dry_AMD["Dry AMD"]
    LCN2 -.->|"biomarker for"| Stevens_Johnson_Syndrome["Stevens-Johnson Syndrome"]
    LCN2 -.->|"inhibits"| autophagy["autophagy"]
    YY1([YY1]) -->|"regulates"| LCN2
    ATG4B -->|"interacts"| LCN2
    PYROPTOSIS([PYROPTOSIS]) -->|"activates"| LCN2
    STROKE([STROKE]) -->|"activates"| LCN2
    APOPTOSIS([APOPTOSIS]) -->|"activates"| LCN2
    CSF1([CSF1]) -->|"activates"| LCN2
    RNA([RNA]) -->|"activates"| LCN2
    FERROPTOSIS([FERROPTOSIS]) -->|"activates"| LCN2
    ASTROCYTE([ASTROCYTE]) -->|"activates"| LCN2
    ADORA1([ADORA1]) -->|"activates"| LCN2

Outgoing (169)

Target	Relation	Type	Str
Astrocyte Pyroptosis	mediates	process	0.95
Tunnel Nanotube-Mediated Mitochondrial Transfer	suppresses	process	0.95
Neuronal Dysfunction	causes	phenotype	0.95
Autophagy	inhibits	process	0.90
ATG4B	binds	protein	0.90
Dry Age-Related Macular Degeneration	associated_with	disease	0.90
NLRP3 Inflammasome	activates	pathway	0.90
Cerebral Ischemia/Reperfusion Injury	contributes_to	disease	0.90
Astrocytes	expressed_in	cell_type	0.90
Astrocyte Activation	promotes	process	0.90
Ferroptosis	regulates	process	0.90
Lung Tumor Growth	promotes	phenotype	0.90
Macroautophagy	inhibits	process	0.88
astrocyte senescence	promotes	process	0.88
Lung Metastasis	promotes	phenotype	0.86
LC3-II	regulates	protein	0.85
Inflammasome-Ferroptosis	activates	pathway	0.85
Ferroptosis	mediates	process	0.85
24p3R	binds	receptor	0.85
Memory Impairment	promotes	phenotype	0.85
ferroptosis	promotes	process	0.85
Non-Small Cell Lung Cancer	drives	disease	0.85
iron homeostasis	regulates	process	0.85
INFLAMMATION	mediates	process	0.85
Tumor Growth	promotes	phenotype	0.84
Dry AMD	contributes_to	disease	0.80
iron metabolism	regulates	pathway	0.80
inflammation	promotes	process	0.75
autophagy	inhibits	pathway	0.72
ATG4B	interacts_with	protein	0.72
HMGB1	activates	protein	0.70
NRF2	inhibits	protein	0.70
blood-brain barrier	inhibits	cell_type	0.70
Macular Degeneration	activates	disease	0.65
Pyroptosis	activates	disease	0.65
Necroptosis	activates	disease	0.65
Als	activates	disease	0.65
Stroke	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	biomarker_for	disease	0.65
Retinopathy	contributes_to	disease	0.65
Diabetes	contributes_to	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Senescence	activates	disease	0.65
inflammasome	activates	pathway	0.64
ferroptosis	activates	pathway	0.64
iron_homeostasis	regulates	pathway	0.64

Incoming (49)

Source	Relation	Type	Str
SATB2	associated_with	gene	0.95
YY1	regulates	protein	0.90
ADORA1	promotes	receptor	0.90
Bezafibrate	downregulates	drug	0.90
H3K9 Lactylation	upregulates	process	0.90
Seizures	upregulates	phenotype	0.90
SATB2	binds	protein	0.85
Lactate	upregulates	compound	0.80
ATG4B	interacts_with	gene	0.60
PYROPTOSIS	activates	gene	0.60
STROKE	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CSF1	activates	gene	0.60
RNA	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
ADORA1	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU	activates	gene	0.60
MAPT	activates	gene	0.60
MEF2C	activates	gene	0.60
SIRT3	activates	gene	0.60
ATP	activates	gene	0.60
EGFR	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MTOR	activates	gene	0.60
ARG1	activates	gene	0.60
IL-10	activates	gene	0.60
CHI3L1	activates	gene	0.60
MMP9	activates	gene	0.60
P53	inhibits	gene	0.60
EXOSOMES	activates	gene	0.60
MTDNA	activates	gene	0.60
S100A8	expressed_in	gene	0.60
COX2	activates	gene	0.60
S100A9	expressed_in	gene	0.60
TFAM	activates	gene	0.60
OSMR	expressed_in	gene	0.60
DNA	activates	gene	0.60
ATG4B	regulates	gene	0.60
LC3	regulates	gene	0.60
HDAC3	activates	gene	0.60
GFAP	inhibits	gene	0.60
GFAP	activates	gene	0.60
GSDMD	activates	gene	0.60
HMGB1	activates	gene	0.60
GSDMD	associated_with	gene	0.60
GJA1	biomarker_for	gene	0.60
KRAS	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LCN2

Understanding Entity Pages

Wiki Pages (8)

Astrocytes

cGAS-STING Signaling in Parkinson's Disease

ATG4B — Autophagy Related 4B Cysteine Peptidase

SATB2 - Special AT-Rich Sequence Binding Protein 2

Neurotoxic Astrocytes

Spinal Cord Astrocytes in Neurodegeneration