concept

LOX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

671Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

LOX is a concept in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with AD, ALS, AMI. Connected to 270 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	LOX
Related Diseases	Glioma, Cancer Prognosis, Poor Survival, Overall Survival, overall survival
Related Pathways	oxidative stress response
Linked Hypotheses	2 hypotheses

🔮 Predicted Structure: LOX — AlphaFold B7ZAJ4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LOX["LOX"]
    LOX -->|"expressed in"| macrophages["macrophages"]
    LOX -->|"regulates"| OLFML3["OLFML3"]
    LOX -->|"activates"| macrophage["macrophage"]
    LOX -->|"activates"| ITGB1["ITGB1"]
    LOX -.biomarker for.-> glioblastoma_multiforme["glioblastoma multiforme"]
    LOX -->|"activates"| _1_integrin["beta1 integrin"]
    LOX -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    LOX -->|"interacts"| Als["Als"]
    h_82922df8["h-82922df8"] -->|"targets"| LOX
    YAP1["YAP1"] -->|"activates"| LOX
    LOXL1_4["LOXL1-4"] -->|"interacts"| LOX
    ACTB["ACTB"] -->|"interacts"| LOX
    P2RY12["P2RY12"] -->|"inhibits"| LOX
    APOA1["APOA1"] -->|"interacts"| LOX
    ULK1["ULK1"] -->|"interacts"| LOX
    ATG5["ATG5"] -->|"interacts"| LOX
    EIF4EBP1["EIF4EBP1"] -->|"interacts"| LOX
    LC3["LC3"] -->|"interacts"| LOX

Outgoing (466)

Target	Relation	Type	Str
Cancer Progression	involved_in	process	0.95
Cancer Progression	promotes	process	0.95
Macrophages	expressed_in	cell_type	0.95
Glioma	associated_with	disease	0.92
Cancer Prognosis	biomarker_for	phenotype	0.90
Tumor Progression	correlates_with	process	0.90
Poor Survival	risk_factor_for	phenotype	0.90
Macrophage Infiltration	regulates	process	0.90
Overall Survival	biomarker_for	phenotype	0.90
tumor progression	promotes	process	0.90
overall survival	risk_factor_for	phenotype	0.90
oxidative stress response	participates_in	pathway	0.90
neuronal cell	expressed_in	cell_type	0.90
Therapeutic Response	associated_with	phenotype	0.85
Cancer	activates	disease	0.85
Tumor	activates	disease	0.85
Glioma	biomarker_for	disease	0.85
Alzheimer's Disease	implicated_in	disease	0.85
Alzheimer's Disease	therapeutic_target	disease	0.80
lysyl_oxidase	encodes	protein	0.80
drug sensitivity	associated_with	phenotype	0.75
Alzheimer	regulates	disease	0.75
Alzheimer	activates	disease	0.75
Diabetes	activates	disease	0.75
Cardiovascular	activates	disease	0.75
Autoimmune	activates	disease	0.75
Inflammation	activates	disease	0.75
AKT	inhibits	gene	0.70
INFLAMMATION	activates	gene	0.70
hippocampus	expressed_in	brain_region	0.70
OLFML3	regulates	protein	0.70
macrophage	activates	cell_type	0.70
glioblastoma multiforme	biomarker_for	disease	0.70
macrophage	expressed_in	cell_type	0.70
β1 integrin	activates	protein	0.70
macrophage	regulates	cell_type	0.70
macrophages	expressed_in	cell_type	0.70
ITGB1	activates	protein	0.70
Cerebral Amyloid Angiopathy	expressed_in	disease	0.65
Encephalitis	activates	disease	0.65
Cerebral Amyloid Angiopathy	therapeutic_target	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Als	contributes_to	disease	0.65
Cardiovascular	contributes_to	disease	0.65
Inflammation	associated_with	disease	0.65
Aging	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65

Incoming (205)

Source	Relation	Type	Str
h-82922df8	targets_gene	hypothesis	0.90
h-82922df8	targets	hypothesis	0.80
LOXL3	interacts_with	gene	0.80
Aβ42 oligomers	modulates	compound	0.80
APP	associated_with	gene	0.75
PI3K	inhibits	gene	0.70
ALZHEIMER	regulates	gene	0.70
ALZHEIMER	activates	gene	0.70
CYTOKINES	activates	gene	0.70
YAP1	activates	protein	0.70
MAO-A	interacts_with	protein	0.70
LOXL1-4	interacts_with	gene	0.64
ABCA1	activates	entity	0.60
ABCG1	activates	entity	0.60
ACTB	activates	entity	0.60
APOA1	activates	entity	0.60
ATG5	activates	entity	0.60
EIF4EBP1	activates	entity	0.60
LC3	activates	entity	0.60
ALS	activates	entity	0.60
AMPK	activates	entity	0.60
CANCER	regulates	entity	0.60
CANCER	expressed_in	entity	0.60
CANCER	associated_with	entity	0.60
CANCER	treats	entity	0.60
DEPRESSION	protects_against	entity	0.60
ACTB	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
APOA1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
EIF4EBP1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
ABCG1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
APOE	inhibits	gene	0.60
ALOX15	associated_with	gene	0.60
ALOX15	regulates	gene	0.60
SPP1	associated_with	gene	0.60
BIN1	regulates	gene	0.60
P62	interacts_with	gene	0.60
AKT	inhibits	gene	0.60
VDR	regulates	gene	0.60
LOX/LOXL1-4	regulates	gene	0.60
LOXL1-4	stabilizes	gene	0.60
LOX/LOXL1-4	stabilizes	gene	0.60
JUN	expressed_in	gene	0.60
TNF	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th	0.455	neurodegeneration	Neuroinflammation resolution mechanisms

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134]	Yang J, Borchert A, Kuhn H	J Biol Chem	2026	1
Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924]	Cai W, Liu L, Shi X, Liu Y, Wang J, Fang	Circulation	2023	1
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829]	Tong J, Lan XT, Zhang Z, Liu Y, Sun DY,	Acta Pharmacol Sin	2023	1
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859]	Zhang H, Deng T, Liu R, Ning T, Yang H,	Mol Cancer	2020	1
Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102]	Zhao Y, Bhattacharjee S, Jones BM, Hill	Mol Neurobiol	2014	1
ALOX15 exerts tumor-suppressive role in head and neck squamous cell carcinoma vi [PMID:41820595]	Liu A, Zhang X, Li R, Zhang Y, Yang Z, Z	Functional & integrative genom	2026	0
Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 C [PMID:41589658]	Hou G, Luan J, Xu X, Qin J, Ma S et al.	Adv Sci (Weinh)	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Sanhua essential oil exerts antidepressant effects in breast cancer-related depr [PMID:41722126]	Li X, Xu Z, Ju P, Dong M, Wang Y et al.	Phytomedicine	2026	0
Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inh [PMID:41947243]	Zhang Q, Yu J, Zheng Y, Jiang J, Zheng L	Stem Cell Res Ther	2026	0
Immune dysregulation in fibromyalgia: Targeting the NLRP3 inflammasome-ferroptos [PMID:41962813]	Fawzy MN, Badawi GA, El-Sayed RM	Clin Immunol	2026	0
Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Develop [PMID:41750540]	Man GCW, Borchert A, Zhang T, Hung SW, K	Antioxidants (Basel, Switzerla	2026	0
ALOX15-Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq-P [PMID:41847922]	Hilman A, Ishii Y, Wijatniko BD, Rini DM	FASEB journal : official publi	2026	0
Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunct [PMID:41746293]	Zhou L, Bai Q, Shi R, Zeng X, Deng J, Lu	FASEB journal : official publi	2026	0
FGF21 promotes the resolution of inflammation through the ALOX15/SPM pathway in [PMID:41913238]	Shen C, Cao Y, Wei J, Tian X, Zhang C, W	Respiratory research	2026	0
Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic do [PMID:39882747]	Deng S, Cao H, Li T, Wang X, Meng J, Zen	Gut microbes	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early [PMID:39362839]	Yang X, Chen H, Shen W, Chen Y, Lin Z, Z	Nature communications	2024	0
Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer ba [PMID:37469520]	Shen L, Huang H, Li J, Chen W, Yao Y, Hu	Frontiers in immunology	2023	0
A survey of human brain transcriptome diversity at the single cell level. [PMID:26060301]	["Darmanis S", "Sloan S", "Zhang Y", "En	Proceedings of the National Ac	2015	0

LOX

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Astrocyte Reactivity Mechanism

CNTN5 — Contactin 5

omega-3-fatty-acids-neurodegeneration

Sulforaphane and Nrf2 Activation for Neuroprotection

Neurogenesis

Ferroptosis in Neurodegeneration

CD200R1 Gene

Neuronal Migration

Ventral Pallidum GABAergic Neurons

DNA Damage Response in Corticobasal Syndrome

Astrocyte Senescence Pathway in Neurodegeneration

ASC (PYCARD)

Ferroptosis in Alzheimer's Disease

MEKK3 Protein

RAN Gene

Ferroptosis Pathway in Neurodegeneration

NF-κB Pathway Inhibition for Neurodegeneration