protein

PCNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PCNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

36Outgoing

38Incoming

Summary

Page for PCNA Protein (Proliferating Cell Nuclear Antigen)

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🔬 Protein Info

Gene Symbol	PCNA
Aliases	Proliferating Cell Nuclear Antigen
Function	Beyond its canonical roles in DNA replication, PCNA has been implicated in various neurodegenerative diseases, particularly those involving DNA repair dysfunction and replicative stress.
Molecular Weight	28.8 kDa
GeneCards	PCNA
Human Protein Atlas	PCNA
Associated Diseases	ALS
Known Drugs/Compounds	rapamycin
Interactions	PI3K, PIK3CA, PSMA1, PSMB5, RPS6KB1, SMAD
KG Connections	74 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

GADD45G as Pathological Sensor: Orchestrating Reactive Gliosis in Neurodegeneration

mechanism · 2512 words

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Pathway Diagram

graph TD
    PCNA("PCNA")
    DNA_repair["DNA repair"]
    PCNA -->|"participates_in"| DNA_repair
    DNA["DNA"]
    PCNA -->|"binds"| DNA
    APE2["APE2"]
    APE2 -->|"binds"| PCNA
    Cinobufagin["Cinobufagin"]
    Cinobufagin -->|"downregulates"| PCNA
    p15["p15"]
    PCNA -->|"binds"| p15
    EHMT2["EHMT2"]
    PCNA -->|"interacts_with"| EHMT2
    CASPASE3("CASPASE3")
    PCNA -->|"interacts_with"| CASPASE3
    BCL_2("BCL-2")
    PCNA -->|"interacts_with"| BCL_2
    Lymphoma{"Lymphoma"}
    PCNA -->|"interacts_with"| Lymphoma
    FOXO1["FOXO1"]
    FOXO1 -->|"interacts_with"| PCNA
    BCL2["BCL2"]
    BCL2 -->|"interacts_with"| PCNA
    FOXO1 -->|"associated_with"| PCNA

Outgoing (36)

Target	Relation	Type	Str
DNA repair	participates_in	biological_process	0.90
DNA	binds	entity	0.80
uterine proliferation	upregulates	process	0.75
p15	binds	entity	0.70
PI3K	activates	gene	0.60
PIK3CA	activates	gene	0.60
PSMA1	activates	gene	0.60
PSMB5	activates	gene	0.60
RPS6KB1	activates	gene	0.60
SMAD	activates	gene	0.60
SQSTM1	activates	gene	0.60
TGFB	activates	gene	0.60
TP53	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
SRC	expressed_in	gene	0.60
XIAP	expressed_in	gene	0.60
MAPK signaling	participates_in	pathway	0.60
SRC	inhibits	gene	0.60
XIAP	inhibits	gene	0.60
XIAP	activates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
ROS	activates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
PDGF	biomarker_for	gene	0.55
EHMT2	interacts_with	gene	0.50
CASPASE3	interacts_with	protein	0.50
BCL-2	interacts_with	protein	0.50
Lymphoma	interacts_with	disease	0.50

Incoming (39)

Source	Relation	Type	Str
APE2	binds	gene	0.80
AKT	activates	gene	0.60
ATG	activates	gene	0.60
CDKN1A	activates	gene	0.60
CDKN2A	activates	gene	0.60
DMSO	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GLB1	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MKI67	activates	gene	0.60
MTOR	activates	gene	0.60
rapamycin	targets	drug	0.60
ERBB2	expressed_in	gene	0.60
ERK	expressed_in	gene	0.60
ERK1	expressed_in	gene	0.60
MAPK	expressed_in	gene	0.60
MEK	expressed_in	gene	0.60
ERBB2	inhibits	gene	0.60
ERK1	inhibits	gene	0.60
EGF	activates	gene	0.60
ERK	activates	gene	0.60
MAPK	activates	gene	0.60
CD31	associated_with	gene	0.60
GSDME	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
EHMT2	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
DCX	activates	gene	0.60
DNA	activates	gene	0.55
DNMT1	activates	gene	0.55
EZH2	activates	gene	0.55
FOXO1	interacts_with	gene	0.50
BCL2	interacts_with	gene	0.50
FOXO1	associated_with	gene	0.50
EHMT2	co_expressed_with	gene	0.50
FOXO1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PCNA

Understanding Entity Pages

Summary

Wiki Pages (20)

Epigenetic Dysregulation in Neurodegeneration

UBE2V1 Gene (UEV-1)

Adult Neurogenesis in Neurodegeneration

POLN Gene — DNA Polymerase Nu

GADD45G as Pathological Sensor: Orchestrating Reactive Gliosis in Neurodegeneration

POLD1

GADD45B Protein

POLD4 Gene

PCNA Protein (Proliferating Cell Nuclear Antigen)

LIG3 Protein — DNA Ligase III

FEN1 — Flap Endonuclease 1

POLD1 Protein

GTF2H2 Protein

ERCC5 (XPG) Gene — Excision Repair Cross-Complementation Group 5

POLD4 Protein

GADD45G — Growth Arrest And DNA Damage Inducible Gamma

GADD45B — Growth Arrest and DNA Damage Inducible Beta

DNA Damage Repair Therapy for Neurodegeneration