concept

PDGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

411Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

3Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	PDGF
Key Genes/Proteins	NFE2L2, AKT, NRF2, PDGFRB
Related Diseases	IPF, Pulmonary Arterial Hypertension, COGNITIVE DECLINE
Related Pathways	oxidative stress response, PI3K/AKT PATHWAY
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PDGF["PDGF"]
    PDGF -->|"activates"| AKT["AKT"]
    PDGF -->|"activates"| PDGFRB["PDGFRB"]
    PDGF -->|"target for"| Infection["Infection"]
    PDGF -->|"target for"| Carcinoma["Carcinoma"]
    PDGF -->|"target for"| Inflammation["Inflammation"]
    PDGF -->|"activates"| Fibrosis["Fibrosis"]
    PDGF -->|"activates"| Als["Als"]
    PDGF -->|"activates"| Senescence["Senescence"]
    PDGF -.protects against.-> T_CELL["T CELL"]
    Nrf2["Nrf2"] -->|"upregulates"| PDGF
    NRF2["NRF2"] -->|"activates"| PDGF
    LMNA["LMNA"] -->|"activates"| PDGF
    AMYLOID["AMYLOID"] -->|"regulates"| PDGF
    APOE["APOE"] -.biomarker for.-> PDGF
    APOE4["APOE4"] -.biomarker for.-> PDGF
    GFAP["GFAP"] -->|"interacts"| PDGF
    AKT -->|"activates"| PDGF
    EGF["EGF"] -->|"causes"| PDGF
    CSF1R["CSF1R"] -->|"contributes to"| PDGF

Outgoing (203)

Target	Relation	Type	Str
AKT	activates	protein	0.90
Vascular Remodelling	involved_in	process	0.90
pulmonary artery smooth muscle cell proliferation	promotes	process	0.90
IPF	inhibits	disease	0.80
oxidative stress response	participates_in	pathway	0.80
Pulmonary Arterial Hypertension	associated_with	disease	0.80
Pulmonary Arterial Hypertension	involved_in	disease	0.75
PDGFRB	activates	gene	0.72
PERICYTE	treats	cell_type	0.70
COGNITIVE DECLINE	exacerbates	phenotype	0.70
COGNITIVE DECLINE	causes	phenotype	0.70
PI3K/AKT PATHWAY	causes	pathway	0.70
PERICYTE	causes	cell_type	0.70
PERICYTE	stabilizes	cell_type	0.70
NEURODEGENERATION	protects_against	phenotype	0.70
PERICYTE	regulates	cell_type	0.70
STROKE	activates	disease	0.70
STROKE	inhibits	disease	0.70
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Infection	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Senescence	activates	disease	0.65
VEGF	increases	gene	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Hepatitis	activates	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Cardiomyopathy	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
pericytes	expressed_in	cell_type	0.65
FIBROBLASTS	activates	cell_type	0.65
T CELL	protects_against	cell_type	0.60
T CELLS	protects_against	cell_type	0.60
PERICYTE	biomarker_for	cell_type	0.60
UBIQUITIN	interacts_with	gene	0.60
STAT3	activates	gene	0.60
TUMOR	expressed_in	disease	0.60
SRC	inhibits	gene	0.60
STING	inhibits	gene	0.60
STING	regulates	gene	0.60
VEGF	associated_with	gene	0.60
PI3K	inhibits	gene	0.60
CYTOKINES	associated_with	gene	0.60
WNT	therapeutic_target	gene	0.60

Incoming (208)

Source	Relation	Type	Str
Nrf2	upregulates	entity	0.95
NFE2L2	upregulates	gene	0.91
NRF2	upregulates	gene	0.90
APOPTOSIS	regulates	phenotype	0.70
APP	regulates	gene	0.70
IGF1	increases	gene	0.65
NRF2	regulates	gene	0.65
MICROGLIA	regulates	cell_type	0.65
LRP1	regulates	gene	0.65
NRF2	activates	protein	0.64
LMNA	activates	gene	0.64
APOE	biomarker_for	gene	0.60
APOE4	biomarker_for	gene	0.60
GFAP	interacts_with	gene	0.60
AKT	activates	gene	0.60
EGF	causes	gene	0.60
CSF1R	contributes_to	gene	0.60
CSF1R	causes	gene	0.60
CSF1R	expressed_in	gene	0.60
JAK	activates	gene	0.60
MTOR	inhibits	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
P16	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60
PDGFRB	therapeutic_target	gene	0.60
GENES	activates	gene	0.60
GENES	expressed_in	gene	0.60
IGF1R	activates	gene	0.60
PDGFRA	interacts_with	gene	0.60
EGF	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
PDGFRB	expressed_in	gene	0.60
KEAP1	activates	gene	0.60
P62	activates	gene	0.60
RNA	activates	gene	0.60
IL-1	activates	gene	0.60
PDGFB	activates	gene	0.60
MERTK	activates	gene	0.60
TREM2	activates	gene	0.60
ENDOTHELIAL	activates	cell_type	0.60
GLIOMA	causes	disease	0.60
JUN	regulates	gene	0.60
MYC	regulates	gene	0.60
AKT	interacts_with	gene	0.60
EGR1	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Pericyte Contractility Reset via Selective PDGFR-β Agonism	0.443	neurodegeneration	Perivascular spaces and glymphatic clear

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726]	Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu	Cell Stem Cell	2025	1
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043]	Kempuraj D, Dourvetakis KD, Cohen J, Val	Front Cell Neurosci	2024	1
The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066]	Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T	Int J Mol Sci	2023	1
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	1
Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333]	Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z	Nature	2021	1
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954]	Montagne A, Nation DA, Sagare AP, Barisa	Nature	2020	1
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990]	Keller A	Annual review of physiology	2026	0
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033]	Levey J, Howe M, Douglas K, Odame E, Raj	bioRxiv : the preprint server	2026	0
Immunological mechanisms and therapeutic approaches in pulmonary fibrosis. [PMID:41951242]	Nell LM, Hendriks RW, Wijsenbeek MS, Cor	Eur Respir Rev	2026	0
Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335]	Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha	Research (Washington, D.C.)	2026	0
Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129]	Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu	Clinical & experimental ophtha	2026	0
Central nervous system pericytes express soluble ST2 in inflammation and injury. [PMID:41857656]	Jansson D, Highet B, Li S, Stevenson TJ,	Molecular brain	2026	0
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235]	Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn	Pathology international	2026	0
The role of endothelial cell-pericyte interactions in vascularization and diseas [PMID:38246244]	Li G, Gao J, Ding P, Gao Y	Journal of advanced research	2025	0
Pericytes in Brain Homeostasis: Developmental Roles and Adult Functions. [PMID:41351407]	Drozd U, Vechkapova S, Lanshakov D	Frontiers in bioscience (Landm	2025	0
Pericyte-derived fibrotic scarring is conserved across diverse central nervous s [PMID:34535655]	Dias DO, Kalkitsas J, Kelahmetoglu Y, Es	Nature communications	2021	0
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfuncti [PMID:30643288]	Nation DA, Sweeney MD, Montagne A, Sagar	Nature medicine	2019	0
Pericytes in Primary Familial Brain Calcification. [PMID:31147881]	Zarb Y, Franzoso FD, Keller A	Advances in experimental medic	2019	0
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. [PMID:29502968]	Dias DO, Kim H, Holl D, Werne Solnestam	Cell	2018	0
Clarifying off-target effects for torcetrapib using network pharmacology and rev [PMID:23228038]	["Fan S", "Geng Q", "Pan Z", "Li X", "Ti	BMC systems biology	2012	0

PDGF

Understanding Entity Pages

Wiki Pages (20)

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Blood-Brain Barrier Dysfunction in Neurodegeneration

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Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

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Tau Pathology Alters Oligodendrocyte Gene Methylation in [Alzheimer's Disease](/diseases/alzheimers-disease)

Astrocyte Senescence Pathway in Neurodegeneration

Neurovascular and Blood-Brain Barrier Dysfunction in Corticobasal Syndrome

Neurovascular Unit Dysfunction Hypothesis in Parkinson's Disease

Brain Pericytes in Neurodegeneration

Senolytic Therapies for Parkinson's Disease