concept

FIBROBLAST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIBROBLAST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1039Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FIBROBLAST
Related Pathways	AUTOPHAGY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Fibroblast Growth Factor Signaling in Neurodegeneration

mechanism · 1987 words

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Pathway Diagram

graph TD
    FIBROBLAST["FIBROBLAST"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| FIBROBLAST
    MICROTUBULES["MICROTUBULES"] -->|"expressed in"| FIBROBLAST
    MAP6["MAP6"] -->|"expressed in"| FIBROBLAST
    TAU["TAU"] -->|"expressed in"| FIBROBLAST
    ROS["ROS"] -->|"expressed in"| FIBROBLAST
    BCL_2["BCL-2"] -->|"expressed in"| FIBROBLAST
    BAD["BAD"] -->|"expressed in"| FIBROBLAST
    HSPG2["HSPG2"] -->|"expressed in"| FIBROBLAST
    IGF1R["IGF1R"] -->|"expressed in"| FIBROBLAST
    DAG1["DAG1"] -->|"expressed in"| FIBROBLAST

Outgoing (56)

Target	Relation	Type	Str
myofibroblast	involved_in	cell_type	0.85
Myofibroblast	associated_with	cell_type	0.85
GLUT4	activates	concept	0.50
GLUCOSE METABOLISM	activates	concept	0.50
Pancreatic Cancer	inhibits	disease	0.50
CELL PROLIFERATION	activates	concept	0.50
Tgf-Β Signaling	activates	pathway	0.50
Hippocampus	expressed_in	brain_region	0.50
Spinal Cord	expressed_in	brain_region	0.50
FIBROBLASTS	interacts_with	concept	0.50
disease	interacts_with	disease	0.50
GENE EXPRESSION	interacts_with	concept	0.50
Rheumatoid Arthritis	interacts_with	disease	0.50
Pain	interacts_with	disease	0.50
FIBROBLASTS	expressed_in	concept	0.50
NEURONS	interacts_with	concept	0.50
Rheumatoid Arthritis	protects_against	disease	0.50
NEURONS	inhibits	concept	0.50
FIBROBLASTS	inhibits	concept	0.50
NEURONS	activates	concept	0.50
NEURONS	associated_with	concept	0.50
Substantia Nigra	expressed_in	brain_region	0.50
Sepsis	associated_with	disease	0.50
Pi3K/Akt	activates	pathway	0.50
Pulmonary Fibrosis	activates	disease	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
disease	activates	disease	0.50
FIBROBLASTS	activates	concept	0.50
MTOR SIGNALING	activates	concept	0.50
Rheumatoid Arthritis	associated_with	disease	0.50
disease	expressed_in	disease	0.50
Spinocerebellar Ataxia	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50
FRONTOTEMPORAL	expressed_in	concept	0.50
HUNTINGTON'S	expressed_in	concept	0.50
STAU1	expressed_in	concept	0.50
Cerebellum	expressed_in	brain_region	0.50
Cortex	expressed_in	brain_region	0.50
Striatum	expressed_in	brain_region	0.50
Reactive Oxygen Species	interacts_with	process	0.50
EXTRACELLULAR MATRIX	interacts_with	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
T CELLS	associated_with	concept	0.50
PERICYTES	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
FIBROBLASTS	associated_with	concept	0.50
B CELLS	associated_with	concept	0.50
PDGF	activates	concept	0.50

Incoming (983)

Source	Relation	Type	Str
CYP46A1	activates	gene	0.60
IL-10	activates	gene	0.60
EXOSOMES	activates	gene	0.60
ROS	activates	gene	0.60
PSEN2	activates	gene	0.60
P21	inhibits	gene	0.60
LRP1	activates	gene	0.60
SOD1	activates	gene	0.60
AXL	activates	gene	0.60
FGF2	activates	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NOTCH	associated_with	gene	0.60
P16	inhibits	gene	0.60
P53	inhibits	gene	0.60
STAT3	activates	gene	0.60
PDGF	activates	gene	0.60
AMPK	activates	gene	0.60
BRSK2	activates	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
MAPK	contributes_to	gene	0.60
BMP2	activates	gene	0.60
EGR1	activates	gene	0.60
NICASTRIN	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
APP	associated_with	gene	0.60
PRESENILIN	contributes_to	gene	0.60
BLM	inhibits	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
RNA	activates	gene	0.60
DEMENTIA	activates	gene	0.60
SPP1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
GRN	activates	gene	0.60
CTSB	activates	gene	0.60
C1QA	activates	gene	0.60
APOE3	activates	gene	0.60
APOE	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
APOE4	activates	gene	0.60
RNA	associated_with	gene	0.60
ARF1	activates	gene	0.60
DNA	interacts_with	gene	0.60
FGF1	interacts_with	gene	0.60
ERK1/2	interacts_with	gene	0.60
FGF2	interacts_with	gene	0.60
FGF	interacts_with	gene	0.60
PDGFRB	activates	gene	0.60
IL-1	inhibits	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1	0.492	neurodegeneration	How do perivascular cells specifically r
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FIBROBLAST in their description or question text

No additional research found